Polymeric Micelles with Endosome Escape and Redox-Responsive Functions for Enhanced Intracellular Drug Delivery

Liu, Jing; Ai, Xixi; Zhang, Huaping; Zhuo, Weiling; Mi, Peng

doi:10.1166/jbn.2019.2693

Cited by 22 publications

(12 citation statements)

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“…As a key point of BNCT, the 10 B enriched compounds must reach at least 30 μg 10 B g −1 of tumor to meet an optimal neutron fluency throughout the period of irradiation [1, 2] . However, the clinically used boron compounds, such as boronophenylalanine (BPA) and sodium borocaptate (BSH) exhibit low cellular uptake, low boron content, limited permeability across the brain‐blood barrier (BBB) hampered its application for effective tumor BNCT [3] . To solve those problems, different kinds of nanomaterials including emulsions, [4] liposomes, [5] dendrimers, [6] graphene‐based systems, [7] quantum dots, [8, 9] carbon nanotubes, [10, 11] and gold nanoclusters [12] have been conjugated to 10 B enriched compounds as smart cargoes [13] .…”

Section: Methodsmentioning

confidence: 99%

“…[1,2] However,t he clinically used boron compounds, such as boronophenylalanine (BPA) and sodium borocaptate (BSH) exhibit low cellular uptake, low boron content, limited permeability across the brain-blood barrier (BBB) hampered its application for effective tumor BNCT. [3] To solve those problems, different kinds of nanomaterials including emulsions, [4] liposomes, [5] dendrimers, [6] graphenebased systems, [7] quantum dots, [8,9] carbon nanotubes, [10,11] and gold nanoclusters [12] have been conjugatedt o 10 Be nriched compounds as smart cargoes. [13] Nonetheless, on average, only 0.7 %o ft he NPs introduced in ap atient's body reach the tumor.…”

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confidence: 99%

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Designed Boron‐Rich Polymeric Nanoparticles Based on Nano‐ion Pairing for Boron Delivery

Janoušková

Fernandez‐Alvarez

et al. 2020

Chemistry A European J

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Boron‐rich particles with the boron fraction ca.10–20 wt % of controllable shape and size that can be easily prepared via simple ion co‐assembly are promising material for tumor treatment by boron neutron capture therapy. Electroneutral, dynamic core‐shell polymeric nanoparticles were prepared by co‐assembly of cationic PEO‐block‐PGEA diblock copolymer with sodium closo‐dodecaborate, Na2[B12H12]. This is the first example of polymer nanoparticles based on [B12H12]2−nano‐ion pairing. The high [B12H12]2− loading is proven by calorimetry at physiological salt concentration. As a result of rational design, rod‐, worm‐ and sphere‐like particles were produced and further tested using human glioblastoma and cervical carcinoma cell lines. Rod‐like particles yielded the highest internalization capability in all tested cell lines.

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Section: Methodsmentioning

confidence: 99%

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confidence: 99%

Designed Boron‐Rich Polymeric Nanoparticles Based on Nano‐ion Pairing for Boron Delivery

Janoušková

Fernandez‐Alvarez

et al. 2020

Chemistry A European J

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“…The stable boron delivery agents with low and high molecular weight connected with a tumor-targeting component or moiety via a hydrolytically stable linkage (boron carriers) belong to this group of compounds ( Figure 2). In particular, these thirdgeneration boron compounds include boronated DNA intercalators [30], boronated amino acids [31], boronated lipopeptides [32], boronated peptides [33], boronated folate receptor [34], boronated epidermal growth factor (EGF) or epidermal growth factor receptor (EGFR) monoclonal antibodies (MAbs) [35], boron-containing immunoliposomes [36] and liposomes [37,38], BSH-loaded polymeric micelles [39], transferrin-polyethylene glycol liposomes [40], maleimide-functionalized closo-dodecaborate albumin conjugates [41], carboranyl nucleosides [42], boronated porphyrins [43], boron-containing nanoparticles [44] coupled with cationic microbubble-assisted focused ultrasound (MB+FUS) treatment [45], pentanuclear porphyrazine complexes [46], boronated cyclic peptides [47], and boron nitride nanotubes [48].…”

Section: Third-generation Boron Compoundsmentioning

confidence: 99%

Boron neutron capture therapy: Current status and future perspectives

Дымова

Taskaev

Richter

et al. 2020

Cancer Communications

175

173

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The development of new accelerators has given a new impetus to the development of new drugs and treatment technologies using boron neutron capture therapy (BNCT). We analyzed the current status and future directions of BNCT for cancer treatment, as well as the main issues related to its introduction. This review highlights the principles of BNCT and the key milestones in its development: new boron delivery drugs and different types of charged particle accelerators are described; several important aspects of BNCT implementation are discussed. BCNT could be used alone or in combination with chemotherapy and radiotherapy, and it is evaluated in light of the outlined issues. For the speedy implementation of BCNT in medical practice, it is necessary to develop more selective boron delivery agents and to generate an epithermal neutron beam with definite characteristics. Pharmacological companies and research laboratories should have access to accelerators for large‐scale screening of new, more specific boron delivery agents.

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“…Disulfide bonds provided the possibility for controlled release inside targeting tumor cells. Notably, Mi et al explored intracellular delivery of 10 B‐compounds via conjugation of sodium borocaptate (BSH) onto PEG‐ b ‐PLGA with disulfide linkages, which was demonstrated to allow the significantly improved ablation of tumors after neutron irradiation (Liu, Ai, Zhang, Zhuo, & Mi, ; Mi et al, ). In addition to direct conjugation of anticancer drugs by disulfide bonds, they are also frequently used to construct core or shell cross‐linked BCP micelles to improve the stability of the nanoparticles under physiological condition, which can be dissociated in the cellular environment (Jia, Wong, Davis, & Bulmus, ).…”

Section: Reduction‐responsive Linkage In Bcpsmentioning

confidence: 99%

Block copolymer prodrugs: Synthesis, self‐assembly, and applications for cancer therapy

Dutta

et al. 2019

WIREs Nanomed Nanobiotechnol

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Block copolymer prodrugs (BCPs) have emerged as one of the most promising anticancer drug delivery strategies, which can self‐assemble into nanoparticles with optimal physicochemical properties including sizes, morphologies, surface properties, and integration of multifunction for improved in vivo applications. Moreover, the utility of stimuli‐responsive linkages to conjugate drugs onto the polymer backbones can achieve efficient and targeting drug release. Several BCP micellar delivery systems have been pushed ahead into the clinical trials, which showed great promising potentials for cancer therapy. In recent years, various novel and more efficient BCP systems have been developed for better in vivo performance. In this focus article, we focus on the recent advances of BCPs including the synthesis, self‐assembly, and applications for cancer therapy. The synthetic methods are first introduced, and the self‐assembly of BCPs for in vivo anticancer applications is discussed along the line of varying endogenous stimuli‐responsive linkages including amide or ester bonds, pH, reduction, and oxidation‐responsive linkages. Finally, conclusions along with the brief future perspectives are presented. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Nanotechnology Approaches to Biology > Nanoscale Systems in Biology

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Polymeric Micelles with Endosome Escape and Redox-Responsive Functions for Enhanced Intracellular Drug Delivery

Cited by 22 publications

References 0 publications

Designed Boron‐Rich Polymeric Nanoparticles Based on Nano‐ion Pairing for Boron Delivery

Designed Boron‐Rich Polymeric Nanoparticles Based on Nano‐ion Pairing for Boron Delivery

Boron neutron capture therapy: Current status and future perspectives

Block copolymer prodrugs: Synthesis, self‐assembly, and applications for cancer therapy

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