Polymerized vorinostat mediated photodynamic therapy using lysosomal spatiotemporal synchronized drug release complex

Hu, Pengwei; Sun, Miao; Lu, Fengkun; Wang, Sizhen; Hou, Lei; Yu, Yingjie; Zhang, Yunchang; Yao, Jing; Yang, Feng; Wang, Chen; Ma, Zhiqiang

doi:10.1016/j.colsurfb.2021.111903

Cited by 6 publications

(1 citation statement)

References 23 publications

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“…Many previous studies have confirmed the negative role of histone deacetylases (HDAC) in PDT and ferroptosis. The use of HDAC inhibitory drugs can inhibit tumor recurrence and metastasis and induce ferroptosis [77,78]. The photosensitizer QpyNHOH, designed based on the inhibition of HDAC, can directly induce ferroptosis and increase the ROS production rate while simultaneously reversing intratumoral hypoxia and tumor antioxidant capacity [79].…”

Section: Synergistic Effects Of Photodynamic Therapy Combined With Fe...mentioning

confidence: 99%

Photodynamic Therapy Combined with Ferroptosis Is a Synergistic Antitumor Therapy Strategy

Huang,

Li,

Zhang

et al. 2023

Cancers

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Ferroptosis is a programmed death mode that regulates redox homeostasis in cells, and recent studies suggest that it is a promising mode of tumor cell death. Ferroptosis is regulated by iron metabolism, lipid metabolism, and intracellular reducing substances, which is the mechanism basis of its combination with photodynamic therapy (PDT). PDT generates reactive oxygen species (ROS) and 1O2 through type I and type II photochemical reactions, and subsequently induces ferroptosis through the Fenton reaction and the peroxidation of cell membrane lipids. PDT kills tumor cells by generating excessive cytotoxic ROS. Due to the limited laser depth and photosensitizer enrichment, the systemic treatment effect of PDT is not good. Combining PDT with ferroptosis can compensate for these shortcomings. Nanoparticles constructed by photosensitizers and ferroptosis agonists are widely used in the field of combination therapy, and their targeting and biological safety can be improved through modification. These nanoparticles not only directly kill tumor cells but also further exert the synergistic effect of PDT and ferroptosis by activating antitumor immunity, improving the hypoxia microenvironment, and inhibiting the tumor angiogenesis. Ferroptosis-agonist-induced chemotherapy and PDT-induced ablation also have good clinical application prospects. In this review, we summarize the current research progress on PDT and ferroptosis and how PDT and ferroptosis promote each other.

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Section: Synergistic Effects Of Photodynamic Therapy Combined With Fe...mentioning

confidence: 99%

Photodynamic Therapy Combined with Ferroptosis Is a Synergistic Antitumor Therapy Strategy

Huang,

Li,

Zhang

et al. 2023

Cancers

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show abstract

Codelivery of vorinostat and chloroquine by autophagy-inhibitory hollow ZrO2 nanoshells for synergistic combination chemotherapy

Chen

Jia

Xia

et al. 2023

Chemical Engineering Journal

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Lysosomal activable Vorinostat carrier-prodrug self-assembling with BPQDs enables photothermal oncotherapy to reverse tumor thermotolerance and metastasis

Yu¹,

Wang²,

Sun³

et al. 2022

International Journal of Pharmaceutics

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Polymerized vorinostat mediated photodynamic therapy using lysosomal spatiotemporal synchronized drug release complex

Cited by 6 publications

References 23 publications

Photodynamic Therapy Combined with Ferroptosis Is a Synergistic Antitumor Therapy Strategy

Photodynamic Therapy Combined with Ferroptosis Is a Synergistic Antitumor Therapy Strategy

Codelivery of vorinostat and chloroquine by autophagy-inhibitory hollow ZrO2 nanoshells for synergistic combination chemotherapy

Lysosomal activable Vorinostat carrier-prodrug self-assembling with BPQDs enables photothermal oncotherapy to reverse tumor thermotolerance and metastasis

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