Polymeric micelles for theranostic uses

Ray, Somasree; Seth, Shalmoli; Bhattacharyya, Uttam Kumar; Sen, Malini

doi:10.1016/b978-0-323-89953-6.00007-6

Cited by 2 publications

(3 citation statements)

References 26 publications

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“…As a result, hydrophobic medicines can nevertheless be stable in water. Micelles can also be eliminated by renal filtration and are less harmful [ 226 ]. Drugs that are insoluble in water can be stored and derived from micelles in their hydrophobic core [ 226 ].…”

Section: Advantages and Drawbacks Of Polymeric Micellar Systemsmentioning

confidence: 99%

“…Micelles can also be eliminated by renal filtration and are less harmful [ 226 ]. Drugs that are insoluble in water can be stored and derived from micelles in their hydrophobic core [ 226 ]. The best micelles for delivering hydrophobic medications were those with a hydrophilic corona to stabilize and shield the hydrophobic medication.…”

Section: Advantages and Drawbacks Of Polymeric Micellar Systemsmentioning

confidence: 99%

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Polymeric Micellar Systems—A Special Emphasis on “Smart” Drug Delivery

Neguț

Biţă

2023

Pharmaceutics

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Concurrent developments in anticancer nanotechnological treatments have been observed as the burden of cancer increases every year. The 21st century has seen a transformation in the study of medicine thanks to the advancement in the field of material science and nanomedicine. Improved drug delivery systems with proven efficacy and fewer side effects have been made possible. Nanoformulations with varied functions are being created using lipids, polymers, and inorganic and peptide-based nanomedicines. Therefore, thorough knowledge of these intelligent nanomedicines is crucial for developing very promising drug delivery systems. Polymeric micelles are often simple to make and have high solubilization characteristics; as a result, they seem to be a promising alternative to other nanosystems. Even though recent studies have provided an overview of polymeric micelles, here we included a discussion on the “intelligent” drug delivery from these systems. We also summarized the state-of-the-art and the most recent developments of polymeric micellar systems with respect to cancer treatments. Additionally, we gave significant attention to the clinical translation potential of polymeric micellar systems in the treatment of various cancers.

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Section: Advantages and Drawbacks Of Polymeric Micellar Systemsmentioning

confidence: 99%

Section: Advantages and Drawbacks Of Polymeric Micellar Systemsmentioning

confidence: 99%

Polymeric Micellar Systems—A Special Emphasis on “Smart” Drug Delivery

Neguț

Biţă

2023

Pharmaceutics

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“…Although they do not possess an internal aqueous phase, cochleates can incorporate a variety of hydrophilic and hydrophobic molecules. In 1999, nanocochleates were introduced as molecules with sizes between 50 and 100 nm, which makes them desirable for use in applications routes [93,94]. More attention is being given to them due to their advantages such as improved stability, efficient incorporation of guest molecules, slow drug release, protection, and enhanced bioavailability of encapsulated pharmaceuticals [95,96].…”

Section: Nanocochleatesmentioning

confidence: 99%

Fisetin—In Search of Better Bioavailability—From Macro to Nano Modifications: A Review

Szymczak,

Cielecka-Piontek

2023

IJMS

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As secondary plant metabolites, polyphenols are abundant in fruits and vegetables. They are in high demand because of their many health benefits. However, their low bioavailability makes them complex compounds to use for therapeutic purposes. Due to the limited solubility of phytocompounds, dietary supplements made from them may only be partially effective. Such molecules include fisetin, found in strawberries, and have shown great promise in treating Alzheimer’s disease and cancer. Unfortunately, because of their limited water solubility, low absorption, and poor bioavailability, the assistance of nanotechnology is required to allow them to fulfil their potential fully. Here, we provide evidence that nanodelivery methods and structure modifications can improve fisetin bioavailability, which is linked to improvements in therapeutic efficacy. An open question remains as to which nanocarrier should be chosen to meet the abovementioned requirements and be able to enhance fisetin’s therapeutic potential to treat a particular disease.

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Polymeric micelles for theranostic uses

Cited by 2 publications

References 26 publications

Polymeric Micellar Systems—A Special Emphasis on “Smart” Drug Delivery

Polymeric Micellar Systems—A Special Emphasis on “Smart” Drug Delivery

Fisetin—In Search of Better Bioavailability—From Macro to Nano Modifications: A Review

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