Polymeric micelles with aggregation-induced emission based on microbial ε-polylysine for doxorubicin delivery

Li, Yanhai; Gao, Feng; Guo, Jian Ting; Ren, Peng; Tian, Zhou; Bai, Jianan; Hua, Jie

doi:10.1016/j.eurpolymj.2019.109355

Cited by 27 publications

(33 citation statements)

References 30 publications

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“…Docetaxel (DOX) and curcumin are two main drugs normally used in cancer treatment, but their severe cytotoxicity without FIGURE 2 | The physiological and transcriptional response mechanisms of S. albulus to spontaneous acid stress in the commercial biosynthesis of EPL (Wang C. Y. et al, 2020). specificity hinders their applications (Xu et al, 2017;Li Y. et al, 2020). With excellent biocompatibility and several active sites in the side chain, EPL and its derivatives could be used as a good candidate for antitumor drug carrier system.…”

Section: Adjuvants To Antitumor Therapymentioning

confidence: 99%

“…EPL is generally believed to be safe, and it has been permitted by the Food and Drug Administration in several counties as a commercial food preservative (Cai et al, 2015 ; Buzon-Duran et al, 2019 ; Chen et al, 2019 ; Wang C. Y. et al, 2020 ). With its excellent polycationic property related to its abundant amino terminals in physiological environment and the propensity to self-assemble when modified as an amphipathic molecular (Huang et al, 2015 ; Choi et al, 2018 ; Niu et al, 2019 ; Li Y. et al, 2020 ), EPL has become a great candidate to be used in numerous fields, including antimicrobial agents, drug delivery carriers, and adjuvants in biomedical fields.…”

Section: ε -Poly-l-lysinementioning

confidence: 99%

“…Native defensive activity also stimulates the use of EPL as an antimicrobial agent. Remarkable abilities, such as edible, biocompatible, and broad (Ge et al, 2019); (B) The structure of EPL, one of the linear PLL forms; (C) Different molecular structure polylysine derivatives (Shi et al, 2015): (a) graft, (b) brush, (c) star architectures, (d) dendrimer, (e) hyperbranched, and (f) dendrigraft; (D) Self-assembled nanoparticles of PLL derivatives (Li Y. et al, 2020). antimicrobial spectrum, widen its application to fields, including food protection (Tuersuntuoheti et al, 2019), agriculture (Jiang et al, 2019;Rodrigues et al, 2020), and biomedical agents.…”

Section: Introductionmentioning

confidence: 99%

“… Structures of PLL-related polymers with different morphologies. (A) The molecular structure of PLL (Ge et al, 2019 ); (B) The structure of EPL, one of the linear PLL forms; (C) Different molecular structure polylysine derivatives (Shi et al, 2015 ): (a) graft, (b) brush, (c) star architectures, (d) dendrimer, (e) hyperbranched, and (f) dendrigraft; (D) Self-assembled nanoparticles of PLL derivatives (Li Y. et al, 2020 ). …”

Section: Introductionmentioning

confidence: 99%

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Recent Advances in Epsilon-Poly-L-Lysine and L-Lysine-Based Dendrimer Synthesis, Modification, and Biomedical Applications

Chen

Huang

et al. 2021

Front. Chem.

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With the advantages in biocompatibility, antimicrobial ability, and comparative facile synthesis technology, poly-L-lysine (PLL) has received considerable attention in recent years. Different arrangement forms and structures of the backbone endow lysine-based polymers with versatile applications, especially for ε-poly-L-lysine (EPL) and lysine-based dendrimer (LBD) compounds. This review summarized the advanced development of the synthesis and modification strategies of EPL and LBD, focus on the modification of bio-synthesis and artificial synthesis, respectively. Meanwhile, biomedical fields, where EPL and LBD are mainly utilized, such as agents, adjuvants, or carriers to anti-pathogen or used in tumor or gene therapies, are also introduced. With the deeper of knowledge of pharmacodynamics and pharmacokinetics of the drug system, the design and synthesis of these drugs can be further optimized. Furthermore, the performances of combination with other advanced methodologies and technologies demonstrated that challenges, such as scale production and high expenses, will not hinder the prospective future of lysine-based polymers.

