Polymeric micelles and nanomedicines: Shaping the future of next generation therapeutic strategies for infectious diseases

Toscanini, María Agustina; Limeres, María J.; Garrido, Agustín Videla; Cagel, Maximiliano; Bernabeu, Ezequiel; Morettón, Marcela A.; Cuestas, María Luján

doi:10.1016/j.jddst.2021.102927

Cited by 12 publications

(5 citation statements)

References 161 publications

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“…Micelles are composed of an inner lipophilic core, involved in drug loading and release, and an external hydrophilic shell, responsible for micelles interaction with body targets. These nanosystems, in addition to a relatively easy preparation, sterilization method and high scale-up feasibility, showed good solubilization properties and efficient cellular internalization [13][14][15]. In case of ocular delivery, micelles have demonstrated the ability to enhance drug transport to the anterior eye segment [16][17][18] thanks to an improved solubility of drugs, higher penetration capacity (due to their nanometric size) and prolonged drug release [19][20][21].…”

mentioning

confidence: 99%

Cyclosporine-loaded micelles for ocular delivery: Investigating the penetration mechanisms

Ghezzi

Ferraboschi

Delledonne

et al. 2022

Journal of Controlled Release

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mentioning

confidence: 99%

Cyclosporine-loaded micelles for ocular delivery: Investigating the penetration mechanisms

Ghezzi

Ferraboschi

Delledonne

et al. 2022

Journal of Controlled Release

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“…The thin-film hydration process involves dissolving copolymers in an organic solvent, evaporating the solvent to create a thin polymer film, adding a water phase to hydrate the film, and stirring to produce the micelle. Additionally, the solvent evaporation approach implies the dissolution of the copolymer in an organic solvent, adding water to the mixture to create the micelle, and then evaporating the solvent [ 29 ].…”

Section: General Issues and Status Quo Of Polymeric Micellesmentioning

confidence: 99%

Polymeric Micellar Systems—A Special Emphasis on “Smart” Drug Delivery

Neguț

Biţă

2023

Pharmaceutics

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Concurrent developments in anticancer nanotechnological treatments have been observed as the burden of cancer increases every year. The 21st century has seen a transformation in the study of medicine thanks to the advancement in the field of material science and nanomedicine. Improved drug delivery systems with proven efficacy and fewer side effects have been made possible. Nanoformulations with varied functions are being created using lipids, polymers, and inorganic and peptide-based nanomedicines. Therefore, thorough knowledge of these intelligent nanomedicines is crucial for developing very promising drug delivery systems. Polymeric micelles are often simple to make and have high solubilization characteristics; as a result, they seem to be a promising alternative to other nanosystems. Even though recent studies have provided an overview of polymeric micelles, here we included a discussion on the “intelligent” drug delivery from these systems. We also summarized the state-of-the-art and the most recent developments of polymeric micellar systems with respect to cancer treatments. Additionally, we gave significant attention to the clinical translation potential of polymeric micellar systems in the treatment of various cancers.

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“…60 Beberapa produk yang saat ini menjalani uji klinik, semuanya untuk terapi kanker dan dengan rute pemberian intravena. 61 Saat ini, misel polimer GENEXOL-PM, misel dengan kopolimer PEG-PLA dengan bahan aktif paclitaxel telah disetujui untuk terapi kanker payudara metastasis dan non-small cell lung cancer di Korea Selatan, Bulgaria dan Hongaria, dan menjadi satu-satunya formulasi misel yang telah mencapai pasar. 62 Dekade ini sudah cukup banyak riset misel polimer yang diarahkan untuk penggunaan oral.…”

Section: Pharmaceuticalunclassified

Sistem Penghantaran Obat Dengan Misel Polimer

Milala

2022

MEDICINUS

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Saat ini dapat dikatakan sebagai era nanoteknologi, karena teknologi ini digunakan hampir di segala bidang, termasuk bidang tekonologi farmasi yang mulai gencar mengembangkan sediaan farmasi dengan dengan sistem nano. Salah satu sistem nano tersebut berupa misel polimer, yang umumnya memiliki ukuran partikel di bawah 100 nm. Berdasarkan hasil riset, misel polimer terbukti mampu meningkatkan kelarutan serta bioavailabilitas obat yang bersifat hidrofobik. Terdapat beberapa metode pembuatan misel polimer yang masing-masing memiliki keunggulan dan kekurangan. Evaluasi yang dilakukan untuk mengkarakterisasi misel polimer di antaranya adalah penentuan critical micelle concentration (CMC), ukuran partikel, karakteristik permukaan, stabilitas, dan uji pelepasan. Walaupun sebagian besar riset misel polimer diaplikasikan dalam bidang onkologi dengan rute pemberian intravena, namun saat ini semakin banyak peneliti yang mengembangkan riset pengembangan obat untuk rute pemberian per oral. Dengan semakin banyak riset terkait penerapan teknologi misel polimer untuk obat per oral, diharapkan dapat mendorong uji klinik seperti yang dilakukan pada obat-obatan intravena.

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Polymeric micelles and nanomedicines: Shaping the future of next generation therapeutic strategies for infectious diseases

Cited by 12 publications

References 161 publications

Cyclosporine-loaded micelles for ocular delivery: Investigating the penetration mechanisms

Cyclosporine-loaded micelles for ocular delivery: Investigating the penetration mechanisms

Polymeric Micellar Systems—A Special Emphasis on “Smart” Drug Delivery

Sistem Penghantaran Obat Dengan Misel Polimer

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