Polymeric Micelles and their Properties

Wakaskar, Rajesh R

doi:10.4172/2157-7439.1000433

Cited by 35 publications

(10 citation statements)

References 10 publications

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“…Polymeric micelles are useful for the delivery of hydrophobic and hydrophilic drugs to the target site. Their good stability, slow dissociation extend their circulation times, and their specific accumulation in the tumor tissues [ 229 ]. Small hydrophobic drugs are solubilized in the inner hydrophobic core of micelles, and their outer hydrophilic shell protects the drug from scavengers by the mononuclear phagocytic system [ 230 , 231 ].…”

Section: Polymeric Micellesmentioning

confidence: 99%

“…The factor mentioned above is attributed to a shift from equilibrium to a unimer state and binding of the proteins to the unimeric components [ 231 ]. The protein binding can result in a burst release effect of the encapsulated drugs into the bloodstream, thereby nullifying the unique properties of micelles such as high drug loading, targeting capability, and prolonged blood circulation [ 225 , 229 ]. It can result in drug biodistribution that is favourable and toxicity with therapeutic outcomes similar to the free drugs [ 232 ].…”

Section: Polymeric Micellesmentioning

confidence: 99%

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The Therapeutic Efficacy of Dendrimer and Micelle Formulations for Breast Cancer Treatment

Alven

Aderibigbe

2020

Pharmaceutics

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Breast cancer is among the most common types of cancer in women and it is the cause of a high rate of mortality globally. The use of anticancer drugs is the standard treatment approach used for this type of cancer. However, most of these drugs are limited by multi-drug resistance, drug toxicity, poor drug bioavailability, low water solubility, poor pharmacokinetics, etc. To overcome multi-drug resistance, combinations of two or more anticancer drugs are used. However, the combination of two or more anticancer drugs produce toxic side effects. Micelles and dendrimers are promising drug delivery systems that can overcome the limitations associated with the currently used anticancer drugs. They have the capability to overcome drug resistance, reduce drug toxicity, improve the drug solubility and bioavailability. Different classes of anticancer drugs have been loaded into micelles and dendrimers, resulting in targeted drug delivery, sustained drug release mechanism, increased cellular uptake, reduced toxic side effects of the loaded drugs with enhanced anticancer activity in vitro and in vivo. This review article reports the biological outcomes of dendrimers and micelles loaded with different known anticancer agents on breast cancer in vitro and in vivo.

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Section: Polymeric Micellesmentioning

confidence: 99%

Section: Polymeric Micellesmentioning

confidence: 99%

The Therapeutic Efficacy of Dendrimer and Micelle Formulations for Breast Cancer Treatment

Alven

Aderibigbe

2020

Pharmaceutics

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“…These characteristics confer desirable attributes to these polymeric micelles and they can be conceptually developed as a robust nanocarrier. These polymeric micelles are formed above certain concentrations of the polymer, also known as critical micellar concentration (CMC) and above a certain temperature, which is also known as the critical micellar temperature (CMT) [17]. A suitable example of this polymeric micelle, under clinical evaluation, is the NK911.…”

Section: Polymeric Micellesmentioning

confidence: 99%

Cancer Therapy with the Aid of Nanotherapeutics

Wakaskar¹

2017

J Biomol Res Ther

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“…This is the basis of understanding the correlation between structure and dynamics in soft matter physics [1][2]. These studies include various fields of research, such as macrophase and microphase separation [3][4][5], gelation [6][7][8], crystallization [9,10] and association phenomena [11][12][13]. The progress in this area is closely related to the advances in the synthesis of well-defined macromolecular structures having the maximum control over the molecular characteristics and the architecture [14][15][16][17][18][19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Complexes of end-functionalized polystyrenes carrying amine end-group with transition metals: association effects in organic solvents

2019

Biointerface Res Appl Chem

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Linear end-functionalized polystyrenes of different molecular weights bearing amino end-group (NPS) were synthesized by anionic polymerization high vacuum techniques. The polymers were exposed to copper and iron salts (CuCl2.2H2O and FeCl3.6H2O) to form complexes with specific metal/amino molar ratios. The thermal stability of these complexes was studied by Thermogravimetric Analysis (TGA) and Differential Thermogravimetry (DTG), whereas their solution behavior was studied by Low Angle Laser Light Scattering (LALLS), Dynamic Light Scattering (DLS) and dilute solution Viscometry. Extended aggregation phenomena of these complexes were observed in organic solvents. The association behavior was influenced by the molecular weight of the polymer chain, the metal/amine group molar ratio, the chemical nature of the metal and the polarity of the solvent. A complex situation was revealed by DLS showing the existence of equilibrium between aggregates and clusters. Under the influence of shear forces applied in the capillary tube of the viscometer the clusters are disrupted.

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Polymeric Micelles and their Properties

Cited by 35 publications

References 10 publications

The Therapeutic Efficacy of Dendrimer and Micelle Formulations for Breast Cancer Treatment

The Therapeutic Efficacy of Dendrimer and Micelle Formulations for Breast Cancer Treatment

Cancer Therapy with the Aid of Nanotherapeutics

Complexes of end-functionalized polystyrenes carrying amine end-group with transition metals: association effects in organic solvents

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