Polymeric microneedles based enzymatic electrodes for electrochemical biosensing of glucose and lactic acid

Caliò, Alessandro; Dardano, Principia; Palma, V. Di; Bevilacqua, Maria; Matteo, Andrea Di; Iuele, Helena; Stefano, Luca De

doi:10.1016/j.snb.2016.05.156

Cited by 100 publications

(55 citation statements)

References 25 publications

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“…Although different analytical methods have been used for glucose monitoring, electrochemical methods are a more attractive choice, due to their simple operation, high sensitivity, and good selectivity . Currently, glucose biosensors based on electrochemical enzymatic reaction have been most widely used due to their selectivity, simplicity, and reliability . However, a high cost of enzymes, instability, critical operating condition and limited life time of the sensors are the major drawbacks .…”

Section: Introductionmentioning

confidence: 99%

Facile Synthesis of Ni(OH)₂ Modified Disposable Pencil Graphite Electrode and its Application for Highly Sensitive Non‐enzymatic Glucose Sensor

et al. 2018

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In this study, a low‐cost, disposable, sensitive and selective electrochemical sensor was developed for glucose determination, which is based on a pencil graphite electrode (PGE) modified with nickel hydroxide. Cyclic voltammetry was used to deposit nickel on PGE. The morphology and composition of the unmodified and modified PGE electrodes were characterized by field‐emission scanning electron microscopy (FE‐SEM), atomic force microscopy (AFM) and energy‐dispersive X‐ray spectroscopy (EDX). The performance of the as modified electrode towards the electrooxidation of glucose in alkaline media was evaluated with cyclic voltammetry and amperometry techniques. A linear relationship between the concentration of glucose and oxidation peak currents was observed in two concentration ranges of 0.004–3.5 mM and 3.5–9.0 mM. The detection limit was 2 μM at signal‐to‐noise ratio of 3. In addition to a fast response time (<2 s), the proposed sensor preserved 93 % of its original response towards glucose after 28 days. Also, the sensor showed a good reproducibility and high selectivity for glucose oxidation in the presence of common interfering species. The use of Ni(OH)2/PGE sensor was successfully tested in the determination of glucose in human blood serum for the first time in the literature.

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Section: Introductionmentioning

confidence: 99%

Facile Synthesis of Ni(OH)₂ Modified Disposable Pencil Graphite Electrode and its Application for Highly Sensitive Non‐enzymatic Glucose Sensor

et al. 2018

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“…For optimizing temperature. Cyclic voltammetric was measured in microneedles with GOD at a potential of À0.1 V to 1.2 V (versus Ag/AgCl electrode), scan rate of 100 mV s À1 , 11.1 mM glucose, and pH 7.4 in electrolyte, at 25,30,35,40,45, 50 C.…”

Section: Electrochemical Performancementioning

confidence: 99%

Silk/polyols/GOD microneedle based electrochemical biosensor for continuous glucose monitoring

et al. 2020

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“…[19][20][21] If the geometry of the system and few process parameters, such as the time exposure and lamp power, are changed, different shapes (cylindrical, conical, or lancet-like) and lengths (from 100 up to 2000 µm) of MNs can be achieved. PEGDA, poured into a silicone vessel and exposed to ultraviolet light (365 nm) through a mask cross-links in the presence of a commercial photocatalyzer.…”

Section: Industrial or Handmade Manufacture?mentioning

confidence: 99%

Polymeric Microneedle Arrays: Versatile Tools for an Innovative Approach to Drug Administration

Dardano

Battisti²,

Rea

et al. 2019

Advanced Therapeutics

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Mainly designed and realized as a painless alternative to the hypodermic syringe, microneedle-based devices are currently approaching commercial market placement. The considerable academic and industrial investment in this technology is reflected by a multitude of papers published and patents registered every year, which is also a sign of a field in full fermentation. New materials and innovative methodologies are continuously exploited in search of the best performance at the lowest cost. For these reasons, an updated review, focused predominantly on the last year of scientific production, is a useful guideline in this rapidly changing panorama. This report provides a critical review of microneedle technologies presented in the very recent literature with a particular focus on those closest to the needs of the healthcare field. Although a few devices are already commercial, further effort is still needed to achieve complete clinical translation and therapeutic efficacy competitive with or superior to those of the devices used as standards and adopted by national health systems.

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Polymeric microneedles based enzymatic electrodes for electrochemical biosensing of glucose and lactic acid

Cited by 100 publications

References 25 publications

Facile Synthesis of Ni(OH)₂ Modified Disposable Pencil Graphite Electrode and its Application for Highly Sensitive Non‐enzymatic Glucose Sensor

Facile Synthesis of Ni(OH)₂ Modified Disposable Pencil Graphite Electrode and its Application for Highly Sensitive Non‐enzymatic Glucose Sensor

Silk/polyols/GOD microneedle based electrochemical biosensor for continuous glucose monitoring

Polymeric Microneedle Arrays: Versatile Tools for an Innovative Approach to Drug Administration

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Polymeric microneedles based enzymatic electrodes for electrochemical biosensing of glucose and lactic acid

Cited by 100 publications

References 25 publications

Facile Synthesis of Ni(OH)2 Modified Disposable Pencil Graphite Electrode and its Application for Highly Sensitive Non‐enzymatic Glucose Sensor

Facile Synthesis of Ni(OH)2 Modified Disposable Pencil Graphite Electrode and its Application for Highly Sensitive Non‐enzymatic Glucose Sensor

Silk/polyols/GOD microneedle based electrochemical biosensor for continuous glucose monitoring

Polymeric Microneedle Arrays: Versatile Tools for an Innovative Approach to Drug Administration

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Product

Resources

About

Facile Synthesis of Ni(OH)₂ Modified Disposable Pencil Graphite Electrode and its Application for Highly Sensitive Non‐enzymatic Glucose Sensor

Facile Synthesis of Ni(OH)₂ Modified Disposable Pencil Graphite Electrode and its Application for Highly Sensitive Non‐enzymatic Glucose Sensor