Polymers and biopolymers at interfaces

Hall, Amy R.; Geoghegan, Mark

doi:10.1088/1361-6633/aa9e9c

Cited by 28 publications

(22 citation statements)

References 377 publications

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“…The ability to detach "on-demand" provides a different route to creating a host of products that may easily be recycled, as well as extending the capabilities of other goods. 2,5,11 The use of pH to switch the adhesive properties of materials generally involves surfaces being adhered in water so that the addition of an acid or a base causes the bonding to fail. The first demonstration of pH-switchable adhesion was using cationic poly [2-(dimethylamino)ethyl methacrylate] (PDMAEMA) grafted chains adhering to a hemispherical gel of poly(methacrylic acid) (PMAA), which spontaneously failed when the pH was reduced to less than two.…”

Section: Introductionmentioning

confidence: 99%

Adhesion between oppositely charged polyelectrolytes in salt solution

Alfhaid

Williams

Geoghegan

2020

J of Applied Polymer Sci

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The adhesion at the aqueous interface between a polyacid hydrogel and a grafted polycation layer (brush) is shown to be reversible on the addition of sodium chloride, which screens the charges on the gel and brush. Furthermore it is shown that a double-network hydrogel both exhibits adhesive failure and stronger adhesion with the brush than a simple poly(methacrylic acid) [PMAA] hydrogel, whereas the PMAA gel undergoes cohesive failure on detachment. The adhesive force at the hydrogel-brush interface significantly increases after adding dilute salt solution (of 0.001 M). Once the concentration of salt solution is raised above 0.05 M, both the adhesive force and work done in detaching both single-and doublenetwork hydrogels from the brush surface are notably reduced. This result confirms that reversible adhesion between a hydrogel and polymer brush in salt solutions is possible, although a double-network gel is required for adhesive failure.

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Section: Introductionmentioning

confidence: 99%

Adhesion between oppositely charged polyelectrolytes in salt solution

Alfhaid

Williams

Geoghegan

2020

J of Applied Polymer Sci

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“…Atomic force microscopy (AFM) is an established technique for studying the binding between biomolecules (26)(27)(28). In addition to revealing dissociation rates, the AFM can provide information of the character of the bond under external stress, which, in the case of cell-ECM interactions and tissues under flow, may be physiologically relevant.…”

Section: Introductionmentioning

confidence: 99%

Distinct Binding Interactions of α5β1-Integrin and Proteoglycans with Fibronectin

Kennelly

Qwarnström

et al. 2019

Biophysical Journal

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Dynamic single-molecule force spectroscopy was performed to monitor the unbinding of fibronectin with the proteoglycans syndecan-4 (SDC4) and decorin and to compare this with the unbinding characteristics of a 5 b 1-integrin. A single energy barrier was sufficient to describe the unbinding of both SDC4 and decorin from fibronectin, whereas two barriers were observed for the dissociation of a 5 b 1-integrin from fibronectin. The outer (high-affinity) barriers in the interactions of fibronectin with a 5 b 1-integrin and SDC4 are characterized by larger barrier heights and widths and slower dissociation rates than those of the inner (low-affinity) barriers in the interactions of fibronectin with a 5 b 1-integrin and decorin. These results indicate that SDC4 and (ultimately) a 5 b 1-integrin have the ability to withstand deformation in their interactions with fibronectin, whereas the decorinfibronectin interaction is considerably more brittle.

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“…Moreover, interference with its binding in sand ies reveal it as a potent target for transmission blockade. These force spectroscopy data were used to build a map of the spatial distribution of adhesion, 38,39 which revealed a nonhomogeneous distribution for a proportion of parasites, thus contributing to an understanding of the underlying molecular interactions used by Leishmania parasites to colonize their sand y hosts.…”

Section: Introductionmentioning

confidence: 99%