Polymers of malic acid and 3-alkylmalic acid as synthetic PHAs in the design of biocompatible hydrolyzable devices

Cammas, Sandrine; Bear, Marie Maud; Moine, Laurence; Escalup, Raphaële; Ponchel, Gilles; Kataoka, Kazunori; Guérin, Philippe

doi:10.1016/s0141-8130(99)00042-2

Cited by 76 publications

(67 citation statements)

References 22 publications

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“…and randomly distributed on the backbone allowed modulating solubility and degradation rate [69][70][71]. So, associating polymers, hydrogels, degradation micelles, macromolecular prodrugs, graft polyesters, and bioactive compounds has been synthesized and characterized [72][73][74][75]. Only during the synthesis of the various homopolymers and copolymers, it was difficult to obtain controlled high molecular weights.…”

Section: Historymentioning

confidence: 99%

“…However, these ionic and non-charged polyesters will be used on one hand for their hydrophilic properties and on the other hand for allowing chemical modifications and reacting with bioactive or targeting molecules [73,74,94]. Moreover, −OH functions were often used for their opsonization phenomenon and their excellent blood compatibility and resistance to thrombus formation [54] and carboxylic groups for their favor cell attachment and proliferation.…”

Section: Interests and Application Of Pdmmlasmentioning

confidence: 99%

“…As mentioned above, these ionic and non-charged groups (carboxylic acid and alcohol, resp.) are used on one hand for their hydrophilic properties and on the other hand for the possibility to react with bioactive or targeting molecules [73,74,94]. The hexylic group is used for its hydrophobic properties, which gives access to a wide variety of amphiphilic copolymers.…”

Section: Scheme 5 Synthetic Route Of Amorphous Pdmmla Derivativesmentioning

confidence: 99%

“…PMLA has many interesting properties, in addition to its functionalisable properties, such as non-toxicity in vitro and in vivo, non-immunogenicity, biodegradability, stability in the bloodstream, and cell affinity [39][40][41][42][43]. However, its application is limited because of the synthesis conditions (time and cost) and transfer reactions during its chemical synthesis and/or modification [18,[44][45][46][47][48][49][50][51][52][53].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

New promising biodegradable polyesters derived from poly((R,S)-3,3-dimethylmalic acid) for cardiovascular applications

Belibel¹,

Barbaud²

2017

Biodegradable Polymers: Recent Developments and New Perspectives

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Section: Historymentioning

confidence: 99%

Section: Interests and Application Of Pdmmlasmentioning

confidence: 99%

Section: Scheme 5 Synthetic Route Of Amorphous Pdmmla Derivativesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

New promising biodegradable polyesters derived from poly((R,S)-3,3-dimethylmalic acid) for cardiovascular applications

Belibel¹,

Barbaud²

2017

Biodegradable Polymers: Recent Developments and New Perspectives

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“…The ideal biomaterial for wound dressing must be possessing properties such as biocompatibility, gaseous exchange, flexibility, biodegradability, safeguard to prevent the bacterial infection and remove excess exudates [4,5]. Some of the commonly used polymers in medicine namely silicones, have been suspected to cause cancer and thus must be replaced by some biocompatible polymers [6]. Among various available biogenic polymers, polyhydroxyalkanoate (PHA) is a biopolymer produced by various bacterial cells under imbalanced growth condition [7].…”

Section: Introductionmentioning

confidence: 99%

Fabrication and Characterization of Electrospun PHA/Graphene Silver Nano-Composite Scaffold for Antibacterial Application

Mukheem¹,

Muthoosamy²,

Manickam³

et al. 2018

Preprint

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Many wounds are unresponsive to current available treatment techniques and therefore there is an immense need to explore suitable materials including biomaterials, which are being considered as the crucial factor to accelerate the healing cascade. In this study, we fabricated polyhydroxyalkanoate based antibacterial mats via electrospun technique. One-pot green synthesized graphene decorated silver nanoparticles (GAg) were incorporated into the fibres of poly-3 hydroxybutarate-co-12 mol% hydroxyhexanoate (P3HB-co-12mol% HHx), a co-polymer of polyhydroxyalkanoate (PHA) family which is highly biocompatible, biodegradable and flexible in nature. The synthesised PHA/GAg biomaterial was characterized by field emission scanning electron microscopy (FESEM), elemental mapping, thermogravimetric analysis (TGA), UV-visible spectroscopy (UV-vis) and Fourier transform infrared spectroscopy (FTIR). In-vitro antibacterial analysis were performed to investigate the efficacy of PHA/GAg against gram positive Staphylococcus aureus (S.aureus) strain 12600 ATCC and gram negative Escherichia coli (E.coli) strain 8739 ATCC. The results indicated that the PHA/GAg demonstrated significant reduction of Staphylococcus aureus (S.aureus strain 12600 ATCC) and Escherichia coli (E.coli strain 8739 ATCC) as compared to bare PHA or PHA-rGO in 2 hours of time. The P value (P< 0.05) was obtained by using 2 sample T-test distribution.

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Influence of structural parameters on the ring-opening polymerization of new alkyl malolactonate monomers and on the biocompatibility of polymers therefrom

Bizzarri

Chiellini

Ober

et al. 2002

Macromol. Chem. Phys.

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The geometry of several alkyl malolactonate monomers was investigated by NMR and semiempirical computational methods. The results obtained by both techniques indicated that the geometry of the malolactone ring is almost independent of the nature of the side ester group. 13C NMR analysis of the polymer backbone stereochemistry ruled out the occurrence of stereoelective processes in the polymerization of racemic monomers. The observed influence of the bulkiness of the alkyl group on the polymerization rate was therefore attributed to steric interactions between this group and the polymer growing‐end. Preliminary in‐vitro investigation of cell adhesion and proliferation on the surface of homopolymers and copolymers of the investigated alkyl malolactonates suggested a possible correlation between polymer hydrophobicity and biocompatibility.

show abstract

Polymers of malic acid and 3-alkylmalic acid as synthetic PHAs in the design of biocompatible hydrolyzable devices

Cited by 76 publications

References 22 publications

New promising biodegradable polyesters derived from poly((R,S)-3,3-dimethylmalic acid) for cardiovascular applications

New promising biodegradable polyesters derived from poly((R,S)-3,3-dimethylmalic acid) for cardiovascular applications

Fabrication and Characterization of Electrospun PHA/Graphene Silver Nano-Composite Scaffold for Antibacterial Application

Influence of structural parameters on the ring-opening polymerization of new alkyl malolactonate monomers and on the biocompatibility of polymers therefrom

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