Polymers for Bioprinting

Carrow, James K.; Kerativitayanan, Punyavee; Jaiswal, Manish K.; Lokhande, Giriraj; Gaharwar, Akhilesh K.

doi:10.1016/b978-0-12-800972-7.00013-x

Cited by 87 publications

(80 citation statements)

References 76 publications

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“…Aer printing, the alginate component forms nal cross-linking by incubation with calcium ions to retain the designed geometries of hydrogel for in vitro culture and in vivo implantation. 43 The carboxymethyl chitosan component improves the mechanical stability and antibacterial activity of the hydrogel.…”

Section: Printed Cell-laden Hydrogel Scaffoldsmentioning

confidence: 99%

BMSCs-laden gelatin/sodium alginate/carboxymethyl chitosan hydrogel for 3D bioprinting

Huang

Wang

et al. 2016

RSC Adv.

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Three-dimensional (3D) bioprinting technology offers the possibility to deliver, in a defined and organized manner, scaffolding materials and living cells, and therefore holds much promise for tissue engineering and regenerative medicine. In this work, we explored the possibility of gelatin/sodium alginate/carboxymethyl chitosan (Gel/SA/CMCS) hydrogel combining with bone mesenchymal stem cells (BMSCs) for 3Dbioprinting. Compared to the commonly used 3D bioprinting materials such as gelatin/sodium alginate (Gel/SA) hydrogel, the Gel/SA/CMCS hydrogel we developed shows excellent equilibrium water content, good mechanical properties, antibacterial activity, and a slow degradation rate. With this kind of material, we generated a scaffold with homogenous cell distribution. Cell viability after 3D printing showed that over 85% of the printed cells were viable at 0 and 2 days of culturing. Our work demonstrates the feasibility of mixing Gel/SA/CMCS hydrogel with stem cells for 3D bioprinting.

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Section: Printed Cell-laden Hydrogel Scaffoldsmentioning

confidence: 99%

BMSCs-laden gelatin/sodium alginate/carboxymethyl chitosan hydrogel for 3D bioprinting

Huang

Wang

et al. 2016

RSC Adv.

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“…They are categorized as proteins (eg, collagen, gelatin, fibrin, elastin, and silk), polysaccharides (eg, alginate, hyaluronic acid, dextran, cellulose, amylose, and chitin), and polynucleotides . Detailed reviews of natural polymers have been published elsewhere . The combination of the mechanical properties of synthetic polymers with the biological properties of natural polymer presents best option of combining the desired mechanical properties with biological properties to fabricate functional tissue engineering scaffolds …”

Section: Polymersmentioning

confidence: 99%

Multifaceted polymeric materials in three‐dimensional processing (3DP) technologies: Current progress and prospects

Oderinde

Kang

et al. 2018

Polymers for Advanced Techs

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Three‐dimensional printing (3DP) technologies, which are sets of powerful deposition methods employed to fabricate 3D objects with materials in the fields of material sciences and engineering, biomedical and biocompatible structural components, automotive, aviation, and polymers, among others, are currently rapidly developing manufacturing technologies. The methods have significant advantages, which include designing flexibility, enhanced geometrical freedom, low cost, and net shape manufacture, among others, over the traditional “subtractive” method. This review highlights the major 3D printing techniques, especially in the fields of advanced polymeric material fabrication and engineering, as well as the synergy in the incorporation of different types of polymeric materials and composites in a process that will lead to an enhancement of dimensional accuracy for 3D technologies. Furthermore, composite ink systems especially polymer‐based and hydrogel‐based in tissue engineering applications are also discussed.

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“…[6]. PLA is semicrystalline, biodegradable, biocompatible, and has found use in several medical applications like orthopedic implants, drug delivery systems, and biofabrication [7]. PCL is a biodegradable polymer and is widely used to manufacture tissue scaffolds due to its good biocompatibility and excellent mechanical properties [8].…”

Section: Introductionmentioning

confidence: 99%

Effect of Different Porosity Ratio on Mechanical Properties of Polycaprolactone and Polylactic Acid Scaffolds

Demir¹,

Keser²,

Çalışkan³

2018

acperpro

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In recent years, patient-specific solutions and additive manufacturing (AM) have become increasingly important in the treatment of bone defects in studies performed on the medical field. In this direction, additive manufacturing methods use in scaffold fabrication, and many advantages of these systems come to the forefront. Porosity affects the mechanical properties, biocompatibility, and biodegradability of tissue engineering scaffolds. In this study, the effect of different porosity ratios on the mechanical properties of scaffolds for polylactic acid (PLA) and polycaprolactone (PCL) scaffolds was studied. With this fabrication method can be formed entirely three dimensional (3D) interconnected porous scaffolds with pore size. Three different (20%, 35%, and 50%) porosity ratios were determined for both materials, and the mechanical properties of the samples were determined by compression test. The scaffolds fabricated with larger pore size showed lower mechanical performance compared to scaffolds with smaller pore size.

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Polymers for Bioprinting

Cited by 87 publications

References 76 publications

BMSCs-laden gelatin/sodium alginate/carboxymethyl chitosan hydrogel for 3D bioprinting

BMSCs-laden gelatin/sodium alginate/carboxymethyl chitosan hydrogel for 3D bioprinting

Multifaceted polymeric materials in three‐dimensional processing (3DP) technologies: Current progress and prospects

Effect of Different Porosity Ratio on Mechanical Properties of Polycaprolactone and Polylactic Acid Scaffolds

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