Polymeric microspheres: a delivery system for osteogenic differentiation

Patel, Rajkumar; Patel, Madhumita; Kwak, Jeonghun; Iyer, Arun K.; Karpoormath, Rajshekhar; Desai, Shrojal M.; Rarh, Vimal

doi:10.1002/pat.4084

Cited by 11 publications

(3 citation statements)

References 121 publications

(160 reference statements)

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“…To date, bioactive inorganics, polymers, and composites are used to manufacture scaffolds. [5][6][7][8][9][10] FDA-approved poly(lactic-coglycolic acid) (PLGA) has good biocompatibility and is often prepared as scaffolds or microspheres for bone tissue repair. [11][12][13][14] Compared with 3D bulk framework scaffolds, microspheres can be directly injected to fill defects of different shapes without causing secondary damage.…”

Section: Introductionmentioning

confidence: 99%

PLGA Cage‐Like Structures Loaded with Sr/Mg‐Doped Hydroxyapatite for Repairing Osteoporotic Bone Defects

Sun

Liu

et al. 2022

Macromolecular Bioscience

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Poly(lactic-co-glycolic acid) (PLGA)-based porous structures have a widespread application in bone defects. To solve its flaws in the bone application, hydroxyapatite (HA) is often introduced into PLGA-based systems, and ion doping endows HA with more biological activity. In osteoporotic bone defects, the decreased activity of osteoblasts and the hyperactive osteoclasts results in slow bone repair. Strontium (Sr) can promote bone regeneration and inhibit bone resorption and has been used in the treatment of osteoporosis. Magnesium (Mg) cannot only enhance the regeneration of bone tissue but also vessels. In this study,the aim is to fabricate a multifunctional porous structure that can promote osteogenesis, and angiogenesis and inhibit osteoclasts for repairing osteoporotic bone defects. PLGA cage-like structures loaded with Sr-and Mg-doped HA (Sr/Mg@HA/PLGA-CAS) are prepared; they have large pores, suitable hydrophilicity, and can continuously release Mg 2+ and Sr 2+ , which facilitate cell adhesion and growth. The results show that Sr/Mg@HA/PLGA-CAS can motivate the osteogenic activity of osteoblast precursor cells and angiogenic ability of endothelial cells, and suppress osteoclast differentiation in vitro. This study indicates that Sr/Mg@HA/PLGA-CAS can assist osteogenesis, and angiogenesis while restraining osteoclast differentiation, which may have a potential application value in osteoporotic bone defects.

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Section: Introductionmentioning

confidence: 99%

PLGA Cage‐Like Structures Loaded with Sr/Mg‐Doped Hydroxyapatite for Repairing Osteoporotic Bone Defects

Sun

Liu

et al. 2022

Macromolecular Bioscience

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“…Strategy that sequentially releases growth factor and differentiation factor is commonly used [8,[17][18][19][20][21]. As per our knowledge, several review literatures have been published related to PLGA microspheres for biomedical applications [22][23][24][25]. However, a smaller number of reviews have been reported on the PLGA core-shell microsphere [26,27].…”

Section: Introductionmentioning

confidence: 99%

PLGA Core-Shell Nano/Microparticle Delivery System for Biomedical Application

Patel

2021

Polymers

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Core–shell particles are very well known for their unique features. Their distinctive inner core and outer shell structure allowed promising biomedical applications at both nanometer and micrometer scales. The primary role of core–shell particles is to deliver the loaded drugs as they are capable of sequence-controlled release and provide protection of drugs. Among other biomedical polymers, poly (lactic-co-glycolic acid) (PLGA), a food and drug administration (FDA)-approved polymer, has been recognized for the vehicle material. This review introduces PLGA core–shell nano/microparticles and summarizes various drug-delivery systems based on these particles for cancer therapy and tissue regeneration. Tissue regeneration mainly includes bone, cartilage, and periodontal regeneration.

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“…Furthermore, nanoparticles have been broadly utilized as drug delivery systems for targeted delivery of anticancer drugs [ 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 ] in the pharmaceutical industry. They can enhance the delivery of hydrophobic drugs, decrease metabolic degradation of these drugs, target their delivery to malignant cancer cells just by the alteration of the surface of the delivery system with the addition of a ligand, and show controlled, extended or sustained delivery of drugs [ 7 , 8 , 13 , 25 , 53 , 58 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 ].…”

Section: Introductionmentioning

confidence: 99%

Copper-Free ‘Click’ Chemistry-Based Synthesis and Characterization of Carbonic Anhydrase-IX Anchored Albumin-Paclitaxel Nanoparticles for Targeting Tumor Hypoxia

Tatiparti

Gawde

et al. 2018

IJMS

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Triple negative breast cancer (TNBC) is a difficult to treat disease due to the absence of the three unique receptors estrogen, progesterone and herceptin-2 (HER-2). To improve the current therapy and overcome the resistance of TNBC, there is unmet need to develop an effective targeted therapy. In this regard, one of the logical and economical approaches is to develop a tumor hypoxia-targeting drug formulation platform for selective delivery of payload to the drug-resistant and invasive cell population of TNBC tumors. Toward this, we developed a Carbonic Anhydrase IX (CA IX) receptor targeting human serum albumin (HSA) carriers to deliver the potent anticancer drug, Paclitaxel (PTX). We used Acetazolamide (ATZ), a small molecule ligand of CA IX to selectively deliver HSA-PTX in TNBC cells. A novel method of synthesis involving copper free ‘click’ chemistry (Dibenzocyclooctyl, DBCO) moiety with an azide-labeled reaction partner, known as Strain-Promoted Alkyne Azide Cycloaddition (SPAAC) along with a desolvation method for PTX loading were used in the present study to arrive at the CA IX selective nano-carriers, HSA-PTX-ATZ. The anticancer effect of HSA-PTX-ATZ is higher compared to HSA, PTX and non-targeted HSA-PTX in MDA-MB-231 and MDA-MB-468 cells. The cell killing effect is associated with induction of early and late phases of apoptosis. Overall, our proof-of-concept study shows a promising avenue for hypoxia-targeted drug delivery that can be adapted to several types of cancers.

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Polymeric microspheres: a delivery system for osteogenic differentiation

Cited by 11 publications

References 121 publications

PLGA Cage‐Like Structures Loaded with Sr/Mg‐Doped Hydroxyapatite for Repairing Osteoporotic Bone Defects

PLGA Cage‐Like Structures Loaded with Sr/Mg‐Doped Hydroxyapatite for Repairing Osteoporotic Bone Defects

PLGA Core-Shell Nano/Microparticle Delivery System for Biomedical Application

Copper-Free ‘Click’ Chemistry-Based Synthesis and Characterization of Carbonic Anhydrase-IX Anchored Albumin-Paclitaxel Nanoparticles for Targeting Tumor Hypoxia

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