Polymers of Biological Origin

Silva, S.S.; Oliveira, Joaquim Miguel Antunes de; Sá-Lima, Helena; Sousa, Rui A.; Mano, J. F.; Reis, R. L.

doi:10.1016/b978-0-08-055294-1.00069-6

Cited by 5 publications

(7 citation statements)

References 236 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Besides, polymer cellulose origin from plants, different acetic acid‐ and other bacteria synthesize nano‐sized polymer cellulose fibers called bacterial cellulose (BC). This hydrogel material has crystalline nanofibrillar structure, which enables large surface area, versatility, moldability, good biocompatibility and biodegradability, high water‐holding ability, cost effect production, and high mechanical strength in the wet state 12 . Nanomaterials impregnated into polymers might be capable of efficient wound healing or can serve as carriers for delivering therapeutic agents.…”

Section: Introductionmentioning

confidence: 99%

“…This hydrogel material has crystalline nanofibrillar structure, which enables large surface area, versatility, moldability, good biocompatibility and biodegradability, high waterholding ability, cost effect production, and high mechanical strength in the wet state. 12 Nanomaterials impregnated into polymers might be capable of efficient wound healing or can serve as carriers for delivering therapeutic agents. Various fillers, such as antibiotics or nanoparticles (NPs), metal or metallic oxide NPs (silver, gold, copper or ZnO) can be impregnated into polymer matrix.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Antibacterial composite hydrogels of graphene quantum dots and bacterial cellulose accelerate wound healing

et al. 2022

View full text Add to dashboard Cite

The increased antibiotic resistance of pathogenic bacteria requires intense research of new wound healing agents. Novel wound dressings should be designed to provide wound disinfection, good moisture, and fast epithelization. In this study, bacterial cellulose (BC) was impregnated with graphene quantum dots (GQDs) for potential use in wound healing treatment. The BC was successfully loaded with approximately 11.7 wt% of GQDs. The actual release of GQDs from new designed composite hydrogels were 13%. Novel GQDs‐BC hydrogel composites are biocompatible and showed significant inhibition towards Staphylococcus aureus and Streptococcus agalactiae and bactericidal effect towards Methicillin‐resistant Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. The in vitro healing analysis showed significant migration of human fibroblasts after the GQDs‐BC hydrogels application. Furthermore, after 72 h exposure to GQDs‐BC, endothelial nitric oxide synthase, vascular endothelial growth factor A, matrix metallopeptidase 9, and Vimentin gene expression in fibroblast were significantly upregulated promoting angiogenesis. GQDs‐BC hydrogel composites showed very good wound fluid absorption and water retention, which satisfies good dressing properties. All obtained results propose new designed GQDs‐BC hydrogels as potential wound dressings.

show abstract

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

Antibacterial composite hydrogels of graphene quantum dots and bacterial cellulose accelerate wound healing

et al. 2022

View full text Add to dashboard Cite

show abstract

“…1b) leading to antiparallel βpleated sheet formation in the fibers [11,12]. SF possess good biocompatibility, toughness, elasticity and biodegradability which makes it a good biomaterial for tissue engineering and regenerative medicine [13]. PLA/Silk fibroin composite fiber membrane provides a good environment for cell growth and proliferation of cells [10,14].…”

Section: Introductionmentioning

confidence: 99%

Effect of Silk Fibroin Content on Physical and Mechanical Properties of Electrospun Poly(lactic acid)/Silk Fibroin Nanofibers for Meniscus Tissue Engineering Scaffold

Promnil

Ruksakulpiwat

Numpaisal

2022

J. Phys.: Conf. Ser.

View full text Add to dashboard Cite

This study aims to produce composite nanofibers from polylactic acid (PLA) and silk fibroin (SF) with mechanical properties similar to that of a native meniscus. SF is a natural protein, well known for its good biocompatibility and biodegradability but it has poor mechanical properties compared to synthetic polymers. SF contains proteins which can promote cell adhesion and cell proliferation required for a tissue engineering scaffold. PLA is a popular material that is widely used in tissue engineering. It provides high mechanical properties but lacks bioactivity and cell affinity. Thus, a PLA/SF composite scaffold can improve these drawbacks. In this study, PLA/SF nanofibers were fabricated using an electrospinning process at various PLA and SF ratios (PLA: SF 100:0, 75:25, 50:50, and 25:75). The SF content in the emulsion dominated the fiber diameter, fiber arrangement and processibility of nanofibrous scaffold. With increasing SF content, the %elongation at break of PLA/SF scaffold increased but Young’s modulus decreased. The wettability of electrospun PLA was increased with an increase in SF content.

show abstract

“…Such high incidence of chronic and aging-related diseases has increased the demand for highperforming biomaterials and therapeutic strategies envisaging cartilage regeneration [1,2]. Natural polymers have shown several advantages for biomedical applications due to their biodegradability, biocompatibility and cell-recognition ability [3,4]. Silk fibroinbased materials obtained from mulberry silkworm Bombyx mori have been processed in different forms, including 3D scaffolds, nanoparticles, nanofibers and hydrogels [5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Fabrication and characterization of Eri silk fibers-based sponges for biomedical application

Silva

Oliveira

et al. 2016

Acta Biomaterialia

View full text Add to dashboard Cite

This work addresses the preparation and characterization of non-mulberry cocoon-derived Eri silk sponges. The insolubility of cocoons-derived non-mulberry silkworms impairs their processability and applications in the healthcare field. We used a green approach with ionic liquids to overcome the lack solubility of such silk fibers. The formation of beta-sheet structures into Eri-based sponges was physically and chemically induced. The sponges were obtained by freeze-drying. The developed structures exhibited flexibility to adapt and recover their shapes upon application and subsequent removal of load, high swelling degree, ability to load an anti-inflammatory drug and to promote its sustained release. They promoted in vitro cellular adhesion, proliferation and extracellular matrix production of a chondrocyte-like cell line, opening up their potential application for biomedical applications.

show abstract

Polymers of Biological Origin

Cited by 5 publications

References 236 publications

Antibacterial composite hydrogels of graphene quantum dots and bacterial cellulose accelerate wound healing

Antibacterial composite hydrogels of graphene quantum dots and bacterial cellulose accelerate wound healing

Effect of Silk Fibroin Content on Physical and Mechanical Properties of Electrospun Poly(lactic acid)/Silk Fibroin Nanofibers for Meniscus Tissue Engineering Scaffold

Fabrication and characterization of Eri silk fibers-based sponges for biomedical application

Contact Info

Product

Resources

About