Polymeric Nanocarriers Based on Cyclodextrins for Drug Delivery: Host–Guest Interaction as Stimuli Responsive Linker

Peng, Liao; Liu, Senyang; Feng, Anchao; Yuan, Jinying

doi:10.1021/acs.molpharmaceut.7b00160

Cited by 101 publications

(66 citation statements)

References 136 publications

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“…It can interact with many guests with suitable sizes and are considered as good choices for the applications in drug delivery systems due to their adjustable water solubility, good biocompatibility, and nontoxicity toward biological systems. Moreover, CDs can reduce the toxicity of the drug molecules and of the grafted polymers and to bring additional benefits such as membrane absorption enhancement, molecular stabilization, and improvement of water solubility as well as the availability of drugs in biological systems (Peng et al 2017). Actually, the conjugation of PSs with these non-toxic molecules showed improvement on their amphiphilicity, biocompatibility and availability at the surface of cancer cell membranes (Mazzaglia et al 2003, Sortino et al 2006.…”

Section: Cancer Pdt and Porphyrin-type Derivatives 1003mentioning

confidence: 99%

Cancer, Photodynamic Therapy and Porphyrin-Type Derivatives

Gomes

Cavaleiro

2018

An. Acad. Bras. Ciênc.

106

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This review has two parts. The first one gives an approach to interdisciplinary studies against cancer carried out by many scientists using porphyrin-type substrates as photosensitizers in PDT. Intensive studies were performed for almost six decades. The successes really started in 1993 with the first formulation patented under the trade name Photofrin, which was immediately approved in several countries to treat certain types of cancer. Photofrin is still used although certain negative features soon became well known. That has motivated the search for better new photosensitizers. Several ones were developed, evaluated and a few of them had clinical approval. This group includes porphyrin derivatives and pro-drugs (aminolevulinic acid and its alkyl esters). Oncological, dermatological and ophthalmic applications are now taking place for the benefit of mankind. The second part of this review is related with the work carried out in Aveiro at the authors University on the synthesis and biological evaluation of several potential PDT photosensitizers. Not only new synthetic methodologies mainly for porphyrins and chlorins were developed but also other related macrocycles of the phthalocyanine and corrole types have entered in the same "pipeline". In vivo and in vitro biological evaluations also took place under interdisciplinary studies.

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Section: Cancer Pdt and Porphyrin-type Derivatives 1003mentioning

confidence: 99%

Cancer, Photodynamic Therapy and Porphyrin-Type Derivatives

Gomes

Cavaleiro

2018

An. Acad. Bras. Ciênc.

106

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“…Furthermore, stimulus-response can be induced by use of basic guest molecules that are not protonated and uncharged and form inclusion complexes with CDs at higherp H. At lower pH, these guest molecules are protonateda nd positively chargeda nd hence unlikely to enter the hydrophobic CD cavity.As uitable guest molecule is benzimidazole, which can bind to b-CD at high pH values but leaves the b-CD cavity upon protonation in an acidic environment. [27] The pH-dependent decomplexation is especially advantageous for applica-tions in drug delivery systemsa nd experimentalt umor treatment due to the fact that diseased tissue possesses lower pH values than healthy tissue.…”

Section: Introductionmentioning

confidence: 99%

Stimulus‐Responsive Assembly of Nanoparticles using Host–Guest Interactions of Cyclodextrins

Engel

Möller

Ravoo

2018

Chemistry A European J

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The design of multifunctional nanomaterials that respond to external stimuli and mimic the capacity of biological materials to respond and adapt to their environment has become a focus of interest in nanotechnology. In this Concept, we describe the development of supramolecular nanoparticle assemblies constructed by use of host-guest interactions between cyclodextrins and suitable guest molecules. The nanoparticle assembly is reversible and can be directed by applying different stimuli that act either on the guest molecules or the nanoparticles. This strategy can be extended to mesoscale assembly of microparticles. We highlight the newest research work in this field of nanochemistry and point out future perspectives and opportunities.

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“…Furthermore, SCs with ap rocessed amphiphilic nature or responsive properties can self-assemble into different morphologies, such as micelles and vesicles,s ot hat they can be applied in the drug-delivery field. [31][32][33] Aside for the traditional drug-loadeds trategy, the application of supramolecular prodrug self-assemblies with better safety and intelligent behaviorh as recently attracted attention. [31][32][33] Aside for the traditional drug-loadeds trategy, the application of supramolecular prodrug self-assemblies with better safety and intelligent behaviorh as recently attracted attention.…”

Section: Introductionmentioning

confidence: 99%

Photo‐ and pH‐ Dual‐Responsive β‐Cyclodextrin‐Based Supramolecular Prodrug Complex Self‐Assemblies for Programmed Drug Delivery

Bai

Liu

Song

et al. 2018

Chemistry An Asian Journal

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Despite the fact that progress has been made in the application of supramolecular prodrug self-assembliest o enhance the functionality of drug-delivery systems, corresponding research on multi-responsive supramolecular prodrug self-assemblies for programmedd rug delivery is still limited. In this paper,t he synthesis and self-assembly behavior of supramolecularp rodrug complexes( SPCs) with b-cyclodextrin-acylhydrazone-doxorubicin (b-CD-hydrazone-DOX) and the targeting of azobenzene-terminated poly[2-(dimethylamino)ethyl methacrylate] (Azo-PDMA-FA) as a building block were investigated. The obtained SPCs could also form self-assemblies on the basis of their amphiphilic nature. Next, SPC-based multi-compartment vesiclesa nd complex micelles, which were confirmed by transmission electron microscopy and dynamic/static light scattering, were obtained with good reversibility under alternative visible light or UV irradiation. Furthermore, three-stage programmed drug-delivery behavior was observed from dual-re-sponsiveS PC-based self-assemblies by utilizing UV and pH stimuli.S pecifically,t he SPCs first self-assembled into multicompartmental vesicles, which was accompanied by as low releaseo fD OX. Next, UV-light irradiation induced the dissociation of b-CD/Azo,w hich led to morphologyt ransition and as light increaseinthe rate of releaseofDOX. Upon transferring the self-assemblies to phosphate-buffer solution (pH 5.0), the releaser ates increased notably as ar esult of the broken acylhydrazone bond. Finally,b asic cell experiments further demonstrated that the SPC-based self-assemblies could be internalized into cancerc ells, which suggests their promise for applicationsinc ancer therapy.Scheme1.Morphology transition of supramolecular prodrugcomplex self-assemblies and their programmed drug-release behaviorregulated by UV lighta nd pH.

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Polymeric Nanocarriers Based on Cyclodextrins for Drug Delivery: Host–Guest Interaction as Stimuli Responsive Linker

Cited by 101 publications

References 136 publications

Cancer, Photodynamic Therapy and Porphyrin-Type Derivatives

Cancer, Photodynamic Therapy and Porphyrin-Type Derivatives

Stimulus‐Responsive Assembly of Nanoparticles using Host–Guest Interactions of Cyclodextrins

Photo‐ and pH‐ Dual‐Responsive β‐Cyclodextrin‐Based Supramolecular Prodrug Complex Self‐Assemblies for Programmed Drug Delivery

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