Polymerase chain reaction in the diagnosis of invasive aspergillosis

Hızel, Kenan; Köktürk, Nurdan; Kalkancı, Ayşe; Öztürk, Can; Kuştımur, Semra; Tufan, Müge Aydın

doi:10.1111/j.1439-0507.2004.00944.x

Cited by 18 publications

(3 citation statements)

References 32 publications

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“…An additional method for IA diagnosis is PCR [84]. The sensitivity and specificity of PCR in BAL fluid is 67%–100% and 55%–95%, whereas in serum the values are 100% and 65%–92% respectively [85,86]. A possible drawback of PCR diagnostics is the difficulty in discrimination between colonisation and infection [87].…”

Section: Aspergillusmentioning

confidence: 99%

Invasive Fungal Infections in the ICU: How to Approach, How to Treat

et al. 2014

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Abstract:Invasive fungal infections are a growing problem in critically ill patients and are associated with increased morbidity and mortality. Most of them are due to Candida species, especially Candida albicans. Invasive candidiasis includes candidaemia, disseminated candidiasis with deep organ involvement and chronic disseminated candidiasis. During the last decades rare pathogenic fungi, such as Aspergillus species, Zygomycetes, Fusarium species and Scedosporium have also emerged. Timely diagnosis and proper treatment are of paramount importance for a favorable outcome. Besides blood cultures, several laboratory tests have been developed in the hope of facilitating an earlier detection of infection. The antifungal armamentarium has also been expanded allowing a treatment choice tailored to individual patients' needs. The physician can choose among the old class of polyenes, the older and newer azoles and the echinocandins. Factors related to patient's clinical situation and present co-morbidities, local epidemiology data and purpose of treatment (prophylactic, pre-emptive, empiric or definitive) should be taken into account for the appropriate choice of antifungal agent.

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Section: Aspergillusmentioning

confidence: 99%

Invasive Fungal Infections in the ICU: How to Approach, How to Treat

et al. 2014

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“…It is worth mentioning that the currently available brand of piperacillin/tazobactam preparations is less likely to cause false-positive GM results ( 16 ). Furthermore, detecting Aspergillus nuclear material via polymerase chain reaction testing on serum, body fluids or tissue has been another development in the field and is currently undergoing rigorous testing ( 17 ).…”

Section: Discussionmentioning

confidence: 99%

A 52‐Year‐Old HIV‐Positive Man with Abdominal Pain

Mehmood

Chua

Khasawneh

2015

Canadian Journal of Infectious Diseases and Medical Microbiolog

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“…β-D-glucan is, like galactomannan, a cell wall component, which is also found in body fluids and its presence indicates the probability of infection. PCR, although it is a method with high sensitivity and specificity, is cumbersome and lacks in discrimination power between colonization and infection [ 60 , 61 ]. Quantitative real time PCR may pose as a useful alternative in the diagnosis of invasive aspergillosis [ 62 ].…”

Section: Reviewmentioning

confidence: 99%

How to treat fungal infections in ICU patients

2015

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Fungal infections represent a major burden in the critical care setting with increasing morbidity and mortality. Candidiasis is the leading cause of such infections, with C. albicans being the most common causative agent, followed by Aspergillosis and Mucormycosis. The diagnosis of such infections is cumbersome requiring increased clinical vigilance and extensive laboratory testing, including radiology, cultures, biopsies and other indirect methods. However, it is not uncommon for definitive evidence to be unavailable. Risk and host factors indicating the probability of infections may greatly help in the diagnostic approach. Timely and adequate intervention is important for their successful treatment. The available therapeutic armamentarium, although not very extensive, is effective with low resistance rates for the newer antifungal agents. However, timely and prudent use is necessary to maximize favorable outcomes.

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Polymerase chain reaction in the diagnosis of invasive aspergillosis

Cited by 18 publications

References 32 publications

Invasive Fungal Infections in the ICU: How to Approach, How to Treat

Invasive Fungal Infections in the ICU: How to Approach, How to Treat

A 52‐Year‐Old HIV‐Positive Man with Abdominal Pain

How to treat fungal infections in ICU patients

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