Polymeric particulate technologies for oral drug delivery and targeting: a pathophysiological perspective

Hunter, A. Christy; Elsom, Jacqueline; Wibroe, Peter P.; Moghimi, S. Moein

doi:10.1016/j.nano.2012.07.005

Cited by 79 publications

(24 citation statements)

References 180 publications

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“…An exciting development of universal 'magic bullet' nanoparticle-based drug delivery system to brain [61] , the key objectives to be considered are size of particles [62] , surface properties as well as discharge of drugs [63] or the active ingredient to accomplish highest efficacy [64] . The nanoparticle sizes range from 10-100 nm is preferred for targeted delivery in brain, however the nanoparticle sizes less than 230 nm with a polydispersity of 0.10 were also used for brain delivery [65] .…”

Section: Various Drug Targeting Strategies To Brainmentioning

confidence: 99%

Effect of Surfactant Coating on Brain Targeting Polymeric Nanoparticles; a Review

Chacko¹,

Palanisamy²,

Gowrishankar³

et al. 2018

pharmaceutical-sciences

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Chacko, et al.: Surfactant Coating on Brain Targeting NanoparticlesTargeting of drugs to brain is one of the most challenging issues for pharmaceutical research as bloodbrain barrier acts as an insurmountable obstacle for the passage of systemically delivered therapeutics and the brain extracellular matrix attributes to poor distribution of locally delivered drugs. Amongst various invasive or non-invasive methods to warrant blood-brain barrier, nanoparticle is one of promising ways to administer central nervous system drugs. The concept of nanoparticle-based drug targeting make a tremendous progress and gigantic era to overcome the above limitations with improved drug efficacy and reduced drug toxicity. In recent years, new strategies of surfactant coating of biodegradable polymeric nanoparticles, which differ from conventional methodologies of brain targeting, have emerged at the forefront of medical science. The non-ionic surfactant, polysorbate 80 as a coating material promises an unparalleled opportunity for enhancement of brain targeting of colloidal particles. The aim of this review is to evaluate the potential application of surfactant-coated nanoparticles as drug carrier system for various central nervous system diseases.

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Section: Various Drug Targeting Strategies To Brainmentioning

confidence: 99%

Effect of Surfactant Coating on Brain Targeting Polymeric Nanoparticles; a Review

Chacko¹,

Palanisamy²,

Gowrishankar³

et al. 2018

pharmaceutical-sciences

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“…18 The gastrointestinal tract (GIT) has a large mucosal interface (300-400 m 2 ), which is also designed for physiological and immunological protection of this external environment. 19 The detailed scrutiny of foreign entities is achieved by a complex interaction between epithelial cells and a variety of immunocompetent cells and may be modulated by gut microbiota.…”

Section: The Gastrointestinal Tractmentioning

confidence: 99%

“…There is also an important gap in the application to site specific smart polymer targeting of areas within the GIT for immunological benefit, such as Payer's patches. 18 Importantly, this is a safe environment to use these polymer technologies as millions of tablets using smart polymer coating are used on a daily basis worldwide in a safe and effective fashion.…”

Section: Mucoadhesionmentioning

confidence: 99%

Smart polymers in drug delivery: a biological perspective

Hunter

Moghimi

2017

Polym. Chem.

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Key to the widespread application of smart polymers in drug delivery is understanding the mechanistic interplay, as well as consequence, of the presence of these macromolecules within living systems. This review looks at these interactions in terms of host response to macromolecular structure and subsequent clinical implications. In order to highlight this, three distinct routes of drug delivery are discussed, enabling a journey from the outside of the body in to the cell. This is used to contrast the need for different scientific approaches replete to successful drug delivery in these physiologically diverse areas. The discussion initiates with the application of smart polymers to the oral route of drug delivery, followed by macromolecular fate within the systemic circulation and finally intracellular delivery. The advantages, in terms of biological performance, as well as the challenges of using smart polymers within this multifaceted arena are delineated.

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“…Moreover, a high number of in vivo explorations have been conducted in rodent models, which cannot fully mimic the complexity of the human physiology (e.g., intestine length) and human diseases [64].…”

Section: In Vitro and In Vivo Responses To Bio-based Nanostructuresmentioning

confidence: 99%

Edible Bio-Based Nanostructures: Delivery, Absorption and Potential Toxicity

et al. 2015

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The development of bio-based nanostructures as nanocarriers of bioactive compounds to specific body sites has been presented as a hot topic in food, pharmaceutical and nanotechnology fields. Food and pharmaceutical industries seek to explore the huge potential of these nanostructures, once they can be entirely composed of biocompatible and non-toxic materials. At the same time, they allow the incorporation of lipophilic and hydrophilic bioactive compounds protecting them against degradation, maintaining its active and functional performance. Nevertheless, the physicochemical properties of such structures (e.g., size and charge) could change significantly their behavior in the gastrointestinal (GI) tract. The main challenges in the development of these nanostructures are the proper characterization and understanding of the processes occurring at their surface, when in contact with living systems. This is crucial to 2 understand their delivery and absorption behavior as well as to recognize potential toxicological effects. This review will provide an insight into the recent innovations and challenges in the field of delivery via GI tract using bio-based nanostructures. Also, an overview of the approaches followed to ensure an effective deliver (e.g., avoiding physiological barriers) and to enhance stability and absorptive intestinal uptake of bioactive compounds will be provided. Information about nanostructures' potential toxicity and a concise description of the in vitro and in vivo toxicity studies will also be given.

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Polymeric particulate technologies for oral drug delivery and targeting: a pathophysiological perspective

Cited by 79 publications

References 180 publications

Effect of Surfactant Coating on Brain Targeting Polymeric Nanoparticles; a Review

Effect of Surfactant Coating on Brain Targeting Polymeric Nanoparticles; a Review

Smart polymers in drug delivery: a biological perspective

Edible Bio-Based Nanostructures: Delivery, Absorption and Potential Toxicity

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