Polymersomes for Targeted Drug and Gene Delivery Systems

Silva, Rita Y. P. da; Silva, Larissa C. G. da; Ricardo, Maria F. C. S.; Lima, Ádley Antonini Neves de

doi:10.1007/978-3-031-12658-1_14

Cited by 2 publications

(2 citation statements)

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“…The thicker membrane contributes to a less permeable structure with relatively low lateral mobility, enabling the polymersomes to encapsulate substantial amounts of drugs with minimal leakage. Additionally, polymersomes offer advantages such as biocompatibility, a low aggregation rate, longer blood circulation time, immune evasion, and improved uptake in targeted cells. − In terms of drug release, polymersomes can release drugs in response to stimuli (e.g., pH, temperature, etc.) and control drug release by forming pores .…”

Section: Introductionmentioning

confidence: 99%

Review of Shape Transformation Pathways of Polymersomes: Implications for Nanomotor, Biomedicine, and Artificial Cell Mimics

Zhang,

van Hest,

Men

2024

ACS Appl. Nano Mater.

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Polymersomes have been studied for many years since their discovery, and have consistently been an appealing and widely explored research domain. Their inherent benefits, encompassing stability, versatility, load-carrying capacity, and deformability, endow them with many opportunities to be used in numerous fields of biomedicine, nanocarriers, diagnostics and therapeutics. Nevertheless, shape transformation pathways have not been comprehensively summarized or received adequate scholarly attention. Herein, we summarize typical mechanisms underlying polymersome self-assembly with a particular focus on the shape transformation pathways associated with commonly employed self-assembling methods. Moreover, we provide a succinct overview of the proposed applications involving shape transformation applications, and enumerate the most recent findings in this domain.

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Section: Introductionmentioning

confidence: 99%

Review of Shape Transformation Pathways of Polymersomes: Implications for Nanomotor, Biomedicine, and Artificial Cell Mimics

Zhang,

van Hest,

Men

2024

ACS Appl. Nano Mater.

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“…[9][10][11] (3) More functional effects can be achieved by modifying the surface of polymersomes. 12,13 Biodegradable materials such as polylactide acid (PLA), poly ε-caprolactone (PCL), or non-biodegradable materials such as polybutadiene (PBD) can be used as the hydrophobic blocks. [14][15][16][17] The hydrophilic blocks mainly contain polyethylene glycol (PEG), polyacrylic acid (PAA), poly glycolic acid (PGA) and so on.…”

Section: Introductionmentioning

confidence: 99%

Co-Delivery of paclitaxel and doxorubicin in folate-Targeted pluronic/ploy (D,L-lactide-b-glycolide) polymersomes

Wen

et al. 2023

J Biomater Appl

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Drugs with different solubility can be selectively embedded into polymersomes with the hydrophilic core and hydrophobic bilayer. Novel folate-targeted Pluronic/poly (D,L-lactide- b-glycolide) polymersomes were constructed and used for the co-delivery of paclitaxel (PTX) and doxorubicin (DOX) to improve their inhibitory effect over cancer cells. The particle size of blank polymersomes was mainly distributed below 125 nm. The release of PTX and DOX from polymersomes showed an initial burst release followed by a sustained and slow release. The in vitro cytotoxicity data showed that the targeted co-loaded polymersomes (PTX&DOX FA-Ps) exhibited better inhibitory effect than single-loaded polymersomes and free drugs did. Furthermore, PTX&DOX FA-Ps showed the synergistic therapeutic effect over OVCAR-3 cancer cells. The cellular uptake results also showed that folate modified polymersomes had excellent targeting performance. Therefore, the folate-targeted Pluronic/poly (D,L-lactide- b-glycolide) polymersomes have potential application value as novel drug carriers to co-deliver PTX and DOX.

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Polymersomes for Targeted Drug and Gene Delivery Systems

Cited by 2 publications

References 121 publications

Review of Shape Transformation Pathways of Polymersomes: Implications for Nanomotor, Biomedicine, and Artificial Cell Mimics

Review of Shape Transformation Pathways of Polymersomes: Implications for Nanomotor, Biomedicine, and Artificial Cell Mimics

Co-Delivery of paclitaxel and doxorubicin in folate-Targeted pluronic/ploy (D,L-lactide-b-glycolide) polymersomes

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