Polymeric controlled release inhalable powder produced by vibrational spray-drying: One-step preparation and in vitro lung deposition

Inhalable resveratrol microparticles produced by vibrational atomization spray drying for treating pulmonary arterial hypertension

“…Most particles were obtained in the designed inhaled formulation, with particle sizes ranging from 1 to 5 mm for their maximum efficiency deposition in the deepest lung [11,33]. Although particles larger than 5 mm would be deposited in the throat and easily cleared, the smaller particles above 0.5 mm may not be effective due to the Brownian motion in the airstream and can be exhaled during breathing [2,24].…”

“…These carriers, such as microparticles, can also impart the drugs with great properties, such as increased bioavailability [8] and drug stability [9], and they can deliver the drugs to specific targets [10]. Using a technology recently developed by Buchi Labortechnik, it is possible to obtain dry powders with an aerodynamic diameter between 1 and 5 mm to be efficiently deposited in the lower respiratory tract [11,12]. The Nano Spray Dryer B-90 ® is a new generation of laboratory-scale spray dryers, and it brings improvements compared to conventional spray dryers, such as better yields and powders with reduced particle sizes [12e15].…”

Comparison of spray drying, electroblowing and electrospinning for preparation of Eudragit E and itraconazole solid dispersions

“…Although SD is widely used in pharmaceutical technology for preparing micro-and/or nanoparticles (Asker and Becker, 1966;Draheim et al, 2015;Fontana et al, 2014), it has some disadvantages. SD technologies are energy consuming, heat-sensitive APIs can be decomposed during the drying process, and furthermore, the separation and handling of the produced fine powder can cause difficulties (Broadhead et al, 1992;Cal and Sollohub, 2010).…”

Unveiling the mechanism of antisolvent vapour precipitation in producing ultrafine spherical particles

“…Recently, studies have been done to extend its application to control the release of inhalable powders [13]. Polymers structure, molecular weight, linearity, intra-and intermolecular interactions determine its thermal, physical and mechanical properties [14].…”