Polymeric and non-polymeric oxaliplatin nanomedicine for cancer therapy: A comprehensive review

Pourmadadi, Mehrab; Shaghaghi, Meysam; Arshad, Rabia; Kharaba, Zelal; Maleki-baladi, Reza; Rahdar, Abbas; Fathi-karkan, Sonia; Pandey, Sadanand

doi:10.1016/j.eurpolymj.2024.112870

Cited by 7 publications

(1 citation statement)

References 129 publications

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“…Furthermore, the protein corona’s dynamic nature adds an additional layer of complexity to biomarker discovery. As nanoparticles interact with various biological fluids, including blood and interstitial fluid, the composition of the protein corona may evolve over time, reflecting the dynamic changes in the tumor microenvironment. , Monitoring these changes can provide real-time information about the disease progression, enabling the development of adaptive and personalized treatment strategies for colorectal cancer patients. , Despite the tremendous potential of nanomedicine and the protein corona in biomarker discovery, challenges remain in translating these findings into clinical applications. Standardization of nanoparticle characterization, corona analysis, and data interpretation is crucial for ensuring the reproducibility and reliability of the results across different studies.…”

Section: Molecular Profiling Of Colorectal Cancermentioning

confidence: 99%

Advances in Precision Medicine Approaches for Colorectal Cancer: From Molecular Profiling to Targeted Therapies

Kiran,

Yashaswini,

Maheshwari

et al. 2024

ACS Pharmacol. Transl. Sci.

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Precision medicine is transforming colorectal cancer treatment through the integration of advanced technologies and biomarkers, enhancing personalized and effective disease management. Identification of key driver mutations and molecular profiling have deepened our comprehension of the genetic alterations in colorectal cancer, facilitating targeted therapy and immunotherapy selection. Biomarkers such as microsatellite instability (MSI) and DNA mismatch repair deficiency (dMMR) guide treatment decisions, opening avenues for immunotherapy. Emerging technologies such as liquid biopsies, artificial intelligence, and machine learning promise to revolutionize early detection, monitoring, and treatment selection in precision medicine. Despite these advancements, ethical and regulatory challenges, including equitable access and data privacy, emphasize the importance of responsible implementation. The dynamic nature of colorectal cancer, with its tumor heterogeneity and clonal evolution, underscores the necessity for adaptive and personalized treatment strategies. The future of precision medicine in colorectal cancer lies in its potential to enhance patient care, clinical outcomes, and our understanding of this intricate disease, marked by ongoing evolution in the field. The current reviews focus on providing in-depth knowledge on the various and diverse approaches utilized for precision medicine against colorectal cancer, at both molecular and biochemical levels.

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Section: Molecular Profiling Of Colorectal Cancermentioning

confidence: 99%

Advances in Precision Medicine Approaches for Colorectal Cancer: From Molecular Profiling to Targeted Therapies

Kiran,

Yashaswini,

Maheshwari

et al. 2024

ACS Pharmacol. Transl. Sci.

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Research on lncRNA CTBP1-DT as a potential therapeutic target to regulate cell function in colorectal cancer

Fan,

Xu,

Kuang

2024

Discov Onc

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Background Colorectal cancer, which originates from the human colon or rectum, is one of the leading causes of death worldwide. Timely diagnosis and interventional therapy can significantly improve the prognostic survival of colorectal cancer patients, making regular screening and early detection essential. Aim To investigate the regulatory function of lncRNA CTBP1-DT (CTBP1-DT) on colorectal cancer cells and to assess its diagnostic significance. Methods A total of 102 patients with colorectal cancer and 92 healthy individuals were selected. The levels of CTBP1-DT and microRNA-30a-5p (miR-30a-5p) in serum and cell samples of the above subjects were compared by RT-qPCR. The effects of CTBP1-DT and miR-30a-5p dysregulation on the biological functions of colorectal cancer cells were analyzed via CCK-8, flow cytometry and Transwell assays. In addition, the ability of CTBP1-DT and miR-30a-5p to early identify colorectal cancer patients was determined through ROC curve. Results Serum CTBP1-DT was elevated in patients with colorectal cancer, which was obviously higher than in healthy controls. The expression of serum miR-30a-5p was downregulated in colorectal cancer. Both CTBP1-DT and miR-30a-5p have the value of distinguishing colorectal cancer, and the combined diagnostic ability is higher. Knockdown of CTBP1-DT directly targeted miR-30a-5p to repress cell activity and metastatic ability, whereas deregulation of miR-30a-5p eliminated the above inhibitory effects. Conclusion Overexpression of CTBP1-DT has a certain application potential in the diagnosis of colorectal cancer and may be a therapeutic target for colorectal cancer.

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Enhanced delivery of doxorubicin for breast cancer treatment using pH-sensitive starch/PVA/g-C3N4 hydrogel

Alipournazari,

Pourmadadi,

Abdouss

et al. 2024

International Journal of Biological Macromolecules

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Polymeric and non-polymeric oxaliplatin nanomedicine for cancer therapy: A comprehensive review

Cited by 7 publications

References 129 publications

Advances in Precision Medicine Approaches for Colorectal Cancer: From Molecular Profiling to Targeted Therapies

Advances in Precision Medicine Approaches for Colorectal Cancer: From Molecular Profiling to Targeted Therapies

Research on lncRNA CTBP1-DT as a potential therapeutic target to regulate cell function in colorectal cancer

Enhanced delivery of doxorubicin for breast cancer treatment using pH-sensitive starch/PVA/g-C3N4 hydrogel

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