Polymeric Nanoparticles via Noncovalent Cross-Linking of Linear Chains

Seo, Myungeun; Beck, Benjamin J.; Paulusse, Jos M. J.; Hawker, Craig J.; Kim, Sang Youl

doi:10.1021/ma8009678

Cited by 159 publications

(146 citation statements)

References 82 publications

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“…[197] The behaviour observed was strongly dependent on the level of incorporation of the dendritic monomers.…”

Section: Microgels and Nanoparticlesmentioning

confidence: 98%

“…St [184] MMA [88] 323 [185] 40 [186] S S O O St [186] St-b-MAH [186] St-b-MAH-b-NIPAM [186] 41* [187,188] S S (MMA) [64,187,189] BA [187] EHA [188] St [190] TBAM [191] DEAM [187] DMAM [187] NAM [191] NIPAM [187,189] BA/St [192] EHA-b-MA [188] TBAM-b-NAM [191] DMAM/NAS [193] NAM-b-TBAM [191] 42* S S Ph CN MMA [194] 376 [195] 376-b-MMA [195] BA [196] MMA [189] NIPAM [189] MMA-b-NIPAM [189] MMA/283 [197] MMA/284 [197] St/2VP [198] St/348 [199] THPA-b-St [200] THPA-b-St/373 [201] 44 [202] [200] 47 [203] …”

Section: Choice Of Raft Agentsmentioning

confidence: 99%

“…[96] N O O 278 [96] O O N N O O MMBL 279 [258] O [124,145] 281 [124] O [197] O F 3 C F 3 C CONH 2 CONH 2 284 [197] [158] 294 [125] N O O N N CN 295 [126] O O O N OH 296 [127] [436] O O O O 299 [317] O O O O O OH 300 [455] [456] TPMMA 302 [92] O O 303 [203] O O S 304 [140] …”

Section: End-functional Polymers and End-group Transformationsunclassified

See 2 more Smart Citations

Living Radical Polymerization by the RAFT Process - A Second Update

Moad¹,

Rizzardo²,

Thang³

2009

Aust. J. Chem.

902

720

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This paper provides a second update to the review of reversible deactivation radical polymerization achieved with thiocarbonylthio compounds (ZC(=S)SR) by a mechanism of reversible addition-fragmentation chain transfer (RAFT) that was published in June 2005 (Aust. J. Chem. 2005, 58, 379-410). The first update was published in November 2006 (Aust. J. Chem. 2006, 59, 669-692). This review cites over 500 papers that appeared during the period mid-2006 to mid-2009 covering various aspects of RAFT polymerization ranging from reagent synthesis and properties, kinetics and mechanism of polymerization, novel polymer syntheses and a diverse range of applications. Significant developments have occurred, particularly in the areas of novel RAFT agents, techniques for end-group removal and transformation, the production of micro/nanoparticles and modified surfaces, and biopolymer conjugates both for therapeutic and diagnostic applications.

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“…[197] The behaviour observed was strongly dependent on the level of incorporation of the dendritic monomers.…”

Section: Microgels and Nanoparticlesmentioning

confidence: 98%

Section: Choice Of Raft Agentsmentioning

confidence: 99%

See 1 more Smart Citation

Living Radical Polymerization by the RAFT Process - A Second Update

Moad¹,

Rizzardo²,

Thang³

2009

Aust. J. Chem.

902

720

View full text Add to dashboard Cite

show abstract

“…Reactive functional groups NC/DC bonding interactions Benzamide [26] Benzamide hydrogen bonding * 2-Ureido-Pyrimidone (UPy) [43] UPy dimerization * Coumarin [35] Coumarin photo-dimerization ** Benzaldehyde [32] Acylhydrazone formation ** -Ketoester [27] Enamine formation ** Methyl viologen + Naphtyl [37] Cucurbit[n]uril complexation * L-Phenylalanine (Phe) [55] Hydrophobic Phe-Phe interactions * Aminophenyl disulfide [44] Disulfide formation ** * NC bonding interactions. ** DC bonding interactions.…”

Section: Reactive Functional Groupsmentioning

confidence: 99%

Advances in Click Chemistry for Single-Chain Nanoparticle Construction

2013

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Single-chain polymeric nanoparticles are artificial folded soft nano-objects of ultra-small size which have recently gained prominence in nanoscience and nanotechnology due to their exceptional and sometimes unique properties. This review focuses on the current state of the investigations of click chemistry techniques for highly-efficient single-chain nanoparticle construction. Additionally, recent progress achieved for the use of well-defined single-chain nanoparticles in some promising fields, such as nanomedicine and catalysis, is highlighted.

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“…1,[9][10][11][12][13][14][15] Like other living radical polymerizations, [16][17][18][19] reversible addition-fragmentation chain transfer polymerization (RAFT) has been increasingly used to create functional polymers and architectures for biological and nanotechnology applications. 9,10, Polymers synthesized by RAFT polymerization contain thiocarbonylthio end groups that can impart instability to the final polymers.…”

Section: Introductionmentioning

confidence: 99%

Modification of RAFT‐polymers via thiol‐ene reactions: A general route to functional polymers and new architectures

Boyer

Granville

Davis

et al. 2009

J. Polym. Sci. A Polym. Chem.

237

240

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An investigation into the aminolysis of x-end groups of RAFT-polymers and simultaneous thiol-ene reactions with ene-bearing compounds is described. Three different polymers, P(MMA), P(HPMA), and P(NIPAAm), with low PDIs were synthesized using dithiobenzoate and trithiocarbonate RAFT agents. P(NIPAAm) synthesized with trithiocarbonate RAFT agent and P(HPMA) synthesized with dithiobenzoate RAFT agent were both functionalized with a methacrylate-modified mannose and a maleimide-modified biotin via one-pot simultaneous aminolysis and thiol-ene reactions with product yields above 85%. The presence of ene-compounds during aminolysis was shown to prevent the formation of disulfide interchain crosslinking. Using the same approach, P(MMA), P(HPMA), and P(NIPAAm) were converted to (meth)acrylate macromonomers with high yields ([80%). In the case of P(MMA), the simultaneous aminolysis and thiol-ene addition prevented any intrachain side reactions, i.e., thiolactone formation. New architectures such as graft and block copolymers were successfully generated from the macromonomers.

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Polymeric Nanoparticles via Noncovalent Cross-Linking of Linear Chains

Cited by 159 publications

References 82 publications

Living Radical Polymerization by the RAFT Process - A Second Update

Living Radical Polymerization by the RAFT Process - A Second Update

Advances in Click Chemistry for Single-Chain Nanoparticle Construction

Modification of RAFT‐polymers via thiol‐ene reactions: A general route to functional polymers and new architectures

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