Polymeric Biomaterials in Clinical Practice

Marjanović-Balabań, Željka; Jelić, Dijana

doi:10.1007/978-3-319-68025-5_4

Cited by 9 publications

(11 citation statements)

References 24 publications

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“…Polymer‐based devices with complex geometry are ubiquitous in a wide range of areas including bioengineering, medical and clinical devices, microfluidics, and soft robotics . In many applications, these polymer devices are used in close contact with human body.…”

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confidence: 89%

Multifunctional “Hydrogel Skins” on Diverse Polymers with Arbitrary Shapes

et al. 2018

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Slippery and hydrophilic surfaces find critical applications in areas as diverse as biomedical devices, microfluidics, antifouling, and underwater robots. Existing methods to achieve such surfaces rely mostly on grafting hydrophilic polymer brushes or coating hydrogel layers, but these methods suffer from several limitations. Grafted polymer brushes are prone to damage and do not provide sufficient mechanical compliance due to their nanometer‐scale thickness. Hydrogel coatings are applicable only for relatively simple geometries, precluding their use for the surfaces with complex geometries and features. Here, a new method is proposed to interpenetrate hydrophilic polymers into the surface of diverse polymers with arbitrary shapes to form naturally integrated “hydrogel skins.” The hydrogel skins exhibit tissue‐like softness (Young's modulus ≈ 30 kPa), have uniform and tunable thickness in the range of 5–25 µm, and can withstand prolonged shearing forces with no measurable damage. The hydrogel skins also provide superior low‐friction, antifouling, and ionically conductive surfaces to the polymer substrates without compromising their original mechanical properties and geometry. Applications of the hydrogel skins on inner and outer surfaces of various practical polymer devices including medical tubing, Foley catheters, cardiac pacemaker leads, and soft robots on massive scales are further demonstrated.

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confidence: 89%

Multifunctional “Hydrogel Skins” on Diverse Polymers with Arbitrary Shapes

et al. 2018

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“…To some extent this result is not surprising, considering that both silver and PTFE are FDA-approved biomaterials for urinary catheter coatings. 51,52 However, previous studies have indicated that an overdose of Ag can induce cytotoxicity toward mammal cells due to the fast release and storage of toxic Ag + and the adherence of AgNP on cell membrane may further induce cell apoptosis. 53 In our experiments, the release of Ag + from the Ag-PTFE-coated catheters proceeded in a two-phase manner that large amounts of Ag + were released in the initial 3 days and it became relatively slower and steady during the next 10 days.…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

Enhanced Antibacterial and Antiadhesive Activities of Silver-PTFE Nanocomposite Coating for Urinary Catheters

Zhang

Wang

Liang

et al. 2019

ACS Biomater. Sci. Eng.

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Catheter-associated urinary tract infection (CAUTI) presents a significant health problem worldwide and is associated with increased morbidity and mortality. Herein, a silver-polytetrafluoroethylene (Ag-PTFE) nanocomposite coating for catheters was developed via a facile wet chemistry method. Benefiting from the synergistic effect of Ag and PTFE, the as-prepared Ag-PTFE-coated catheter exhibited enhanced antibacterial and antiadhesive activities against two CAUTI-associated strains: E. coli WT F1693 and S. aureus F1557. Compared to the uncoated commercial silicone catheters and the Ag-coated catheters, the Ag-PTFE-coated catheters were able to reduce bacterial adhesion by up to 60.3% and 55.2%, respectively. The Ag-PTFE-coated catheters also exhibited strong antibiofilm activity, reducing biofilm coverage by up to 97.4% compared with the commercial silicone catheters. In an in vitro bladder model, the Ag-PTFE-coated catheter displayed excellent anti-infection efficacy against bacteriuria, extending the lifetime of silicone catheters from a mean of 6 days to over 40 days. The Ag-PTFE coating also showed good biocompatibility with fibroblast cells in culture, making it a prospective strategy to overcome current challenges in CAUTI.

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“…Medical devices and implants comprise an important tool in regenerative medicine to improve the quality of daily life and extending the functionality of the body systems [1,2]. Biomedical research has been investing in devices that can replace the origin tissue and also treat the problem [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Assessment of implantable drug delivery technology: poly (3-hydroxybutyrate) / polypropylene glycol films containing simvastatin

et al. 2021

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Natural polymers have attracted much attention in recent years for the study of new drug delivery systems. These materials are used as polymer matrices to protect the active drug from degradation in the biological environment and to improve the release kinetics of the drug. The poly(3-hydroxybutyrate) (PHB) is a natural biocompatible polymer, widely used in combination with other polymers to improve their physicochemical properties. Thus, this work aimed to develop and characterize films of PHB and blends containing polypropylene glycol (PPG) with different concentrations of simvastatin (Simv.). The films were prepared by casting, dissolving PHB or a blend of PHB / PPG (90:10) and (5% or 25 %) Simv. in chloroform (2% w/v). The solutions were stirred for 3 h and then transferred to an appropriate glass mold for solvent evaporation for 48 h at room temperature. The obtained films were characterized by Fourier Transform Infrared (FTIR) spectroscopy, thermogravimetric analysis, scanning electron microscopy (SEM), optical microscopy, in vitro degradation study, and in vivo biocompatibility test. The results showed that PHB and blends of PHB / PPG are able to form a homogeneous film with the drug inside. A great amount of drug lead to the instability of polymeric matrixes and resulted in a facilitated film degradation. On the other hand, devices with 5% of Simv. were more stable, which suggests the application of these films for biomedical devices. In vivo studies revealed that the films can interact with the animals' organism, and do not undergo rejection. Hence, these films hold an innovative alternative in tissue engineering to promotes drug release by diffusion and erosion of the polymeric material.

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Polymeric Biomaterials in Clinical Practice

Cited by 9 publications

References 24 publications

Multifunctional “Hydrogel Skins” on Diverse Polymers with Arbitrary Shapes

Multifunctional “Hydrogel Skins” on Diverse Polymers with Arbitrary Shapes

Enhanced Antibacterial and Antiadhesive Activities of Silver-PTFE Nanocomposite Coating for Urinary Catheters

Assessment of implantable drug delivery technology: poly (3-hydroxybutyrate) / polypropylene glycol films containing simvastatin

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