Polymeric magnetic nanoparticles: a multitargeting approach for brain tumour therapy and imaging

Joshi, Bhavana; Joshi, Abhijeet

doi:10.1007/s13346-021-01063-9

Cited by 12 publications

(11 citation statements)

References 93 publications

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“…Magnetic nanomaterials with tunable structure/morphologies, high imaging abilities, and multivalent metal combination properties have been widely applied in highdensity magnetic storage, hard/soft magnetic nanocomposites, sensors, and drug carriers in biomedical technology. [38][39][40][41][42] Among them, magnetically ferromagnetic alloys with the synergistic interaction between transition metals (Tm) and rare earth (Re) metals have been highlighted in the field of catalysis due to the unique electronic structure in the 4f shell of Re metals. [43][44][45] As one of the Re-Tm nanoparticles, Sm/Co alloys with variable elements (Sm 3+ ; Co 3+ , Co 2+ , and Co 0 ) have been applied in the field of electrocatalysis and can be expected to be used as nanozymes in the field of tumor catalysis therapeutics.…”

Section: Introductionmentioning

confidence: 99%

Sm/Co‐Doped Silica‐Based Nanozymes Reprogram Tumor Microenvironment for ATP‐Inhibited Tumor Therapy

Ding

Chang

et al. 2023

Adv Healthcare Materials

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Current applications of multifunctional nanozymes for reprogramming the redox homeostasis of the tumor microenvironment (TME) have been severely confronted with low catalytic activity and the ambiguity of active sites of nanozymes, as well as the stress resistance from the rigorous physical environment of tumor cells. Herein, the Sm/Co‐doped mesoporous silica with 3PO‐loaded nanozymes (denoted as mSC‐3PO) are rationally constructed for simultaneously inhibiting energy production by adenosine triphosphate (ATP) inhibitor 3PO and reprogramming TME by multiactivities of nanozymes with photothermal effect assist, i.e., enhanced peroxidase‐like, catalase‐like activity, and glutathione peroxidase‐like activities, facilitating reactive oxygen species (ROS) generation, promoting oxygen content, and restraining the over‐expressed glutathione. Through the optimal regulation of nanometric size and doping ratio, the fabricated superparamagnetic mSC‐3PO enables the excellent exposure of active sites and avoids agglomeration owing to the large specific surface and mesoporous structure, thus providing adequate Sm/Co‐doped active sites and enough spatial distribution. The constructed Sm/Co centers both participate in the simulated biological enzyme reactions and carry out the double‐center catalytic process (Sm3+and Co3+/Co2+). Significantly, as the inhibitor of glycolysis, 3PO can reduce the ATP flow by cutting down the energy transform, thereby inhibiting tumor angiogenesis and assisting ROS to promote the early withering of tumor cells. In addition, the considerable near‐infrared (NIR) light absorption of mSC‐3PO can adapt to NIR excitable photothermal treatment therapy and photoexcitation‐promoted enzymatic reactions. Taken together, this work presents a typical therapeutic paradigm of multifunctional nanozymes that simultaneously reprograms TME and promotes tumor cell apoptosis with photothermal assistance.

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Section: Introductionmentioning

confidence: 99%

Sm/Co‐Doped Silica‐Based Nanozymes Reprogram Tumor Microenvironment for ATP‐Inhibited Tumor Therapy

Ding

Chang

et al. 2023

Adv Healthcare Materials

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“…This enables the synthesis of nanoparticles in multiple steps, while an ultrasonic atomizer led the development of drug-loaded polymer−magnetic nanoparticles allowing one to formulate nanoparticles in a single step. 6 The current research describes an ultrasonic atomization-led development of multifunctional anticancer nanohybrid theranostic particles having therapeutic and diagnostic features. The theranostic ultrasmall nanohybrid particles so developed are characterized using fluorescence spectroscopy, transmission electron microscopy (TEM), encapsulation efficiency, in vitro drug release, and in vivo tumor reduction capability using Swiss Albino mice.…”

Section: Introductionmentioning

confidence: 99%

“…Ultrasmall magnetic nanoparticles of 5–20 nm sizes have shown to have better therapeutic efficiency due to their deep penetration in the tumor microenvironment and less toxicity as compared to larger sized nanoparticles, and they also proved to be a promising tool for magnetic hyperthermia which ultimately increases the therapeutic efficiency. , From the various methods for synthesizing these ultrasmall polymeric magnetic nanoparticles, the most widely accepted is the double emulsification method using a sonication technique. This enables the synthesis of nanoparticles in multiple steps, while an ultrasonic atomizer led the development of drug-loaded polymer–magnetic nanoparticles allowing one to formulate nanoparticles in a single step …”

