Polymeric microcapsules with light responsive properties for encapsulation and release

Bédard, Matthieu F.; Geest, Bruno G. De; Skirtach, André G.; Möhwald, Helmuth; Sukhorukov, Gleb B.

doi:10.1016/j.cis.2009.07.007

Cited by 176 publications

(133 citation statements)

References 178 publications

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“…Polymer containers based on the LbL technique have recently attracted high interest for a variety of different applications, ranging from drug delivery systems and targeted gene therapy to biosensor devices. [19,20] To date, capsules have been made of synthetic and biodegradable polyelectrolytes, [21,22] comprising natural molecules such as oligonucleotides [23] and proteins, [24,25] which demonstrates the high versatility of LbL assembly. Using standard LbL preparation techniques [18] and employing supercharged proteins E57 and K48 as building blocks, we generated capsules exhibiting the following wall structure: (DEXS/pARG)(E57/K48) 3 (E57/K48 AF488 )E57, where DEXS denotes dextran sulfate and pARG poly-(L-arginine), two charged biodegradable polymers made from naturally occurring monomers (see Supporting Information).…”

Section: Capsule Preparation and Characterizationmentioning

confidence: 99%

De Novo Design of Supercharged, Unfolded Protein Polymers, and Their Assembly into Supramolecular Aggregates

Kolbe

Mercato

Abbasi

et al. 2010

Macromol. Rapid Commun.

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Here we report for the first time the design and expression of highly charged, unfolded protein polymers based on elastin‐like peptides (ELPs). Positively and negatively charged variants were achieved by introducing lysine and glutamic acid residues, respectively, within the repetitive pentapeptide units. Subsequently it was demonstrated that the monodisperse protein polyelectrolytes with precisely defined amino acid compositions, sequences, and stereochemistries can be transferred into superstructures exploiting their electrostatic interactions. Hollow capsules were assembled from oppositely charged protein chains by using the layer‐by‐layer technique. The structures of the capsules were analyzed by various microscopy techniques revealing the fabrication of multilayer containers. Due to their low toxicity in comparison to other polyelectrolytes, supercharged ELPs are appealing candidates for the construction of electrostatically induced scaffolds in biomedicine. magnified image

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Section: Capsule Preparation and Characterizationmentioning

confidence: 99%

De Novo Design of Supercharged, Unfolded Protein Polymers, and Their Assembly into Supramolecular Aggregates

Kolbe

Mercato

Abbasi

et al. 2010

Macromol. Rapid Commun.

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“…Recent studies report the production of pH sensitive microcapsules for use in concrete [9,10]. Another release mechanism is the gradual decomposition of light sensitive microcapsules, for a variety of wavelengths, with many applications in cosmetics and agricultural industries [11].…”

Section: Introductionmentioning

confidence: 99%

Polymeric microcapsules with switchable mechanical properties for self-healing concrete: synthesis, characterisation and proof of concept

Kanellopoulos

Palmer²,

Kerr³

et al. 2017

Smart Mater. Struct.

123

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Microcapsules, with sodium silicate solution as core, were produced using complex coacervation in a double, oil-in-water-in oil, emulsion system. The shell material was a gelatin-acacia gum crosslinked coacervate and the produced microcapsules had diameters ranging from 300 to 700 μm. The shell material designed with switchable mechanical properties. When it is hydrated exhibits soft and 'rubbery' behaviour and, when dried, transitions to a stiff and 'glassy' material. The microcapsules survived drying and rehydrating cycles and preserved their structural integrity when exposed to highly alkaline solutions that mimic the pH environment of concrete. Microscopy revealed that the shell thickness of the microcapsules varies across their perimeter from 5 to 20 μm. Thermal analysis showed that the produced microcapsules were very stable up to 190°C. Proof of concept investigation has demonstrated that the microcapsules successfully survive and function when exposed to a cement-based matrix. Observations showed that the microcapsules survive mixing with cement and rupture successfully upon crack formation releasing the encapsulated sodium silicate solution.

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“…Whilst the LBL assembly technique allows the design and modification of hollow microcapsules in a controllable way, the impregnation of the capsule shell with gold nanoparticles (AuNPs) is undoubtedly one of the most attractive ways to tailor their functionality [4][5][6][7]. For example, laser-induced remote drug release is based on localized heating due to surface plasmon resonance absorption by the nanoparticles [8][9][10]. Extensive research has also been carried out into the light sensitivity of AuNP modified PMLCs, and force deformation experiments have shown an improvement in the shell stiffness due to doping with AuNPs [11].…”

Section: Introductionmentioning

confidence: 99%

The effect of gold nanoparticles on the impedance of microcapsules visualized by scanning photo-induced impedance microscopy

Wang

Campos

et al. 2016

Electrochimica Acta

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Abstract:Polyelectrolyte microcapsules have attracted great interest in drug delivery applications, and microcapsules modified with gold nanoparticles have been used in this way with triggered release when a laser can be used to remotely open shells through light-induced local heating. The electrical impedance of unmodified microcapsules has been studied due to its implications for their permeability, however, the impedance of functionalised microcapsules has not yet been investigated. Herein, the impedance of microcapsules modified with gold nanoparticles was studied for the first time. It was shown that the modification of microcapsules with gold nanoparticles leads to a much greater impedance than would be expected from the increase in the thickness caused by the presence of a layer of gold nanoparticles alone. The impedance of gold nanoparticle modified capsules was measured using scanning photo-induced impedance microscopy 2 (SPIM), which is based on photocurrent measurements at an electrolyte-insulatorsemiconductor (EIS) field-effect structure. High resolution and good sensitivity were achieved using a two-photon effect for charge carrier excitation and organic monolayer modified silicon on sapphire (SOS) as the SPIM substrate. SPIM allowed impedance imaging of collapsed microcapsules with unprecedented detail. SPIM images of capsules labelled with gold nanoparticles (AuNPs) showed a good agreement with the corresponding optical images, including the creases resulting from the collapse of the hollow shells. The significant increase in impedance caused by the impregnation with AuNPs was also verified by conductive Atomic Force Microscopy (C-AFM) measurements in the dry state.

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Polymeric microcapsules with light responsive properties for encapsulation and release

Cited by 176 publications

References 178 publications

De Novo Design of Supercharged, Unfolded Protein Polymers, and Their Assembly into Supramolecular Aggregates

De Novo Design of Supercharged, Unfolded Protein Polymers, and Their Assembly into Supramolecular Aggregates

Polymeric microcapsules with switchable mechanical properties for self-healing concrete: synthesis, characterisation and proof of concept

The effect of gold nanoparticles on the impedance of microcapsules visualized by scanning photo-induced impedance microscopy

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