Polymeric nanoparticulate system: A potential approach for ocular drug delivery

Nagarwal, Ramesh C.; Kant, Shri; Singh, Priya; Maiti, Pralay; Pandit, J. K.

doi:10.1016/j.jconrel.2008.12.018

Cited by 421 publications

(226 citation statements)

References 89 publications

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“…4 Nanopartículas contendo polímeros hidrofóbicos pré-formados invariavelmente necessitam de solvente orgânico, utilizado para a solubilização do polímero, e podem eventualmente desnaturar o ácido nucleico utilizado. 28 Nanopartículas lipídicas sólidas são estruturas formadas por lipídios que são sólidos em temperatura ambiente e temperatura corporal. 29,30 Existem basicamente dois métodos de preparo: homogeneização à alta pressão e o método de microemulsão.…”

Section: Vetores Não Virais Com Base Nanotecnológica Para a Via Ocularunclassified

Biomateriais para formulações de base nanotecnológica visando terapia gênica ocular

et al. 2016

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Section: Vetores Não Virais Com Base Nanotecnológica Para a Via Ocularunclassified

Biomateriais para formulações de base nanotecnológica visando terapia gênica ocular

et al. 2016

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“…The development of effective drug delivery systems that can transport and deliver a drug precisely and safely to its site of action is becoming a highly important research area for pharmaceutical researchers [34] . Various efforts in ocular drug delivery have been made to improve the bioavailability and to prolong the residence time of drugs applied topically onto the eye [35] . New alternative approach is to develop a drug delivery system that would circumvent the problems associated with the conventional systems, and provide the advantages of targeted delivery of drugs for extended periods of time and be patient-friendly.…”

Section: Nanotechnology Based Ocular Drug Deliverymentioning

confidence: 99%

Lipid Nanoparticles for Ocular Drug Delivery

Okur

Gökçe

2015

International Journal of Ophthalmic Research

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Despite numerous scientific efforts, efficient ocular drug delivery remains a challenge for pharmaceutical scientists. Delivery of ophthalmic drugs to the targeted ocular tissues is limited by many precorneal, dynamic and static ocular barriers. The anatomy, physiology and biochemistry of the eye render this organ exquisitely impervious to foreign substances. One of the promising strategies nowadays is the use of colloidal carrier systems characterized by a submicron-meter size. Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) represent promising alternatives to conventional and very popular ocular carrier systems.

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“…The degree of deacetylation in commercial Chs is in the range of 60-100 %. The tremendous potential of Ch in the pharmaceutical area is illustrated in several review articles (Alonso & Sanchez, 2009;Nagarwal et al, 2009;Dodane & Vilivalam, 1998;Felt et al, 1998;Paul & Sharma, 2000;Singla & Chawla, 2001. These point out that Ch is biodegradable, has low toxicity and good ocular tolerability, exhibits bioadhesion and permeability-enhancing properties and also physico-chemical characteristics that make it suitable for the design of ocular drug delivery vehicles.…”

Section: Chitosan and Its Derivativesmentioning

confidence: 99%

“…The ocular retention of drugs administered by eye drops is also potentially improved by colloidal drug carriers, such as liposomes, submicron emulsions, nanoparticles and nanocapsules. The drugs are incorporated into these submicron particles which can be internalized into the corneal and/or conjunctival cells of the ocular epithelium (Alonso & Sanchez, 2009;Nagarwal et al, 2009). Prolonging the residence of drugs in the precorneal area serves either the extra-or intraocular therapy.…”

Section: Introductionmentioning

confidence: 99%