Polymethacrylate microparticles covalently functionalized with an ionic liquid for solid-phase extraction of fluoroquinolone antibiotics

Abstract

Microparticles were synthesized by suspension copolymerization of the synthetic ionic liquid (IL) 1-allyl-3-methylimidazolium bromide with ethylene glycol dimethacrylate. The particles have a regular spherical shape and an average diameter of 65±24 μm. Their affinity for the fluoroquinolone antibiotics ofloxacin (OFL), lomefloxacin (LOM) and ciprofloxacin (CIP) is much higher than that of the blank polymer (not containing an IL), of polymers using methacrylic acid as functional monomer, of hydrophilic-lipophilic balanced sorbents, and of C 18 sorbents. The microparticles were applied to the solid-phase extraction and rapid preconcentration of the fluoroquinolones from urine which then were quantified by HPLC. The calibration plot covers the 0.05 to 20 μg mL −1 concentration range, and the average recoveries at three spiking levels range from 93.6 to 103.7 %, with RSD of ≤5.7 %. The method was successfully applied to the determination of fluoroquinolones in spiked urine.

Surface-imprinted magnetic nanoparticles for the selective enrichment and fast separation of fluoroquinolones in human serum

“…Given the complexity of sample matrices and low concentration of FQs in biological samples, suitable sample preparation techniques should be used for sample clean‐up and enrichment . However, some adsorbents used in the sample preparation steps are of poor selectivity and easily interfered by sample impurities.…”

A Cross-Linker-Based Poly(Ionic Liquid) for Sensitive Electrochemical Detection of 4-Nonylphenol

“…Therefore, PILs are smart materials having the advantages of ILs (enhanced ionic conductivity and high electrochemical stability) combined with excellent processability and good mechanical performances and resulting from the polymeric structure [10,11]. Owing to such unique combination of properties, PILs find applications [12] in diverse fields such as electrochemical supercapacitors [13], catalyst [14], gas adsorption [15], extraction [16,17,18,19], capillary electrochromatography [20], electrochemical sensors [21,22] and fluorescent determination [23]. In recent years, PIL-based materials prepared with IL monomer as modifiers for electrochemical sensors have been found to exhibit high sensitivity for analytes [24,25,26,27].…”