Polymeric Biomaterials in Tissue Engineering and Regenerative Medicine

Tang, Xiaoyan; Thankappan, Shalumon Kottappally; Lee, Paul; Fard, Sahar E.; Harmon, Matthew; Tran, Katelyn; Yu, Xiaojun

doi:10.1016/b978-0-12-396983-5.00022-3

Cited by 62 publications

(29 citation statements)

References 193 publications

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“…Natural polymers like chitosan, collagen, elastin and hyaluronic acid are preferable for biomedical applications such as tissue engineering, since they simulate the native materials found in biological systems [18]. However, poor mechanical properties of such natural polymers limit their use in mechanically demanding environments.…”

Section: Opportunities For Pla Blendsmentioning

confidence: 99%

Poly(lactic acid) blends in biomedical applications

Saini

Arora

Kumar

2016

Advanced Drug Delivery Reviews

415

258

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Section: Opportunities For Pla Blendsmentioning

confidence: 99%

Poly(lactic acid) blends in biomedical applications

Saini

Arora

Kumar

2016

Advanced Drug Delivery Reviews

415

258

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“…Composite materials which contain polymeric and inorganic units have been widely used for various applications including medical purposes [24], tissue engineering [25], and mainly in preparation of membranes [26]. This is due to their better and more practical performance parameters [27,28].…”

Section: Biorefinery [16] and Etcmentioning

confidence: 99%

TiO2 nanocomposite based polymeric membranes: A review on performance improvement for various applications in chemical engineering processes

Bet-Moushoul

Mansourpanah

Farhadi

et al. 2016

Chemical Engineering Journal

338

130

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“…In future investigations, it would be interesting to use PLA blends to mimic the extracellular matrix structure. PLA is very hydrophobic, but it can be modified with other polymers like collagen or hyaluronic acid [ 42 , 43 , 44 ]. PLA blends enhanced cell viability, endothelization, and cell morphology [ 45 ].…”

Section: Discussionmentioning

confidence: 99%

Screening of Additive Manufactured Scaffolds Designs for Triple Negative Breast Cancer 3D Cell Culture and Stem-Like Expansion

Polonio‐Alcalá

Rabionet

Guerra

et al. 2018

IJMS

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Breast cancer stem cells (BCSCs) are tumor-initiating cells responsible for metastasis and tumor reappearance, but their research is limited by the impossibility to cultivate them in a monolayer culture. Scaffolds are three-dimensional (3D) cell culture systems which avoid problems related with culturing BCSC. However, a standardized scaffold for enhancing a BCSC population is still an open issue. The main aim of this study is to establish a suitable poly (lactic acid) (PLA) scaffold which will produce BCSC enrichment, thus allowing them to be studied. Different 3D printing parameters were analyzed using Taguchi experimental design methods. Several PLA scaffold architectures were manufactured using a Fused Filament Fabrication (FFF) 3D printer. They were then evaluated by cell proliferation assay and the configurations with the highest growth rates were subjected to BCSC quantification by ALDH activity. The design SS1 (0.2 mm layer height, 70% infill density, Zigzag infill pattern, 45° infill direction, and 100% flow) obtained the highest proliferation rate and was capable of enhancing a ALDH+ cell population compared to 2D cell culture. In conclusion, the data obtained endorse the PLA porous scaffold as useful for culturing breast cancer cells in a microenvironment similar to in vivo and increasing the numbers of BCSCs.

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Polymeric Biomaterials in Tissue Engineering and Regenerative Medicine

Cited by 62 publications

References 193 publications

Poly(lactic acid) blends in biomedical applications

Poly(lactic acid) blends in biomedical applications

TiO2 nanocomposite based polymeric membranes: A review on performance improvement for various applications in chemical engineering processes

Screening of Additive Manufactured Scaffolds Designs for Triple Negative Breast Cancer 3D Cell Culture and Stem-Like Expansion

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