Polymerase chain reaction on cerebrospinal fluid for diagnosis of virus-associated opportunistic diseases of the central nervous system in HIV-infected patients

Cinque, Paola; Vago, Luca; Dahl, Helena; Brytting, Maria; Terreni, Maria Rosa; Fornara, C.; Racca, Sara; Castagna, Antonella; Monforte, Antonella d’Arminio; Wahrén, Britta; Lazzarin, Adriano; Linde, Annika

doi:10.1097/00002030-199610090-00004

Cited by 184 publications

(155 citation statements)

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“…HHV-6 was found by PCR in only 2.2% of 365 patients. The detection rate was substantially lower than those found for CMV, EBV and JCV (16%, 12% and 9%, respectively) 4 . Liedke et al 6 , in contrast, reported that HHV-6 DNA was found in the CSF samples of 30% of HIV-infected patients with neurological disease.…”

Section: Referencescontrasting

confidence: 58%

“…However, the role of HHV-6 in the pathogenesis of CNS disease remains unclear 4,5 . Bossolasco et al 5 evaluated the frequency of HHV-6 DNA detection in the CSF of patients infected with HIV/ AIDS and its possible relation to neurological disease.…”

Section: Referencesmentioning

confidence: 99%

“…Recently, HHV-6 has been associated as an emerging pathogen in patients with AIDS and recipients of bone marrow and solid organ transplants. However, there are few reports related HHV-6 to the immunodeficiency caused by HIV/AIDS 4 . In patients with AIDS, reactivation of HHV-6 infection presents, generally, as an acute and fatal meningoencephalitis 2 .…”

Section: Introductionmentioning

confidence: 99%

“…Every tube has an internal amplification control, and the amplified products are detected by hybridization with specific probes in a microplate. The analytical sensitivity reported by the manufacturer is two genome equivalents for HSV-1, HSV-2 and EBV, and between 2 and 20 genome equivalents for HVZ, HHV-6 and CMV 4 .…”

Section: Introductionmentioning

confidence: 99%

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Human herpesvirus 6: report of emerging pathogen in five patients with HIV/AIDS and review of the literature

Corti

Villafañe

Trione

et al. 2011

Rev. Soc. Bras. Med. Trop.

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The reactivation of human herpesvirus 6 (HHV-6) in patients with AIDS can result in an acute and severe diffuse meningoencephalitis. We describe the epidemiological, clinical and outcome findings of five patients with diagnosis of HIV/AIDS and central nervous system involvement (CNS) due to HHV-6. Fever was present in all the patients. Meningeal compromise, seizures and encephalitis were present in some of the patients. Polymerase chain reaction (PCR) of cerebrospinal fluid (CSF) specimens was positive for HHV-6 in all the patients. HHV-6 should be included among opportunistic and emerging pathogens that involve the CNS in patients with AIDS.

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Section: Referencescontrasting

confidence: 58%

Section: Referencesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Human herpesvirus 6: report of emerging pathogen in five patients with HIV/AIDS and review of the literature

Corti

Villafañe

Trione

et al. 2011

Rev. Soc. Bras. Med. Trop.

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“…These tumors have a tendency to occur late in the course of HIV infection and show EBV association in virtually 100% of the cases [121]. A few studies have reported that detection of EBV in the cerebrospinal fluid of HIV-positive patients with a CNS lesion infers a diagnosis of lymphoma [122,123]. These lymphomas have been reported to express all EBV latent encoded proteins (latency III), although the role of EBV in the pathogenesis of these disorders remains unknown [121].…”

Section: Ebv and Hiv-related Lymphoproliferative Disordersmentioning

confidence: 99%