Polymeric Nanocomplex Encapsulating Iron Oxide Nanoparticles in Constant Size for Controllable Magnetic Field Reactivity

Chun, Sang Hun; Shin, Seung Won; Amornkitbamrung, Lunjakorn; Ahn, So Yeon; Yuk, Ji Soo; Sim, Sang Jun; Luo, Dan; Um, Soong Ho

doi:10.1021/acs.langmuir.7b04143

Cited by 11 publications

(3 citation statements)

References 36 publications

(48 reference statements)

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“…PEGylated-PLGA polymer coating of IONs was carried out by a single emulsion-solvent evaporation method (20). Briefly, 2 mg of IONs and 20 mg PEGylated-PLGA polymers were mixed in 4 mL DCM, forming the emulsion's organic phase.…”

Section: Fabrication Of Pegylated-plga Coated Monodisperse Ionsmentioning

confidence: 99%

Hyperthermia Efficacy of PEGylated-PLGA Coated Monodisperse Iron Oxide Nanoparticles

Senturk

2023

Hittite Journal of Science and Engineering

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Magnetic nano hyperthermia (MNH) is a promising technique for the treatment of a variety of malignancies. This non-invasive technique employs magnetic nanoparticles and alternating magnetic fields to generate local heat at the tumor location, which activates cell death pathways. However, the efficacy of MNH is dependent on the physicochemical properties of the magnetic nanoparticles, such as size, size distribution, magnetic properties, biocompatibility, and dispersibility in the medium. In this study, it is aimed to evaluate the heating capacity of poly (lactic-co-glycolic acid)-poly (ethylene glycol) di-block copolymer (PLGA-b-PEG) coated monodisperse iron oxide nanoparticles (IONs) as an effective mediator for MNH application. For this purpose, monodisperse IONs with a narrow size distribution and a mean particle size of 8.6 nm have been synthesized via the thermal decomposition method. The resulting IONs were then coated with the PEGylated-PLGA polymer and homogeneously dispersed in the polymeric matrix, which had a clearly defined spherical shape. Additionally, the specific absorption rate (SAR), reflecting the amount of heat dissipation from the NPs to the surrounding medium, was calculated for different concentrations (10, 5, 2.5, and 1.25 mg/mL) of PEGylated-PLGA-IONs. At 5 mg/mL PEGylated-PLGA-IONs (125 μgFe/mL) were found to have a maximum SAR value of 313 W/g. In conclusion, the homogenous dispersion of IONs in PEGylated-PLGA matrix may be one of the critical parameters to enhance the SAR value for MNH-based cancer therapy.

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Section: Fabrication Of Pegylated-plga Coated Monodisperse Ionsmentioning

confidence: 99%

Hyperthermia Efficacy of PEGylated-PLGA Coated Monodisperse Iron Oxide Nanoparticles

Senturk

2023

Hittite Journal of Science and Engineering

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“…The production of hybrid nanomaterials by the insertion of MNPs in a polymeric matrix is another type of encapsulation currently used. [187] Following this strategy, iron oxides NPs have been encapsulated in poly(lactic-co-glycolic acid) (PLGA) by emulsion-evaporation method; [188] and in similar systems obtained by coaxial electrospray. [189] PLGA microparticles were also generated by the second technique for the encapsulation of chitosan-capped gold NPs.…”

Section: Capping By Encapsulationmentioning

confidence: 99%

The Use of Capping Agents in the Stabilization and Functionalization of Metallic Nanoparticles for Biomedical Applications

Pedroso‐Santana

Fleitas‐Salazar

2022

Part & Part Syst Charact

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The study of nanoparticles (NPs) and their application in different areas of research, including biomedicine, is attracting the attention of researchers worldwide. Numerous investigations published during the last 20 years cover the fabrication of new materials in the nanoscale, and several uses have been proposed. Metallic nanoparticles (MNPs) have generated a high level of interest, based on improved optical, electrical and magnetic properties, ease of manufacturing, small sizes, and easy functionalization. However, when it comes to Biomedicine, particle aggregation, possible toxicity, and the need for effective cell internalization, still demand active investigation. The main strategy to overcome these drawbacks is possibly the use of capping agents to increase the stability of the particles in dispersion, their biocompatibility and functionalization. In this review, important concepts and characteristics of MNPs, are collected and described. The importance of surface coating for biomedical applications of metallic nanoparticles as well as the most used capping agents and metallic nanomaterials, are also discussed. Finally, the text includes examples and essential characteristics for the biomedical use of MNPs, including the consideration of important challenges. Aspects such as relevant biological activity, increased biocompatibility and functionalization potential are among the most desirable attributes of a capping agent.

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“…The term nanoparticle commonly refers to an organic or inorganic particle with a size of 1–100 nm. Due to the rapid development of nanotechnology, nanoparticles can be easily manufactured with various sizes and shapes and even tailored with some functionalities for eventual use in several fields including medicine and food engineering [33–35]. Intracellular delivery of antagonist RNAs for gene regulation by RNA interference has mostly been achieved with the help of nanoparticle carriers.…”

Section: Nanomaterials With Biological Relevancementioning

confidence: 99%

Regulation of cellular gene expression by nanomaterials

Chun

Yuk

2018

Nano Convergence

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Within a cell there are several mechanisms to regulate gene expression during cellular metabolism, growth, and differentiation. If these do not work properly, the cells will die or develop abnormally and, in some cases, even develop into tumors. Thus, a variety of exogenous and endogenous approaches have been developed that act on essential stages of transcription and translation by affecting the regulation of gene expression in an intended manner. To date, some anticancer strategies have focused on targeting abnormally overexpressed genes termed oncogenes, which have lost the ability to tune gene expression. With the rapid advent of nanotechnology, a few synthetic nanomaterials are being used as gene regulation systems. In many cases, these materials have been employed as nanocarriers to deliver key molecules such as silencing RNAs or antisense oligonucleotides into target cells, but some nanomaterials may be able to effectively modulate gene expression due to their characteristic properties, which include tunable physicochemical properties due to their malleable size and shape. This technology has improved the performance of existing approaches for regulating gene expression and led to the development of new types of advanced regulatory systems. In this short review, we will present some nanomaterials currently used in novel gene regulation systems, focusing on their basic features and practical applications. Based on these findings, it is further envisioned that next-generation gene expression regulation systems involving such nanomaterials will be developed.

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Polymeric Nanocomplex Encapsulating Iron Oxide Nanoparticles in Constant Size for Controllable Magnetic Field Reactivity

Cited by 11 publications

References 36 publications

Hyperthermia Efficacy of PEGylated-PLGA Coated Monodisperse Iron Oxide Nanoparticles

Hyperthermia Efficacy of PEGylated-PLGA Coated Monodisperse Iron Oxide Nanoparticles

The Use of Capping Agents in the Stabilization and Functionalization of Metallic Nanoparticles for Biomedical Applications

Regulation of cellular gene expression by nanomaterials

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