Polymethine Dyes as Probes for Detecting the SARS-COV-2 Coronavirus: In silico Molecular Docking Study

Пронкин, П. Г.; Татиколов, А. С.

doi:10.1134/s1990793121010267

Cited by 7 publications

(1 citation statement)

References 24 publications

(18 reference statements)

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“…These are often similar between various viral subtypes and also for different viruses. An attachment of viruses to their respective host cells precedes the actual infection and is usually mediated by virus–receptor interactions, cellular glycosaminoglycans (GAGs), or sialic acid containing carbohydrates, e.g., glycans [ 78 , 81 , 82 ]. A current platform technology that has been found to be suitable for various viruses and some VLPs is based on glycosaminoglycans (GAGs), such as heparin and heparan sulfate, respectively [ 83 , 84 , 85 ].…”

Section: Development Of Affinity Purifications For Viruses and Vlps A...mentioning

confidence: 99%

Affinity and Pseudo-Affinity Membrane Chromatography for Viral Vector and Vaccine Purifications: A Review

Lothert,

Wolff

2023

Membranes

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Several chromatographic approaches have been established over the last decades for the production of pharmaceutically relevant viruses. Due to the large size of these products compared to other biopharmaceuticals, e.g., proteins, convective flow media have proven to be superior to bead-based resins in terms of process productivity and column capacity. One representative of such convective flow materials is membranes, which can be modified to suit the particular operating principle and are also suitable for economical single-use applications. Among the different membrane variants, affinity surfaces allow for the most selective separation of the target molecule from other components in the feed solution, especially from host cell-derived DNA and proteins. A successful membrane affinity chromatography, however, requires the identification and implementation of ligands, which can be applied economically while at the same time being stable during the process and non-toxic in the case of any leaching. This review summarizes the current evaluation of membrane-based affinity purifications for viruses and virus-like particles, including traditional resin and monolith approaches and the advantages of membrane applications. An overview of potential affinity ligands is given, as well as considerations of suitable affinity platform technologies, e.g., for different virus serotypes, including a description of processes using pseudo-affinity matrices, such as sulfated cellulose membrane adsorbers.

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Section: Development Of Affinity Purifications For Viruses and Vlps A...mentioning

confidence: 99%

Affinity and Pseudo-Affinity Membrane Chromatography for Viral Vector and Vaccine Purifications: A Review

Lothert,

Wolff

2023

Membranes

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Correction of the Mechanism of Photolysis of Aminoazobenzole According to Kinetic Picosecond Spectroscopy

Mikheev

Ломакин

2022

Russ. J. Phys. Chem. B

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Molecular Docking of Cyanine and Squarylium Dyes with NSP15 Endoribonuclease of the SARS-CoV-2 Coronavirus

Пронкин

Татиколов

2022

Russ. J. Phys. Chem. B

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Polymethine Dyes as Probes for Detecting the SARS-COV-2 Coronavirus: In silico Molecular Docking Study

Cited by 7 publications

References 24 publications

Affinity and Pseudo-Affinity Membrane Chromatography for Viral Vector and Vaccine Purifications: A Review

Affinity and Pseudo-Affinity Membrane Chromatography for Viral Vector and Vaccine Purifications: A Review

Correction of the Mechanism of Photolysis of Aminoazobenzole According to Kinetic Picosecond Spectroscopy

Molecular Docking of Cyanine and Squarylium Dyes with NSP15 Endoribonuclease of the SARS-CoV-2 Coronavirus

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