Polymethyl methacrylate (Linnea Safe) causes local inflammatory response after intramuscular implant in BALB/c mice but it is not observed in distant organs

Abstract

The history of muscle biopsy dates back to 1860, when Duchenne first performed a biopsy on a patient with symptoms of myopathy (1) . Since then, the basic and clinical science of muscle and muscle disease has gone through three stages of development: the classical period, the modern stage and the molecular era.

Facial trauma reconstruction with polymethyl methacrylate—A case report

“…Since its registration, it has been rigorously inspected regarding its quality control. Some Brazilian researchers have studied this product in its first version known as Newplastic ® or in its current one marketed as Linnea Safe ® and have reported that this product leads to a local response with predominance of mononuclear cells infiltration that may turn chronic or not depending on the uniformity of the microspheres. Besides Costa et al showed that this product does not migrate to other organs or locations other the ones where the implant occurred.…”