Polymethoxyflavones in black ginger (Kaempferia parviflora) regulate the expression of circadian clock genes

Yoshida, Izumi; Kumagai, Miho; Ide, Masahiro; Horigome, Satoru; Takahashi, Yushi; Mishima, Takashi; Fujita, Kazuhiro; Igarashi, Tomoji

doi:10.1016/j.jff.2020.103900

Cited by 9 publications

(4 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In experimental animals, K. parviflora has been found to increase adaptation to experimental jet lag (6 hour phase progression). Consequently, polymethoxyflavones in K. parviflora can help regulate the circadian clock and reduce circadian distortion (52). It is essential to understand how diet affects epigenetic modifications and the impact of these modifications on cancer development today and in future generations.…”

Section: Discussionmentioning

confidence: 99%

Untitled

2018

TFK

View full text Add to dashboard Cite

The circadian rhythm works as a clock that regulates many physiological processes including metabolism, sleep, neurobehavior, epigenetic and hormone secretion so that disruption of the circadian rhythm causes adverse effects on human health. The mutations in DNA increase the risk of developing cancer (a genetic disease caused by genome damage). Cancer formation is also caused by disruption of the circadian rhythm. Therefore, a cell's ability to properly respond to DNA damage and repair DNA is critical in preventing cancer formation. Prevention of DNA damage is important for the occurrence of cancer. Epidemiological and experimental evidence explain the variation of dietary intake effects in cancer prevalence. Dietary factors may affect the efficiency of DNA repair, their effectiveness on epigenetic mechanisms, as well as circadian rhythm and inhibit cancer formation. The purpose of this review is to reveal the effects of nutrition on circadian rhythm and DNA repair, emphasize the scarcity of existing studies, and pave the way for possible experimental studies. There are very few studies in this field, and the future studies of nutrients that affect circadian rhythm are very valuable in order to find new solutions in cancer treatment. Nutrition may have many effects on the circadian system and DNA repair, and ultimately help reduce the burden of chronic diseases.

show abstract

Section: Discussionmentioning

confidence: 99%

Untitled

2018

TFK

View full text Add to dashboard Cite

show abstract

“…In the same year, it was found that polymethoxyflavones containing 3,5,7,3′,4′-pentamethoxyflavone, 5,7,4′-trimethoxyflavone, and 5,7-dimethoxyflavonein black ginger ( Kaempferia parviflora ) were regulative, reflected in the expression of CCGs including Bmal1, Cry1, and Per2. 99 Moreover, the extract also ameliorated some negative effects induced by jetlag in mouse models. Qi et al revealed that dietary tea polyphenols composed of gallic acid, epigallocatechin, epigallocatechin-3-gallate, and epicatechin-3-gallate could ameliorate memory impairment and metabolic disorder, including insulin resistance and glucose/lipid metabolism dysfunction induced by constant darkness in a mouse model.…”

Section: Intervention or Supplementation Of Phytochemicals Potentiall...mentioning

confidence: 93%

“…The extract was rich in kaempferol and quercetin derivatives, and the major outcomes of the supplementation were reflected in the body weight, the decrement of the F/B value, gut microbial diurnal oscillation, and the corresponding functionality of gut microbes. In the same year, it was found that polymethoxyflavones containing 3,5,7,3′,4′-pentamethoxyflavone, 5,7,4′-trimethoxyflavone, and 5,7-dimethoxyflavonein black ginger ( Kaempferia parviflora ) were regulative, reflected in the expression of CCGs including Bmal1, Cry1, and Per2 . Moreover, the extract also ameliorated some negative effects induced by jetlag in mouse models.…”

Section: Intervention or Supplementation Of Phytochemicals Potentiall...mentioning

confidence: 99%

Food-Borne Polycyclic Aromatic Hydrocarbons and Circadian Disruption

Koh,

Pan

2024

ACS Omega

View full text Add to dashboard Cite

Circadian disruption has been found to increase the risk of metabolic diseases, brain disorders, and cancer. The aryl hydrocarbon receptor (AhR), responsible for xenobiotic metabolism, is known to be activated by certain environmental stimuli, including polycyclic aromatic hydrocarbons (PAHs). Exposure to these stimuli may lead to diseases related to circadian disruption, with AhR activation suggested as a leading cause. Both the aryl hydrocarbon receptor nuclear translocator (ARNT) and aryl hydrocarbon receptor nuclear translocator-like (BMAL1) are class II basic helix−loop−helix/Per-ARNT-SIM (bHLH-PAS) proteins. These proteins form heterodimers with stimulated class I bHLH-PAS proteins, including circadian locomotor output cycles kaput (CLOCK) and AhR. Due to their sequential similarity, the overactivation of AhR by toxicants, such as PAHs, may lead to the formation of heterodimers with BMAL1, potentially causing circadian disruption. Dysregulation of BMAL1 can affect a wide range of metabolic genes, emphasizing its crucial roles. However, this issue has not been adequately addressed. Previous studies have reported that the inhibitory effects of phytochemicals on AhR activation can ameliorate diseases induced by environmental toxicants. Additionally, some phytochemicals have shown preventive effects on circadian misalignment. Therefore, this Review aims to explore potential strategies to prevent circadian disruption induced by food-borne toxicants, such as benzo[a]pyrene; to generate new ideas for future studies; and to highlight the importance of investigating these preventive strategies.

show abstract

“…Besides Citrus species, a few other plants also contain PMFs. For example, black ginger (Kaempferia parviflora) is rich in PMFs, and 3,5,7,3',4'-pentamethoxyflavone, 5,7,4'-trimethoxyflavone, and 5,7-dimethoxyflavone were identified as the main PMFs in it [2] . In addition, Qinghao (Artemisia annua L.), a first-line antimalarial drug, also contained PMFs, such as artemetin, in its leaves and inflorescences [3,4] .…”

Section: Main Natural Sources Of Pmfsmentioning

confidence: 99%

Natural sources, refined extraction, biosynthesis, metabolism, and bioactivities of dietary polymethoxyflavones (PMFs)

Gan¹,

Liu²,

Li³

et al. 2024

Food Science and Human Wellness

View full text Add to dashboard Cite

Polymethoxyflavones (PMFs) are a type of uncommon dietary flavonoids, characterized by more than one methoxy group, which exist in limited plant species, like Citrus species and Kaempferia parviflora. In addition, different PMFs, such as nobiletin, sinensetin, tangeretin, and casticin, have been isolated from these natural sources. PMFs have received increasing attention due to their multiple bioactivities, such as antioxidant, anti-inflammatory, anti-cancer, metabolic regulatory, immunoregulatory, neuroprotective, and skin protective effects. These bioactivities of PMFs should be associated with the regulation of critical molecular targets and the interaction with gut microbiota. In order to provide a comprehensive and updated review of PMFs, their natural sources, refined extraction, biosynthesis, metabolism, and bioactivities are summarised and discussed, with the emphasis on the molecular mechanisms of PMFs on regulating different chronic diseases. Overall, PMFs may be promising flavonoids to the forefront of nutraceuticals for the prevention and/or treatment of certain human chronic diseases.

show abstract

Polymethoxyflavones in black ginger (Kaempferia parviflora) regulate the expression of circadian clock genes

Cited by 9 publications

References 53 publications

Untitled

Untitled

Food-Borne Polycyclic Aromatic Hydrocarbons and Circadian Disruption

Natural sources, refined extraction, biosynthesis, metabolism, and bioactivities of dietary polymethoxyflavones (PMFs)

Contact Info

Product

Resources

About