Polymeric nanospheres for topical delivery of vitamin D3

Ramezanli, Tannaz; Kilfoyle, Brian E.; Zhang, Zheng; Michniak‐Kohn, Bozena

doi:10.1016/j.ijpharm.2016.10.072

Cited by 64 publications

(33 citation statements)

References 38 publications

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“…VD 3 has been successfully formulated and administrated transdermally and subcutaneously by using different vehicles, including nanocarriers [37][38][39]. However, our proposed system presents a potential advantage, which is reduction of the administration frequency.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Novel bilayer dissolving microneedle arrays with concentrated PLGA nano-microparticles for targeted intradermal delivery: Proof of concept

Vora

Donnelly

Larrañeta

et al. 2017

Journal of Controlled Release

125

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Polymeric microneedle (MN) arrays continue to receive growing attention due to their ability to bypass the skin's stratum corneum barrier in a minimally-invasive fashion and achieve enhanced transdermal drug delivery and "targeted" intradermal vaccine administration. In this research work, we fabricated biodegradable bilayer MN arrays containing nano - microparticles for targeted and sustained intradermal drug delivery. For this study, model drug (vitamin D, VD)-loaded PLGA nano- and microparticles (NMP) were prepared by a single emulsion solvent evaporation method with 72.8% encapsulation of VD. The prepared NMP were directly mixed 20% w/v poly(vinyl pyrrolidone) (PVP) gel, with the mixture filled into laser engineered micromoulds by high-speed centrifugation (30min) to concentrate NMP into MN shafts. The particle size of PLGA NMP ranged from 300nm to 3.5μm and they retained their particle size after moulding of bilayer MN arrays. The relatively wide particle size distribution of PLGA NMP was shown to be important in producing a compact structure in bilayer conical, as well as pyramidal, MN, as confirmed by scanning electron microscopy. The drug release profile from PLGA NMP was tri-phasic, being sustained over 5days. The height of bilayer MN arrays was influenced by the weight ratio of NMP and 20% w/v PVP. Good mechanical and insertion profiles (into a skin simulant and excised neonatal porcine skin) were confirmed by texture analysis and optical coherence tomography, respectively. Ex vivo intradermal neonatal porcine skin penetration of VD NMP from bilayer MN was quantitatively analysed after cryostatic skin sectioning, with 74.2±9.18% of VD loading delivered intradermally. The two-stage novel processing strategy developed here provides a simple and easy method for localising particulate delivery systems into dissolving MN. Such systems may serve as promising means for controlled transdermal delivery and targeted intradermal administration.

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Section: Accepted Manuscriptmentioning

confidence: 99%

Novel bilayer dissolving microneedle arrays with concentrated PLGA nano-microparticles for targeted intradermal delivery: Proof of concept

Vora

Donnelly

Larrañeta

et al. 2017

Journal of Controlled Release

125

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“…Another therapeutic approach, the encapsulation of antipsoriatic agents in nanoparticles [ 109 , 110 ], is currently under study with the aim of improving the efficacy, safety, and compliance of potential agents.…”

Section: Future Directionsmentioning

confidence: 99%

Contribution ofIn Vivoand Organotypic 3D Models to Understanding the Role of Macrophages and Neutrophils in the Pathogenesis of Psoriasis

Lorthois

Asselineau

Seyler³

et al. 2017

Mediators of Inflammation

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Psoriasis, a common chronic immune-mediated skin disease, is histologically characterized by a rapid keratinocyte turnover and differentiation defects. Key insights favor the idea that T cells are not the only key actors involved in the inflammatory process. Innate immune cells, more precisely neutrophils and macrophages, provide specific signals involved in the initiation and the maintenance of the pathogenesis. Current data from animal models and, to a lesser extent, three-dimensional in vitro models have confirmed the interest in leaning towards other immune cell types as a potential new cellular target for the treatment of the disease. Although these models do not mimic the complex phenotype nor all human features of psoriasis, their development is necessary and essential to better understand reciprocal interactions between skin cells and innate immune cells and to emphasize the crucial importance of the local lesional microenvironment. In this review, through the use of in vivo and 3D organotypic models, we aim to shed light on the crosstalk between epithelial and immune components and to discuss the role of secreted inflammatory molecules in the development of this chronic skin disease.

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“…According to the polymeric components, polymeric nanoparticles may be configurated as nanocapsules or nanospheres. The former have an oil or water core surrounded by a polymeric matrix, allowing physical stability enhancement and the protection of the loaded drug [72,73]. MXD nanocapsules enhance the hair growth, due to the increment in number and length of hair follicles during the anagen phase.…”

Section: Polymeric Nanoparticlesmentioning

confidence: 99%

Topical Minoxidil-Loaded Nanotechnology Strategies for Alopecia

et al. 2020

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Androgenetic alopecia (AGA) is a multifactorial and age-related condition characterized by substantial hair loss affecting both men and women. Conventional treatments include the use of topical minoxidil (MNX) formulations to stimulate hair growth and restore hair condition. However, those treatments are associated with limited performance and a lack of tolerability and compliance due to the emergence of adverse effects. Considering that the development of nanotechnology-based formulations as hair loss therapeutic strategies has been clearly growing, topical MNX delivery by means of these innovative formulations is known to enhance MNX skin permeation and depot formation into hair follicles, allowing for MNX-controlled release, increased MNX skin bioavailability and enhanced therapeutic efficacy with minimal adverse effects. This review highlights the potential of nanotechnology-based MNX delivery formulations for improved hair loss therapeutics, including a thorough assessment of their in vitro and in vivo performances, as well as regulatory and nanosafety considerations.

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Polymeric nanospheres for topical delivery of vitamin D3

Cited by 64 publications

References 38 publications

Novel bilayer dissolving microneedle arrays with concentrated PLGA nano-microparticles for targeted intradermal delivery: Proof of concept

Novel bilayer dissolving microneedle arrays with concentrated PLGA nano-microparticles for targeted intradermal delivery: Proof of concept

Contribution ofIn Vivoand Organotypic 3D Models to Understanding the Role of Macrophages and Neutrophils in the Pathogenesis of Psoriasis

Topical Minoxidil-Loaded Nanotechnology Strategies for Alopecia

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