Polymersomes: Breaking the Glass Ceiling?

Chidanguro, Tamuka; Ghimire, Elina; Liu, Cheyenne H.; Simon, Yoan C.

doi:10.1002/smll.201802734

Cited by 22 publications

(21 citation statements)

References 203 publications

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“…This method includes a hydrophilic micro-initiator or macro-chain transfer agent that polymerizes the hydrophobic block and appends the water-soluble segment. Morphologies progress from high to lower curvature structures, such as polymersomes, as the block length increases [ 15 , 152 ].…”

Section: Polymersomes As a Platform For Anticancer Therapeutic Deliverymentioning

confidence: 99%

Light-Triggered Polymersome-Based Anticancer Therapeutics Delivery

et al. 2022

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Polymersomes are biomimetic cell membrane-like model structures that are self-assembled stepwise from amphiphilic copolymers. These polymeric (nano)carriers have gained the scientific community’s attention due to their biocompatibility, versatility, and higher stability than liposomes. Their tunable properties, such as composition, size, shape, and surface functional groups, extend encapsulation possibilities to either hydrophilic or hydrophobic cargoes (or both) and their site-specific delivery. Besides, polymersomes can disassemble in response to different stimuli, including light, for controlling the “on-demand” release of cargo that may also respond to light as photosensitizers and plasmonic nanostructures. Thus, polymersomes can be spatiotemporally stimulated by light of a wide wavelength range, whose exogenous response may activate light-stimulable moieties, enhance the drug efficacy, decrease side effects, and, thus, be broadly employed in photoinduced therapy. This review describes current light-responsive polymersomes evaluated for anticancer therapy. It includes light-activable moieties’ features and polymersomes’ composition and release behavior, focusing on recent advances and applications in cancer therapy, current trends, and photosensitive polymersomes’ perspectives.

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Section: Polymersomes As a Platform For Anticancer Therapeutic Deliverymentioning

confidence: 99%

Light-Triggered Polymersome-Based Anticancer Therapeutics Delivery

et al. 2022

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“…Amphiphilic polymers, whether diblock (hydrophilic and hydrophobic blocks), triblock (hydrophobic block between two hydrophilic blocks), or graft (hydrophilic side chains on a hydrophobic backbone), can assemble into spherical micelles, cylindrical micelles, or polymersomes ( i.e. , spherical vesicles). − The morphology is, to a first approximation, determined by the packing parameter of the polymer chains, which considers the volume of the hydrophobic block, the area occupied by the hydrophilic block, and the length of the chain. , Polymersomes, which are synthetic polymer analogues of liposomes, span dimensions from tens of nanometers to micrometers and have membranes that are ca. 5–50 nm thick. , Compared with liposomes, polymersomes have lower permeability, less lateral fluidity, more structural and colloidal stability, and more chemical versatility .…”

Section: Catalog Of Materialsmentioning

confidence: 99%

Photoluminescent Nanoparticles for Chemical and Biological Analysis and Imaging

et al. 2021

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Research related to the development and application of luminescent nanoparticles (LNPs) for chemical and biological analysis and imaging is flourishing. Novel materials and new applications continue to be reported after two decades of research. This review provides a comprehensive and heuristic overview of this field. It is targeted to both newcomers and experts who are interested in a critical assessment of LNP materials, their properties, strengths and weaknesses, and prospective applications. Numerous LNP materials are cataloged by fundamental descriptions of their chemical identities and physical morphology, quantitative photoluminescence (PL) properties, PL mechanisms, and surface chemistry. These materials include various semiconductor quantum dots, carbon nanotubes, graphene derivatives, carbon dots, nanodiamonds, luminescent metal nanoclusters, lanthanidedoped upconversion nanoparticles and downshifting nanoparticles, triplet−triplet annihilation nanoparticles, persistent-luminescence nanoparticles, conjugated polymer nanoparticles and semiconducting polymer dots, multi-nanoparticle assemblies, and doped and labeled nanoparticles, including but not limited to those based on polymers and silica. As an exercise in the critical assessment of LNP properties, these materials are ranked by several application-related functional criteria. Additional sections highlight recent examples of advances in chemical and biological analysis, point-of-care diagnostics, and cellular, tissue, and in vivo imaging and theranostics. These examples are drawn from the recent literature and organized by both LNP material and the particular properties that are leveraged to an advantage. Finally, a perspective on what comes next for the field is offered.

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“…19 Over the last two decades, a number of reviews have shed more light on polymersome formation, and the influence of factors such as solvent or polymer dispersity on polymersome formation. [20][21][22][23]…”

Section: Self-assembly and Polymersome Formationmentioning

confidence: 99%

Bent out of shape: towards non‐spherical polymersome morphologies

Chidanguro

Simon

2021

Polymer International

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Polymersomes have gained a lot of attention in recent years. Their compartmentalized, hollow nature, stability and ability to transport both hydrophilic and hydrophobic cargo has made them attractive for increasingly complex applications in various fields of biomedicine, catalysis and diagnostics. Progress in these fields would therefore benefit from improvements in polymersome functionality. Recently, morphological control of polymersomes, namely the fabrication of various non-spherical morphologies, has emerged as a means to enhance the usefulness of the polymersomes. In the present review, we highlight the most topical trends in this field and how these developments and the newly acquired knowledge about their nature can be leveraged towards applications.

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Polymersomes: Breaking the Glass Ceiling?

Cited by 22 publications

References 203 publications

Light-Triggered Polymersome-Based Anticancer Therapeutics Delivery

Light-Triggered Polymersome-Based Anticancer Therapeutics Delivery

Photoluminescent Nanoparticles for Chemical and Biological Analysis and Imaging

Bent out of shape: towards non‐spherical polymersome morphologies

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