Section: Introductionmentioning

confidence: 99%

“…They can also be coimmobilized into polymeric systems which are loaded with chemotherapeutic drugs. Such a coimmobilized system with multiple roles and functionalities will reduce the overall cost of diagnosis and therapy. − Drugs like cisplatin, doxorubicin, and tamoxifen have been used for cancer therapy for many decades. , In order to improve the efficacy of these established drugs, they may be immobilized in carriers which have stimuli-responsive behavior . An acidic pH of the tumor tissue microenvironment can favour the stimuli-responsive drug release due to an increase in hydrolysis and degradation of polymer chains .…”

Section: Introductionmentioning

confidence: 99%

“…Magnetic resonance imaging capabilities can help in imaging the tumor. Magneto-polymeric nanohybrid particles can be used for active targeting …”

Section: Introductionmentioning

confidence: 99%

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Multifunctional Ultrasmall Theranostic Nanohybrids Developed by Ultrasonic Atomizer for Drug Delivery and Magnetic Resonance Imaging

Joshi

Shankar

Vishwakarma

et al. 2023

ACS Appl. Bio Mater.

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Theranostic nanoparticulate systems (TNPs) have shown potential in addressing problems related to spatial localization and temporally controlled release of drugs with the capabilities of real-time imaging to evaluate the progress of therapy. The current study reports the ultrasonic atomization-led synthesis of in vitro and in vivo evaluations of ultrasmall chitosan-based theranostic nanohybrid formulations with encapsulated doxorubicin (DOX) and iron-oxide magnetic nanoparticles. The nanohybrid particles are characterized using transmission electron microscopy, powder X-ray diffraction, FTIR, DOX encapsulation efficiency, in vitro release, cellular uptake, and toxicity. These formulations were also tested for the capability of in vivo tumor reduction and simultaneous magnetic resonance imaging using Swiss albino mice. Ultrasonic atomizer-led synthesis resulted in chitosan–magnetic nanohybrids (CMNPs) having sizes of 15 ± 3 nm which comprise MNP of 10 ± 3 nm. The encapsulation of DOX in CMNP was around 25%, resulting in an 80% sustained release over 10 days at pH 5 and 7. CMNP was also found to be an efficient DOX delivery vehicle tested on cancer cells (HeLa). The CMNPs were able to reduce the tumor volume by 60% in 15 days. The inherent magnetic property and nanoscale size of CMNPs also provided for enhanced contrast efficiency in magnetic resonance imaging of tumors. Thus, such multifunctional theranostic nanoparticles can be an efficient tool for targeted diagnostic and therapeutic success.

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The High Potential of ε‐Poly‐l‐Lysine for the Development of Antimicrobial Biomaterials

Lebaudy,

Guilbaud-Chéreau,

Frisch

et al. 2023

Advanced NanoBiomed Research

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ε‐poly‐l‐lysine (ε‐PLL) is a natural polypeptide/polycation originating from bacteria. Thanks to its antifungal and antibacterial properties, it is the subject of extensive research in the food and medical industries. ε‐PLL is also used to develop biomaterials in a broad range of applications, such as drug delivery, wound healing, or antimicrobial coatings. Indeed, loading ε‐PLL inside nanoparticles, functionalizing implant surfaces with ε‐PLL, or developing hydrogels based on reactions between ε‐PLL and other polymers can improve the materials properties, leading to biocompatible, antibacterial, and antifungal systems. These characteristics are necessary not only for the development of biomaterials, for their integrity in a biological environment, but also for improving the performances of medical devices. Moreover, ε‐PLL can be used as an alternative to antibiotics as its mechanism of action reduces the bacterial resistance risk compared with antibiotics. Finally, “smart” systems using ε‐PLL may be developed, with controllable material degradation or drug delivery via pH or temperature variations. This review sought to gather the latest research on the development of antimicrobial biomaterials based on the ε‐PLL polypeptide.

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Polymeric magnetic nanoparticles: a multitargeting approach for brain tumour therapy and imaging

Cited by 12 publications

References 93 publications

Sm/Co‐Doped Silica‐Based Nanozymes Reprogram Tumor Microenvironment for ATP‐Inhibited Tumor Therapy

Sm/Co‐Doped Silica‐Based Nanozymes Reprogram Tumor Microenvironment for ATP‐Inhibited Tumor Therapy

Multifunctional Ultrasmall Theranostic Nanohybrids Developed by Ultrasonic Atomizer for Drug Delivery and Magnetic Resonance Imaging

The High Potential of ε‐Poly‐l‐Lysine for the Development of Antimicrobial Biomaterials

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