Polymeric sulfated surfactants with varied hydrocarbon tail: II. Chemical selectivity in micellar electrokinetic chromatography using linear solvation energy relationships study

Akbay, Cevdet; Shamsi, Shahab A.

doi:10.1002/elps.200305764

Cited by 18 publications

(22 citation statements)

References 36 publications

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“…Linear solvation energy relationships were conducted to predict the selectivity differences between the four sulfated polymeric surfactants. The overall nature of the solute/polymeric micelle interactions was found to be different, despite the fact that all polymeric surfactants have the same head group [20]. The effects of the polymeric surfactant chain length have also been reported utilizing polyallyamine [21,22] and polysiloxane [23,24] phases, but only for achiral separations.…”

Section: Introductionmentioning

confidence: 94%

“…Very recently our group investigated the effect of hydrocarbon chain length on chemical selectivity in MEKC for achiral separation of 36 benzene derivatives using polymeric sulfated surfactants [19,20]. Linear solvation energy relationships were conducted to predict the selectivity differences between the four sulfated polymeric surfactants.…”

Section: Introductionmentioning

confidence: 99%

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Polymeric alkenoxy amino acid surfactants: IV. Effects of hydrophobic chain length and degree of polymerization of molecular micelles on chiral separation of β-blockers

Rizvi

Shamsi

2005

Electrophoresis

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Four alkenoxy leucine-based surfactants with C8-C11 chains containing a terminal double bond, and one C11 chain surfactant with a terminal triple bond are synthesized and characterized in monomeric and polymeric forms. These polymeric pseudophases are then utilized to study the influence of chain length and DP for the enantioseparations of seven beta-blockers in MEKC. Variations in chain length and concentration of polymeric surfactants showed significant effects on the chiral resolution (Rs) and efficiency (N). A relatively large elution range combined with the highest polarity and aggregation number (A) but the lowest retention time, partial specific volume, and optical rotation generated with C8-polymeric surfactant results in simultaneous enantioseparation of all seven beta-blockers with higher N and R(s). In particular, highly hydrophobic beta-blockers are better resolved with shorter hydrocarbon chain even at higher surfactant concentration, which is unachievable with longer chain surfactant. On the other hand, polymer derived from C11-triple bond provided smaller A value compared to C11-double bond surfactant. However, chiral Rs of hydrophobic beta-blockers are still achievable with the C11-triple bond surfactant with enhanced N and shorter analysis time. In addition, effect of polymerization concentration is evaluated by polymerizing all five surfactants at five times their respective CMCs and 100 mM equivalent monomer concentrations. Polymerization of shorter chain (C8 and C9) double-bonded surfactants at five times their respective CMCs results in higher A values with better chiral Rs and N compared to the same two surfactants polymerized at 100 mM.

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Section: Introductionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Polymeric alkenoxy amino acid surfactants: IV. Effects of hydrophobic chain length and degree of polymerization of molecular micelles on chiral separation of β-blockers

Rizvi

Shamsi

2005

Electrophoresis

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“…The capacity factor (k 0 ) of all neutral solutes as well as the electroosmotic mobility (m EOF ), apparent electrophoretic mobility (m a ), and effective mobility (m e ) of surfactant monomers and polymers were calculated as previously reported [20,21]. Methanol was used as the t 0 marker and decanophenone was used to measure t mc .…”

Section: Calculationsmentioning

confidence: 99%

“…In addition to the surfactant head group, effects of hydrocarbon chain length of both conventional surfactants [11][12][13][14] and polymeric surfactants [15][16][17][18][19][20][21] on chemical selectivity have been investigated. While the effects of the polar head group of amino acid-based polymeric surfactants have received considerable attention, these studies have been limited to chiral separations [22][23][24][25][26][27].…”

Section: Introductionmentioning

confidence: 99%

Glycine-based polymeric surfactants with varied polar head group: I. Synthesis, characterization, and application in micellar electrokinetic chromatography

2005

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The monomers and polymers of four anionic amide type sodium undecenoxy carbonyl glycinate (SUCG) surfactants and four anionic carbamate type sodium undecenoyl glycinate (SUG) surfactants with 1-, 2-, 3-, and 4-glycine unit as head group were synthesized and characterized. The CMC and aggregation number (A) for all eight surfactants were determined using fluorescence spectroscopy. In addition, the CMC values of these surfactants were also projected by surface tension and CE. The CMC of the monomers decreases with increases in the size of glycine head groups and correlates well when the fluorescence method was compared to CE. The A number increases and partial specific volume (V) decreases with increase in size of the head group of both monomers and polymers. However, A and V are always lower for the polymers than the corresponding monomers. The electrophoretic and chromatographic parameters of micelle polymers of SUG and SUCG were also examined. The coefficient of EOF increases with the increase in size of the head group but the electrophoretic mobility decreases which results in a decrease in the elution range. The retention data suggest that the selectivity differences among the mono-, di-, and tripeptide derivatives of poly-SUCG surfactants are relatively higher compared to the derivatives of poly-SUG series.

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“…Akbay and Shamsi [20,21] studied analogs of sodium undecenyl sulfate with varied alkyl chain length from eight to eleven carbons both before and after polymerization. In the first of these reports, the authors noted that the CMC of the surfactants decreased as expected as the alkyl chain length was increased, and that the polymers of longer alkyl chain surfactants have lower polarity and provide a greater migration range [21].…”

Section: Polymeric Sulfate Surfactantsmentioning

confidence: 99%

Recent progress in the use of soluble ionic polymers as pseudostationary phases for electrokinetic chromatography

Palmer

McCarney

2004

Electrophoresis

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This review concerns the development, characterization, and application of soluble ionic polymeric materials as pseudostationary phases for electrokinetic chromatography since 2002. Cationic polymers, anionic siloxanes, polymerized surfactants (micelle polymers), and chiral polymers are considered. The use of stable suspensions of polymer nanoparticles in electrokinetic chromatography is also reviewed.

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Polymeric sulfated surfactants with varied hydrocarbon tail: II. Chemical selectivity in micellar electrokinetic chromatography using linear solvation energy relationships study

Cited by 18 publications

References 36 publications

Polymeric alkenoxy amino acid surfactants: IV. Effects of hydrophobic chain length and degree of polymerization of molecular micelles on chiral separation of β-blockers

Polymeric alkenoxy amino acid surfactants: IV. Effects of hydrophobic chain length and degree of polymerization of molecular micelles on chiral separation of β-blockers

Glycine-based polymeric surfactants with varied polar head group: I. Synthesis, characterization, and application in micellar electrokinetic chromatography

Recent progress in the use of soluble ionic polymers as pseudostationary phases for electrokinetic chromatography

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