Polymeric micelles for drug delivery

Aliabadi, Hamidreza Montazeri; Lavasanifar, Afsaneh

doi:10.1517/17425247.3.1.139

Cited by 394 publications

(205 citation statements)

References 166 publications

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“…18 Therefore, most of the established techniques for micelle formation are not suitable for scaling-up from laboratory level to industrial production and suffer from low reproducibility and poor control over the micelle size. 19 Thus, there is a strong need for improvements in micelle preparation techniques.…”

Section: Introductionmentioning

confidence: 99%

pH-Sensitive Micelles for Targeted Drug Delivery Prepared Using a Novel Membrane Contactor Method

Laouini

Koutroumanis

Charcosset

et al. 2013

ACS Appl. Mater. Interfaces

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A novel membrane contactor method was used to produce size-controlled poly(ethylene glycol)-b-polycaprolactone (PEG-PCL) copolymer micelles composed of diblock copolymers with different average molecular weights, M n (9200 or 10 400 Da) and hydrophilic fractions, f (0.67 or 0.59). By injecting 570 L m −2 h −1 of the organic phase (a 1 mg mL −1 solution of PEG-PCL in tetrahydrofuran) through a microengineered nickel membrane with a hexagonal pore array and 200 μm pore spacing into deionized water agitated at 700 rpm, the micelle size linearly increased from 92 nm for a 5-μm pore size to 165 nm for a 40-μm pore size. The micelle size was finely tuned by the agitation rate, transmembrane flux and aqueous to organic phase ratio. An encapsulation efficiency of 89% and a drug loading of ∼75% (w/w) were achieved when a hydrophobic drug (vitamin E) was entrapped within the micelles, as determined by ultracentrifugation method. The drug-loaded micelles had a mean size of 146 ± 7 nm, a polydispersity index of 0.09 ± 0.01, and a ζ potential of −19.5 ± 0.2 mV. When drug-loaded micelles where stored for 50 h, a pH sensitive drug release was achieved and a maximum amount of vitamin E (23%) was released at the pH of 1.9. When a pH-sensitive hydrazone bond was incorporated between PEG and PCL blocks, no significant change in micelle size was observed at the same micellization conditions.

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Section: Introductionmentioning

confidence: 99%

pH-Sensitive Micelles for Targeted Drug Delivery Prepared Using a Novel Membrane Contactor Method

Laouini

Koutroumanis

Charcosset

et al. 2013

ACS Appl. Mater. Interfaces

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“…Polymeric micelles are another type of nanomaterial that have attracted considerable attention as carriers for drug delivery (Kataoka et al 2001;Kabanov and Alakhov 2002;Kwon 2003;Allen and Cullis 2004;Torchilin 2004;Aliabadi and Lavasanifar 2006) and diagnostic imaging agents (Torchilin 2002). These micelles form spontaneously in aqueous solutions of amphiphilic block copolymers and have core-shell architecture.…”

Section: Nanomaterials For Drug Delivery Across the Blood-brain Barriermentioning

confidence: 99%

Novel Nanomaterials for Clinical Neuroscience

Gilmore

Xiang

Quan

et al. 2008

J Neuroimmune Pharmacol

205

123

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Neurodegenerative disorders including Alzheimer's and Parkinson's diseases, amyotrophic lateral sclerosis, and stroke are rapidly increasing as population ages. The field of nanomedicine is rapidly expanding and promises revolutionary advances to the diagnosis and treatment of devastating human diseases. This paper provides an overview of novel nanomaterials that have potential to improve diagnosis and therapy of neurodegenerative disorders. Examples include liposomes, nanoparticles, polymeric micelles, block ionomer complexes, nanogels, and dendrimers that have been tested clinically or in experimental models for delivery of drugs, genes, and imaging agents. More recently discovered nanotubes and nanofibers are evaluated as promising scaffolds for neuroregeneration. Novel experimental neuroprotective strategies also include nanomaterials, such as fullerenes, which have antioxidant properties to eliminate reactive oxygen species in the brain to mitigate oxidative stress. Novel technologies to enable these materials to cross the blood brain barrier will allow efficient systemic delivery of therapeutic and diagnostic agents to the brain. Furthermore, by combining such nanomaterials with cell-based delivery strategies, the outcomes of neurodegenerative disorders can be greatly improved.

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“…Polymeric micelles ("micellar nanocontainers") have also been developed as carriers of drugs [125,[208][209][210][211][212] and diagnostic imaging agents [213]. They form spontaneously in aqueous solutions of amphiphilic block copolymers and have a core-shell architecture with a core of hydrophobic polymer blocks (e.g., poly(propylene glycol) (PPG), poly (D,L-lactide), poly (caprolactone), etc.)…”

Section: Polymeric Micellesmentioning

confidence: 99%

Nanomedicine in the diagnosis and therapy of neurodegenerative disorders

Kabanov

Gendelman

2007

Progress in Polymer Science

234

138

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Neurodegenerative and infectious disorders including Alzheimer's and Parkinson's diseases, amyotrophic lateral sclerosis, and stroke are rapidly increasing as population's age. Alzheimer's disease alone currently affects 4.5 million Americans, and more than $100 billion is spent per year on medical and institutional care for affected people. Such numbers will double in the ensuing decades. Currently disease diagnosis for all disorders is made, in large measure, on clinical grounds as laboratory and neuroimaging tests confirm what is seen by more routine examination. Achieving early diagnosis would enable improved disease outcomes. Drugs, vaccines or regenerative proteins present "real" possibilities for positively affecting disease outcomes, but are limited in that their entry into the brain is commonly restricted across the blood-brain barrier. This review highlights how these obstacles can be overcome by polymer science and nanotechnology. Such approaches may improve diagnostic and therapeutic outcomes. New developments in polymer science coupled with cell-based delivery strategies support the notion that diseases that now have limited therapeutic options can show improved outcomes by advances in nanomedicine.

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Polymeric micelles for drug delivery

Cited by 394 publications

References 166 publications

pH-Sensitive Micelles for Targeted Drug Delivery Prepared Using a Novel Membrane Contactor Method

pH-Sensitive Micelles for Targeted Drug Delivery Prepared Using a Novel Membrane Contactor Method

Novel Nanomaterials for Clinical Neuroscience

Nanomedicine in the diagnosis and therapy of neurodegenerative disorders

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