Polymers with antiviral properties: A brief review

Zmonarski, Sławomir; Stojanowski, Jakub; Zmonarska, Joanna

doi:10.17219/pim/131643

Cited by 5 publications

(4 citation statements)

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“…The strategies using polymeric macromolecules as antivirals have been widely studied. Initially, natural polymers were used as backbones (e.g., polysaccharides), but soon the research expanded to also utilize synthetic polymers [18][19][20][21]. High efficacy, ease of modification and low toxicity compared to small molecule drugs make them attractive candidates for antiviral drugs.…”

Section: Introductionmentioning

confidence: 99%

Self-Organized Nanoparticles of Random and Block Copolymers of Sodium 2-(Acrylamido)-2-methyl-1-propanesulfonate and Sodium 11-(Acrylamido)undecanoate as Safe and Effective Zika Virus Inhibitors

et al. 2022

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A series of anionic homopolymers, poly(sodium 2-(acrylamido)-2-methyl-1-propanesulfonate) (PAMPS) and amphiphilic copolymers of AMPS and sodium 11-(acrylamido)undecanoate (AaU), both block (PAMPS75-b-PAaUn), and random (P(AMPSm-co-AaUn)), were synthesized and their antiviral activity against Zika virus (ZIKV) was evaluated. Interestingly, while the homopolymers showed limited antiviral activity, the copolymers are very efficient antivirals. This observation was explained considering that under the conditions relevant to the biological experiments (pH 7.4 PBS buffer) the macromolecules of these copolymers exist as negatively charged (zeta potential about −25 mV) nanoparticles (4–12 nm) due to their self-organization. They inhibit the ZIKV replication cycle by binding to the cell surface and thereby blocking virus attachment to host cells. Considering good solubility in aqueous media, low toxicity, and high selectivity index (SI) of the PAMPS-b-PAaU copolymers, they can be considered promising agents against ZIKV infections.

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Section: Introductionmentioning

confidence: 99%

Self-Organized Nanoparticles of Random and Block Copolymers of Sodium 2-(Acrylamido)-2-methyl-1-propanesulfonate and Sodium 11-(Acrylamido)undecanoate as Safe and Effective Zika Virus Inhibitors

et al. 2022

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“… 752 Fullerenes Antioxidant properties; stable structure; surface modification to obtain multiple properties Relatively low load capacity; low solubility in water Fullerene derivatives inhibit HIV by complexing with HIV protease. 753 C60-β-cyclodextrin conjugate improves nuclear transport of doxorubicin 754 Polymeric NPs Natural hydrophilic polymers and synthetic hydrophobic polymers Good drug loading capacity and controlled release capabilities; easy synthesis and regulation Long-term toxicity from body accumulation; potentially toxic degradation products； complex preparation and functionalization Porous PLA and PLGA NPs for pulmonary delivery of HBV vaccine 105 , 755 (PEG-b-PLA) NPs improve protein affinity for delivered drugs 756 Protein NPs VLP High structural stability and resistance to degradation; immunocompatibility; biomimetic properties Inefficient protein delivery in vivo; insufficient immunogenicity, requiring adjuvants and multiple injections for vaccination; complex preparation process Novel virus-like particle vaccine encoding the circumsporozoite protein of plasmodium falciparum is Immunogenic. 757 Engineered VLPs for efficient delivery of therapeutic proteins.…”

Section: Advanced Nanotechnologiesmentioning

confidence: 99%

Nanotechnology’s frontier in combatting infectious and inflammatory diseases: prevention and treatment

Huang,

Guo,

et al. 2024

Sig Transduct Target Ther

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Inflammation-associated diseases encompass a range of infectious diseases and non-infectious inflammatory diseases, which continuously pose one of the most serious threats to human health, attributed to factors such as the emergence of new pathogens, increasing drug resistance, changes in living environments and lifestyles, and the aging population. Despite rapid advancements in mechanistic research and drug development for these diseases, current treatments often have limited efficacy and notable side effects, necessitating the development of more effective and targeted anti-inflammatory therapies. In recent years, the rapid development of nanotechnology has provided crucial technological support for the prevention, treatment, and detection of inflammation-associated diseases. Various types of nanoparticles (NPs) play significant roles, serving as vaccine vehicles to enhance immunogenicity and as drug carriers to improve targeting and bioavailability. NPs can also directly combat pathogens and inflammation. In addition, nanotechnology has facilitated the development of biosensors for pathogen detection and imaging techniques for inflammatory diseases. This review categorizes and characterizes different types of NPs, summarizes their applications in the prevention, treatment, and detection of infectious and inflammatory diseases. It also discusses the challenges associated with clinical translation in this field and explores the latest developments and prospects. In conclusion, nanotechnology opens up new possibilities for the comprehensive management of infectious and inflammatory diseases.

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“… 43 Recently, these materials have been incorporated into polymer filtration media to give N95 respirators antiviral properties. 44 , 45 Copper sulfide (CuS) has been impregnated in nylon at 4.4% and 17.6% (w/w) in the outer and inner layers, respectively, in a three-layer respirator. The respirator showed nearly complete virus deactivation after 1 h as observed by cytopathy, fluorescence, and viral copy number.…”

Section: Antiviral Filtration Mediamentioning

confidence: 99%

Recent developments in filtration media and respirator technology in response to COVID-19

et al. 2021

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The COVID-19 pandemic triggered a surge in demand for N95 or equivalent respirators that the global supply chain was unable to satisfy. This shortage in critical equipment has inspired research that addresses the immediate problems and has accelerated the development of the next-generation filtration media and respirators. This article provides a brief review of the most recent work with regard to face respirators and filtration media. We discuss filtration efficiency of the widely utilized cloth masks. Next, the sterilization of and reuse of existing N95 respirators to extend the existing stockpile is discussed. To expand near-term supplies, optimization of current manufacturing methods, such as melt-blown processes and electrospinning, has been explored. Future manufacturing methods have been investigated to address long-term supply shortages. Novel materials with antiviral and sterilizable properties with the ability for multiple reuses have been developed and will contribute to the development of the next generation of longer lasting multi-use N95 respirators. Finally, additively manufactured respirators are reviewed, which enable a rapidly deployable source of reusable respirators that can use any filtration fabric. Graphic abstract

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Polymers with antiviral properties: A brief review

Cited by 5 publications

References 0 publications

Self-Organized Nanoparticles of Random and Block Copolymers of Sodium 2-(Acrylamido)-2-methyl-1-propanesulfonate and Sodium 11-(Acrylamido)undecanoate as Safe and Effective Zika Virus Inhibitors

Self-Organized Nanoparticles of Random and Block Copolymers of Sodium 2-(Acrylamido)-2-methyl-1-propanesulfonate and Sodium 11-(Acrylamido)undecanoate as Safe and Effective Zika Virus Inhibitors

Nanotechnology’s frontier in combatting infectious and inflammatory diseases: prevention and treatment

Recent developments in filtration media and respirator technology in response to COVID-19

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