Polymeric biomaterials: Advanced drug delivery systems in osteoarthritis treatment

Liu, Lin; Tang, Haifeng; Wang, Yanjun

doi:10.1016/j.heliyon.2023.e21544

Cited by 5 publications

(6 citation statements)

References 77 publications

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“…Hydrogels with silk can be utilized for drug delivery in osteoarthritis treatment [ 125 , 126 ] or can act as self-healing scaffolds for bone regeneration, through the filling of bone defects [ 127 ]. Self-healing silk hydrogel can also be used as a flexible strain sensor with self-adhesive property [ 128 ] that can be used for the development of wearables, with immense significance, as well, for medical diagnostics.…”

Section: Spider Silk Structuresmentioning

confidence: 99%

“…Soft porous natural materials represent very suitable materials for drug delivery systems, and silk-based biomaterials have shown different possibilities for tailoring such systems [ 3 , 91 , 103 , 109 , 125 ], including in the scope of bone tissue engineering [ 8 ]. Silk fibroin has shown good adjustability to suit different drug delivery systems, including hydrogels [ 116 , 117 , 121 ] or coatings and thin films [ 103 ].…”

Section: Spider Silk In Nanomedicinementioning

confidence: 99%

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Review of Spider Silk Applications in Biomedical and Tissue Engineering

Branković,

Zivic,

Grujovic

et al. 2024

Biomimetics

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This review will present the latest research related to the production and application of spider silk and silk-based materials in reconstructive and regenerative medicine and tissue engineering, with a focus on musculoskeletal tissues, and including skin regeneration and tissue repair of bone and cartilage, ligaments, muscle tissue, peripheral nerves, and artificial blood vessels. Natural spider silk synthesis is reviewed, and the further recombinant production of spider silk proteins. Research insights into possible spider silk structures, like fibers (1D), coatings (2D), and 3D constructs, including porous structures, hydrogels, and organ-on-chip designs, have been reviewed considering a design of bioactive materials for smart medical implants and drug delivery systems. Silk is one of the toughest natural materials, with high strain at failure and mechanical strength. Novel biomaterials with silk fibroin can mimic the tissue structure and promote regeneration and new tissue growth. Silk proteins are important in designing tissue-on-chip or organ-on-chip technologies and micro devices for the precise engineering of artificial tissues and organs, disease modeling, and the further selection of adequate medical treatments. Recent research indicates that silk (films, hydrogels, capsules, or liposomes coated with silk proteins) has the potential to provide controlled drug release at the target destination. However, even with clear advantages, there are still challenges that need further research, including clinical trials.

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Section: Spider Silk Structuresmentioning

confidence: 99%

Section: Spider Silk In Nanomedicinementioning

confidence: 99%

Review of Spider Silk Applications in Biomedical and Tissue Engineering

Branković,

Zivic,

Grujovic

et al. 2024

Biomimetics

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“…Therefore, research progress in this specic eld can be highly diverse, as demonstrated by the most recent reviews which focus on the nanocomposites of gelatin and various nanoparticles, 1 nano-based biomaterials for leiomyosarcoma therapy, 2 dynamic biomaterials based on material nanoarchitectonics, 3 hydroxyapatite nanoparticles and nanostructured materials, 4 intelligent biomaterials for micro and nanoscale additive manufacturing, 5 nanoscale surface coatings and topographies for neural interfaces, 6 and polymeric drug delivery systems including hydrogels, nanobers, and microspheres. 7,8 In this themed collection, made up of review articles and research papers, the emphasis is rmly placed on the demonstration of links between nano and microscale surface modications, and their effects on mechanical, physical, chemical, and biological properties. The reviews focus on general presentations of surface modications of implants, nanoparticles used in wound healing, ceriabased coatings for biodegradable magnesium alloy, and hydrogels used for bone repair.…”

Section: Andrzej Zieli ńSki * and Beata Majkowska-marzecmentioning

confidence: 99%

“…Therefore, research progress in this specific field can be highly diverse, as demonstrated by the most recent reviews which focus on the nanocomposites of gelatin and various nanoparticles, 1 nano-based biomaterials for leiomyosarcoma therapy, 2 dynamic biomaterials based on material nanoarchitectonics, 3 hydroxyapatite nanoparticles and nanostructured materials, 4 intelligent biomaterials for micro and nanoscale additive manufacturing, 5 nanoscale surface coatings and topographies for neural interfaces, 6 and polymeric drug delivery systems including hydrogels, nanofibers, and microspheres. 7,8 …”

mentioning

confidence: 99%

Introduction to the RSC Advances themed collection on nano and microscale modifications of biomaterials

Zieliński,

Majkowska-Marzec

2024

RSC Adv.

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“…As an alternative, in the second half of the 20th century, polymers were introduced into medicine and pharmacy. They brought along revolutionary solutions to the treatment of various disorders and diseases and helped in prosthetics [ 4 , 5 ], drug delivery [ 6 , 7 ], and wound healing [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Polymer–Metal Bilayer with Alkoxy Groups for Antibacterial Improvement

Idriss,

Kutová,

Rimpelová

et al. 2024

Polymers

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Many bio-applicable materials, medical devices, and prosthetics combine both polymer and metal components to benefit from their complementary properties. This goal is normally achieved by their mechanical bonding or casting only. Here, we report an alternative easy method for the chemical grafting of a polymer on the surfaces of a metal or metal alloys using alkoxy amine salt as a coupling agent. The surface morphology of the created composites was studied by various microscopy methods, and their surface area and porosity were determined by adsorption/desorption nitrogen isotherms. The surface chemical composition was also examined by various spectroscopy techniques and electrokinetic analysis. The distribution of elements on the surface was determined, and the successful bonding of the metal/alloys on one side with the polymer on the other by alkoxy amine was confirmed. The composites show significantly increased hydrophilicity, reliable chemical stability of the bonding, even interaction with solvent for thirty cycles, and up to 95% less bacterial adhesion for the modified samples in comparison with pristine samples, i.e., characteristics that are promising for their application in the biomedical field, such as for implants, prosthetics, etc. All this uses universal, two-step procedures with minimal use of energy and the possibility of production on a mass scale.

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Polymeric biomaterials: Advanced drug delivery systems in osteoarthritis treatment

Cited by 5 publications

References 77 publications

Review of Spider Silk Applications in Biomedical and Tissue Engineering

Review of Spider Silk Applications in Biomedical and Tissue Engineering

Introduction to the RSC Advances themed collection on nano and microscale modifications of biomaterials

Polymer–Metal Bilayer with Alkoxy Groups for Antibacterial Improvement

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