Polymeric grape seed tannins prevent plasma cholesterol changes in high-cholesterol-fed rats

Tebib, Katia; Bitri, Lotfi; Besançon, P.; Rouanet, Jean-Max

doi:10.1016/0308-8146(94)90012-4

Cited by 78 publications

(52 citation statements)

References 23 publications

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“…In our study, as well as in previous feeding experiments with rats [20], it was observed that addition of cholesterol, fat component and cholic acid to normal diet increase plasma cholesterol concentration, i.e. enhance the hyperlipidemic effect.…”

Section: Biochemical Analysis 321 Plasma Lipid Levels and Transaminsupporting

confidence: 81%

Antihyperlipidemic, antioxidant and weightlowering effects of “Vitalplant”

et al. 2015

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BACKGROUND: “VITALPLANT” medicinal plant mixture, aimed at body weight regulation and metabolism enhancement was formulated in order to be incorporated as an ingredient in functional food formulations on the basis of known biological activity of the alder buckthorn bark, peppermint, caraway and parsley. METHODOLOGY: The body weight-lowering potential, hypolipidemic effects and antioxidant activity of “Vitalplant” mixture were examined on five groups of male Wistar rats on different food regimes for 14 weeks. RESULTS: “Vitalplant” mixture supplementation caused an increase in food intake, but induced a decrease in body weight gain. The lipid status and atherogenic index (AI) were significantly improved in “Vitalplant” mixture supplemented hyperlipidemic (HF) groups in comparison to HF group. “Vitalplant” mixture was able to influence the activity of antioxidant enzymes and to protect erythrocytes of the rats fed the HF diet from oxidative damage, which was indicated by significantly lower malondialdehyde (MDA) levels in “Vitalplant”- HF groups in comparison to the HF group. CONCLUSION: “Vitalplant” mixture seemed to be beneficial for the reduction of body weight and improvement of antioxidant status of the erythrocytes, and its antihyperlipidemic property was highly active for enhancing the profile of plasma lipids in rats.

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Section: Biochemical Analysis 321 Plasma Lipid Levels and Transaminsupporting

confidence: 81%

Antihyperlipidemic, antioxidant and weightlowering effects of “Vitalplant”

et al. 2015

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“…Polyphenolic compounds have been reported to exert an inhibitory effect on food intake and growth by decreasing protein digestibility (Tebib et al 1994). In this experiment, administration of AAE (150 mg/kg/d b. w.) to the CED-fed ICR mice showed no significant difference on levels of weight gain, food intake and feeding efficiency.…”

Section: Resultsmentioning

confidence: 65%

Hypocholesterolemic effects of Auricularia auricula ethanol extract in ICR mice fed a cholesterol-enriched diet

Gang

Luo

et al. 2010

J Food Sci Technol

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The cholesterol-lowering properties of Auricularia auricula are commonly attributed to the presence of polysaccharides based on previous research. The present study was designed to investigate the effects of ethanol extract of A. auricula (AAE) on hypercholesterolemia in ICR mice. AAE contained more than 16% (g/g) polyphenolic compounds, excluding other interfering factors such as polysaccharides, water-soluble fibre and protein. Thirtysix mice were randomly assigned to three groups (n=12). The experimental group was fed cholesterol-enriched diet (CED) with oral administration of AAE (150 mg/kg/d b.w.) for 8-week, normal control group and CED control group received either a regular diet (RD) or CED along with oral administration of equal volume distilled water. Serum lipid profiles and antioxidant status were measured in addition to fecal neutral cholesterol and bile acids. AAE showed a remarkable hypocholesterolemic effect, improving antioxidant status, decreasing the level of total cholesterol and atherosclerosis index, increasing the level of high-density lipoprotein cholesterol and fecal excretion of bile acids. No apparent effects on serum triglycerides, low-density lipoprotein cholesterol, fecal excretion of neutral cholesterol and feeding efficiency were observed among all groups. These results indicated that A. auricula functional components, which prevented hypercholesterolemia contained polyphenolic compounds, in addition to polysaccharides.

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“…Yamakoshi et al 17) reported that proanthocyanidins, the major polyphenols in red wine, might trap reactive oxygen species in aqueous components such as plasma and intestinal fluid of the arterial wall, thereby inhibiting oxidation of LDL and showing an antiatherosclerotic activity. Tebib et al 19) showed that polymeric grape seed tannins exert a hypocholesterolemic effect in rats fed a high-cholesterol diet. They also reported that dietary grape seed tannins have a pronounced antihypercholesterolemic effect in rats by enhancing reverse cholesterol transport and also reducing in- testinal cholesterol absorption and increasing bile acid excretion.…”

Section: Discussionmentioning

confidence: 99%

“…[5][6][7] GSP has various physiological effects in vivo, such as antioxidant effects, 8,9) protection against X-ray and ultraviolet rays, 10,11) chemoprevention, 12,13) anti-cancer or anti-tumor effects, [14][15][16] and inhibitory effects against atherosclerosis and hypercholesterolemia. [17][18][19][20] Recently, GSP has been considered as a potential health-food ingredient because of these beneficial properties. 21) No toxicity of GSP has been reported, [22][23][24] although GSP interacts with some kind of proteins.…”

Section: Introductionmentioning

confidence: 99%

Effects of Grape Seed Polyphenols on Serum and Hepatic Lipid Contents and Fecal Steroid Excretion in Normal and Hypercholesterolemic Rats.

Nakamura¹,

Tonogai²

2002

JOURNAL OF HEALTH SCIENCE

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The effects of grape seed polyphenol (GSP) administered orally at doses of 0.01-1.0 g/kg per day to normal and hypercholesterolemic rats for 28 and 36 days, respectively, was evaluated by measuring changes both in the concentrations of serum and hepatic lipids and in fecal steroid excretion. Body weight gain decreased dose-dependently both in normal and hypercholesterolemic rats. Relative weight of the liver was significantly lower in normal rats given more than 0.2 g/kg GSP compared with control rats. Compared with control groups, relative weight of the liver was significantly lower in normal rats given more than 0.2 g/kg GSP, and in hypercholesterolemic rats given more than 0.1 g/kg GSP, respectively. In hypercholesterolemic rats, food or calorie intake was significantly lower in rats given more than 0.1 g/kg GSP than in control rats. Dose-dependency was observed in serum concentrations of serum triglycerides and thiobarbituric acid reactive substances and the content of hepatic phospholipids in normal rats, and in serum concentration and hepatic content of triglycerides in hypercholesterolemic rats. A significant increase in fecal excretions of neutral steroids and bile acids was found in normal rats given a dose of 1.0 g/kg GSP. Dose-dependent decrease of 12-keto lithocholic acid and increase of lithocholic acid were also observed. By contrast, there was no significant change in fecal excretions of neutral steroids and bile acids in hypercholesterolemic rats. Thus, GSP seems to affect lipid metabolism in rats by lowering the concentrations of serum and hepatic triglycerides rather than by altering the metabolism of cholesterol.

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Polymeric grape seed tannins prevent plasma cholesterol changes in high-cholesterol-fed rats

Cited by 78 publications

References 23 publications

Antihyperlipidemic, antioxidant and weightlowering effects of “Vitalplant”

Antihyperlipidemic, antioxidant and weightlowering effects of “Vitalplant”

Hypocholesterolemic effects of Auricularia auricula ethanol extract in ICR mice fed a cholesterol-enriched diet

Effects of Grape Seed Polyphenols on Serum and Hepatic Lipid Contents and Fecal Steroid Excretion in Normal and Hypercholesterolemic Rats.

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