Polymeric Nanoparticles to Combat Squamous Cell Carcinomas in Patients with Dystrophic Epidermolysis Bullosa

Abstract

Skin cancer is the leading cause of malignancy in the United States, with Basal Cell Carcinoma, Squamous Cell Carcinoma , and Melanoma being the three most common diagnoses, respectively. Squamous Cell Carcinoma (SCC) is a particular concern for patients suffering from Dystrophic Epidermolysis Bullosa (DEB), a disease that affects the production and function of collagen VII, a protein that forms the anchoring fibrils which bind the epidermis to the dermis. Patients with DEB suffer from chronic blistering and wounds that have impaired healing capabilities, often leading to the development of SCC and eventual mortality. Nanomedicine is playing an increasing role in the delivery of effective therapeutics to combat a wide range of diseases, including the imaging and treatment of SCC. In this review, we discuss the role of nanoparticles in the treatment of SCC with an emphasis on PLGA nanoparticles and SCCs found in patients suffering from DEB, and address recent patents that are pertinent to the development of novel nanomedical therapeutics.

Unraveling the ECM-Immune Cell Crosstalk in Skin Diseases

“…Similarly, doxorubicin-loaded cationic solid lipid nanoparticles (DOX-SLN) have shown better drug penetration and inhibition of skin cancer tumor growth (Huber et al, 2015). In RDEB, localized delivery of gold nanoparticle coated with epigallocatechin-3-gallate (E3G) in SCC tumor site has been shown to abrogate the adverse effect of the drug in the liver (Manoukian et al, 2014). Additionally in EB, a novel nanocapsule based wound dressing technique has been developed.…”

Topical Administration of Ibuprofen for Injured Athletes: Considerations, Formulations, and Comparison to Oral Delivery

“…Dissolvable microneedles can cross the stratum corneum without damaging dermal nerves and blood vessels in order to deliver drugs in a similar manner to transdermal patches. They have repeatedly been demonstrated to be an efficient way of directly introducing pharmaceuticals into the dermis, including small molecules, vaccines, and even large proteins [ 67 – 70 ]. Similarly, ibuprofen-laden dissolvable microneedles have been shown to deliver local ibuprofen sodium effectively into rats [ 71 ].…”

Organic Nanomaterials and Their Applications in the Treatment of Oral Diseases

“…Of interest also is the fact that PLGA nanocarriers have been developed to deliver active molecules for other possible dental-related applications: transport of dexamethasone for gingival fibroblasts differentiation [149] or controlled release of amphotericin B for fighting against fungal infections [150]. Novel skin cancer treatments could include PLGA NPs [163] transporting small molecules, RNA or genes in order to target the p53 inactivation or the epidermal growth factor receptor over-expression in skin squamous carcinoma tumors [164]. Taking into account the numerous experiments involving PLGA and PLGA-derived nanoparticles used for diagnosis or treatment of other types of tumors [13,165,166,167,168], an increase in research regarding PLGA nanoparticles uses in the oral cancer field is expected.…”