Polymerization‐Induced Self‐Assembly under Compressed CO₂: Control of Morphology Using a CO₂‐Responsive MacroRAFT Agent

Abstract

Polymerization-induced self-assembly of 2-hydroxypropyl methacrylate is conducted in water and water/MeOH using a CO -responsive macroRAFT agent in the form of a statistical copolymer comprising N,N-diethylaminoethyl methacrylate (DEAEMA) and poly(ethylene glycol) methyl ether methacrylate (M = 475 g mol ). Pressurization with CO leads to protonation of DEAEMA units within the stabilizer block, thereby offering a means of adjusting the charge density of the coronal layer. It is demonstrated that a wide range of tunable particle morphologies are accessible by simply varying the CO pressure during polymerization in the range of 10-45 bar.

Nano-assemblies with core-forming hydrophobic polypeptide via polymerization-induced self-assembly (PISA)

“…works well under either dispersion [29][30][31][32][33] or emulsion polymerization conditions [34][35][36][37] and in a wide range of solvents. [38][39][40][41][42][43][44][45] Although the use of PISA is drastically growing due to its advantages, most reports show relatively simple self-assembled morphologies (spheres, worms and vesicles). 25 Inspired by the properties of peptide-based nanostructures as well as PISA approach, we have recently reported the first example of PISA nano-objects derived from self-assembling peptide (SAP) containing polymer.…”

Self-Assembling Peptide—Polymer Nano-Objects via Polymerization-Induced Self-Assembly

“…PISA has been demonstrated to work well under dispersion [10][11][12][13][14] or emulsion polymerization [15][16][17][18] both in polar solvents (water, alcohols, …) [19][20][21][22][23][24][25] or non-polar solvents (alkanes, toluene, …). [26][27][28][29] Less conventional solvents such as ionic liquids 30 or supercritical CO2 [31][32][33] were also successfully used for PISA protocols. Although PISA can result in a large variety of morphologies, spheres, worms or vesicles with controlled size and functionality 2,11,[34][35][36][37][38] are the most common PISA morphologies.…”

Rational synthesis of novel biocompatible thermoresponsive block copolymer worm gels

“…7,8 Thus, if the target diblock composition and other synthesis parameters are optimized, then spherical, 9,10 worm-like [11][12][13] or vesicular 14,15 morphologies can be produced in various solvents using a wide range of vinyl monomers. [16][17][18][19][20][21][22] In particular, PISA via RAFT aqueous dispersion polymerization [23][24][25][26] is ideally suited for the preparation of nano-objects with potential biomedical applications. Such formulations involve the chain extension of a water-soluble precursor using a water-miscible monomer.…”