Two new Schiff base ligands containing ASiOCH 3 or ASiOCH 2 CH 3 groups, 4-{[(3-trimethoxysilanepropyl)imino]methyl}benzene-1,3-diol (1) Hmsb and 4-{[(3-triethoxysilanepropyl)imino]methyl}benzene-1,3-diol (5) Hesb, have been synthesized by the reaction of 2,4-dihydroxybenzaldehyde with 3-aminopropyltrimethoxysilane and 3-aminopropyltriethoxysilane. Six new transition metal [Cu II , Ni II and Co II ] complexes of these Schiff Base ligands were prepared. The complexes are formed by coordination of N, O atoms of the ligands. Their structures were confirmed by elemental analyses, 1 H nmr, i.r. and u.v.-vis. spectral data. The analytical data shows that the metalto-ligand ratio in the Schiff Base complexes contains silane in 1:2. In addition, the antimicrobial activity of (1) Hmsb and (5) Hesb Schiff ligands, and their [M(msb) 2 ] and [M(esb) 2 ] type coordination compounds, were investigated.