Polymeric materials in treatment of wounds

Legonkova, O.A.; Belova, M. S.

doi:10.1134/s1995421215030077

Cited by 2 publications

(2 citation statements)

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“…Wound dressings have to be multifunctional: to facilitate debridement, stimulate the regeneration of healthy tissue, prevent bacterial contamination, and at the same time maintain a moist environment and prevent the formation of contractures 15,18. We used AZL-CMC Gel, which is a synthetic mediator, with an underlying gelatinous substance (CMC 2%).…”

Section: Discussionmentioning

confidence: 99%

“…In addition to growth factors, stem cells, nanoparticles, platelet-rich plasma and other wound treatments,14 wound healing treatment requires the use of a wide range of dressing materials: films, foams, hydrogels, hydrocolloids, and impregnated coverings containing antimicrobial agents, enzymes, and various biologically active substances 15,16. Hydrogels take advantage of a hydrophilic material that absorbs a certain amount of exudate but keeps a moist environment 17…”

Section: Introductionmentioning

confidence: 99%

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<p>Effects of Azelnidipine-Carboxymethylcellulose Gel on Healing of Full-Thickness Skin Wounds in Streptozotocin Induced Diabetic Rats</p>

Karami

Mansournia

Bagherian

et al. 2019

VMRR

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ObjectiveTo evaluate the effects of azelnidipine-carboxyl methyl cellulose (AZL-CMC) gel and carboxyl methyl cellulose 2% gel (CMC) on the healing of full-thickness skin wounds of diabetic rats.MethodsFifteen Sprague Dawley male rats were studied. The rats were divided into three groups: AZL-CMC gel-treated, CMC 2% gel-treated, and control group. Wounds were assessed by wound area measurement every 3 days and histopathology samples were collected at 4, 7 and 12 days post wounding to evaluate the healing process using stereological study. Mann–Whitney U-test repeated measurement and non-parametric one-way analysis of variance (ANOVA) were used to analyze the data using SPSS, version 18.ResultsNumerical density of the fibroblasts of the AZL-CMC gel treated group was 59.17±2.69 (×104/mm3) and higher than the control 22.64±1.34 (×104/mm3) and CMC 2%-treated groups 40.80±5.27 (×104/mm3), respectively, P<0.001. The volume density of the collagen bundles and LV of the vessels were 83.1±4.46 and 42.16±5.78, respectively, in the AZL-CMC treated group, and higher compared to the control (53.96±5.07, 9.9±2.49) and the CMC 2%-treated (65.88±2.13, 18.1±2.20) groups (P <0.001).ConclusionThe healing of AZL-CMC gel-treated wound was better than the control wounds, grossly. Wound healing processes and wound closure in the intervention group began sooner and was completed more quickly. The quantitative and qualitative parameters showed the significant wound healing effect of the AZL-CMC gel-treated group.

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Section: Discussionmentioning

confidence: 99%