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Section: Adjuvants To Antitumor Therapymentioning

confidence: 99%

Section: ε -Poly-l-lysinementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Recent Advances in Epsilon-Poly-L-Lysine and L-Lysine-Based Dendrimer Synthesis, Modification, and Biomedical Applications

Chen

Huang

et al. 2021

Front. Chem.

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“…To date, a significant amount of research has been conducted with the purpose of reducing the toxic effect of doxorubicin on healthy cells by creating means of its targeted delivery. Various types of different systems for the targeted delivery have been considered, in particular, based on liposomes [215][216][217][218][219][220][221][222] (similar forms have already found application in medical practice [223][224][225][226][227]); proteins [228][229][230][231][232][233]; polymers [234][235][236][237][238][239][240][241][242][243]; fullerenes and CNT [35,[244][245][246][247][248][249][250][251]; metal and oxide nanoparticles [52,76] (gold [250][251][252][253][254][255]...…”

Section: Association Of Poms With Bioactive Substances and Polymersmentioning

confidence: 99%

Physicochemical and biochemical properties of the Keplerate-type nanocluster polyoxomolybdates as promising components for biomedical use

Ostroushko¹,

Grzhegorzhevskii²,

Medvedeva³

et al. 2021

Nanosystems: Phys. Chem. Math.

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The paper discusses the results of a research on physicochemical and biochemical properties of the Keplerate-type molybdenum-based nanocluster polyoxometalates (POMs), which show promise in the field of biomedicine as a means of targeted drug delivery, including the transport to immune privileged organs. POMs can be considered as components of releasing systems, including the long-acting ones with feedback (for controlling the drug active component release rate). POMs are promising drugs for the treatment of anemia. Also, the paper deals with the results of studies of POM effect on living systems at the molecular and cellular levels, at that of individual organs, and on the organism as a whole. The mechanism and kinetics of POM destruction and possibilities of stabilization, the oscillatory phenomena manifestation, the formation of POM conjugates with bioactive substances which can be released during the destruction of POM, with polymer components, and with indicator fluorescent dyes, as well as forecasts for further research, are considered.

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Strategies for Targeted Delivery via Structurally Variant Polymeric Nanocarriers

Chakraborty,

Meher,

Dash

et al. 2023

ChemistrySelect

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The last decade has seen a meteoric rise in studies investigating polymeric aggregates as nanocarriers. When it comes to morphology, size, functionality, and immunostability, polymeric nanocarriers (PNCs) are unparalleled. With characteristics such as large surface area to volume ratio, amphiphilic nano‐environment, non‐toxic components, chemically modifiable composition, external surface alteration potential, uniform particle size, and stimuli‐dependent self‐assembly, PNCs have emerged as strong candidates for therapeutic applications. The article reviews the latest research on different challenges and strategies for targeted drug delivery and shall serve as guide to the researchers in designing site‐specific nanocarriers for application in future. The review systematically discusses the fundamental structural variation of the nanocarriers with emphasis on the influence of chemical alterations and the resulting effects on functionality; addresses the difficulties encountered with modes of administration; target selectivity and stimulus response.

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Polymeric micelles with aggregation-induced emission based on microbial ε-polylysine for doxorubicin delivery

Cited by 27 publications

References 30 publications

Recent Advances in Epsilon-Poly-L-Lysine and L-Lysine-Based Dendrimer Synthesis, Modification, and Biomedical Applications

Recent Advances in Epsilon-Poly-L-Lysine and L-Lysine-Based Dendrimer Synthesis, Modification, and Biomedical Applications

Physicochemical and biochemical properties of the Keplerate-type nanocluster polyoxomolybdates as promising components for biomedical use

Strategies for Targeted Delivery via Structurally Variant Polymeric Nanocarriers

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