Polymerization-induced emission (PIE) of multifunctional polyamides synthesized by Ugi polymerization and targeted imaging of lysosomes

Abstract

In this paper, a series of polyamide derivatives (PAMs) containing morpholine groups were prepared by Ugi polymerization from dialdehyde, diacid, N-(2-aminoethyl)-morpholine and isonitrile compounds as the novel multi-responsive fluorescent sensors....

Recent Progress in Nonconventional Luminescent Macromolecules and their Applications

“…110 112 Deng et al prepared a series of polyamide derivatives (PAMs) containing pendent morpholine groups, which endow polymerization-induced emission, and applied them to target imaging trackers and as real-time monitors of changes of Fe 3+ concentration in lysosomes. 113 Tomalia, Klajnert-Maculewicz et al showed that a functionalized PAMAM dendrimer forms a polyplex with double stranded DNA and is nontoxic for HeLa and HMEC-1 cells up to a concentration of 10 mg/mL. The unique intrinsic luminescence properties of the dendrimer revealed that it accumulates in endosomal compartments.…”

“…Ding et al investigated peptidomimetic polyurea derivatives with AIE characteristics for conformation-assisted deformation, discoloration, and intracellular drug delivery with effective cancer theranosis in vitro and in vivo . Deng et al prepared a series of polyamide derivatives (PAMs) containing pendent morpholine groups, which endow polymerization-induced emission, and applied them to target imaging trackers and as real-time monitors of changes of Fe 3+ concentration in lysosomes . Tomalia, Klajnert-Maculewicz et al showed that a functionalized PAMAM dendrimer forms a polyplex with double stranded DNA and is nontoxic for HeLa and HMEC-1 cells up to a concentration of 10 mg/mL.…”