Polymeric nanosystems for the delivery of antitumor and antituberculosis drug preparations

Burkeev, M. Zh.; Tazhbayev, Yerkeblan; Zhaparova, L.Zh.; Kreuter, Jörg

doi:10.15328/chemb_2013_258-64

Cited by 1 publication

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“…Jointly with research group of the Institute of Pharmaceutical Technology of Goethe University by the scientists of Kazakhstan under the leadership of prof. Burkeev M.Zh. HSA nanoparticles loaded with antitumor drug Arglabin and antiTB drug p-amino salicylic acid (PASA) have been synthesized by the desolvation method [136,137]. Both forms of antitumor drug Arglabin -hydrophobic native (substance) arglabin and dimethylaminoarglabin hydrochloride have been used for immobilization into the matrix of HSA.…”

Section: Loading Efficiencymentioning

confidence: 99%

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Nanoencapsulation of Antitumor and Antituberculosis Drug Preparations with Biocompatible Polymers

Burkeev

Kreuter

Herk

et al. 2014

J. Res. Updates Polym. Sci.

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Controlled release of drugs at the locus of the targeted disease is one of the most challenging research areas in the pharmaceutical field. Nowadays novel drug delivery systems on the basis of polymers are attracting great attention since they can improve therapeutic efficiency of potent drug preparations decreasing the risk of side effects. By developing colloidal drug delivery systems such as liposomes/vesicles and polymeric nanoparticles and nanocapsules the pharmacokinetics of the drug can be changed and thus the therapeutic efficiency of the drug can be increased. Nanoparticles with their special characteristics such as small particle size, large surface area and high capacity of carrying biologically active substances offer a number of advantages compared to other colloidal drug delivery systems [1,2].Controlled drug release systems are constructed on the basis of natural and biocompatible synthetic polymers. Among the most promising biocompatible polymers human serum albumin (HSA), polyalkyl cyanoacrylates (PACA) and poly-D,L-lactic acid (PLA) are of great importance. Nanoparticles on their basis have been proven to be efficient in treatment of serious and long-termed diseases such as tumors, tuberculosis and bacterial infections . Therefore this article is aimed to give a brief review on the research works devoted to the synthesis and investigation of polymeric nanoparticles and nanocapsules based on PACA, HSA and PLA for the past three decades.

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Section: Loading Efficiencymentioning

confidence: 99%

“…The nanoparticles based on HSA loaded with the antitumor drug Arglabin and antiTB drug PASA allowed to attain high loading efficiency for both drugs, which shows the perspective of using nanoparticulate forms of these drugs [136,137]. Dependence of binding degree on the concentration of added PASA is shown on the graph (Figure 7).…”

Section: Loading Efficiencymentioning

confidence: 99%