“…mucosa , PVP, PVA and SA. PVP and PVA have been widely used as restorative materials because they offer a physiologically benign environment for cell proliferation and migration [ [37] , [38] , [39] , [40] ]. In addition, PVA is up to date the only one among vinyl polymers suited as a carbon and energy source for bacteria [ [41] , [42] , [43] ].…”
“…mucosa , PVP, PVA and SA. PVP and PVA have been widely used as restorative materials because they offer a physiologically benign environment for cell proliferation and migration [ [37] , [38] , [39] , [40] ]. In addition, PVA is up to date the only one among vinyl polymers suited as a carbon and energy source for bacteria [ [41] , [42] , [43] ].…”
“…These could be attributed to the combination of NAGA–NAGA H-bonding, NAGA–NAS H-bonding, and hydrophobic interactions of NAS, as illustrated in Scheme . The obtained UCST PNPs thereby can be developed into molecular switches and find applications in thermo-sensitive drug carriers or catalyst modulations. − …”
Section: Resultsmentioning
confidence: 99%
“…At a low concentration (<2 wt %), PNAGA exhibits upper critical solution temperature (UCST) behavior − and performs a thermo-reversible transition between two states: nanoparticles and soluble chains. ,− At a medium concentration (2–10 wt %), PNAGA forms hydrogels and exhibits a thermo-reversible gel–sol transition. , At a high concentration (>10 wt %), PNAGA forms hydrogels with high mechanical properties as a result of hydrophobic micro-domain formation that is driven by intermolecular H-bonds. − Besides, excellent biocompatibility has also been reported of PNAGA. , Thus, PNAGA-based polymers have been developed for biomedical applications, such as for in vivo drug delivery − or cell adhesion modulation − or as self-healing hydrogels ,− or ultralow fouling surfaces . However, these developments mainly focused on using PNAGA as hydrogels. − Investigations based on PNAGA as thermo-responsive nanoparticles are few, and so far ,only PNAGA as temperature-sensitive drug carriers or enzyme switches , have been reported. Considering that the nanoparticle bio-interfaces can produce diverse biological outcomes, addressing two key issues is important to expand the applications of PNAGA nanoparticles in biomedical fields.…”
Section: Introductionmentioning
confidence: 99%
“…24 However, these developments mainly focused on using PNAGA as hydrogels. 25−28 Investigations based on PNAGA as thermo-responsive nanoparticles are few, and so far ,only PNAGA as temperature-sensitive drug carriers 29 or enzyme switches 30,31 have been reported.…”
Poly(N-acryloyl glycinamide) (PNAGA)
can form
high-strength hydrogen bonds (H-bonds) through the dual amide motifs
in the side chain, allowing the polymer to exhibit gelation behavior
and an upper critical solution temperature (UCST) property. These
features make PNAGA a candidate platform for biomedical devices. However,
most applications focused on PNAGA hydrogels, while few focused on
PNAGA nanoparticles. Improving the UCST tunability and bio-interfacial
adhesion of the PNAGA nanoparticles may expand their applications
in biomedical fields. To address the issues, we established a reactive
H-bond-type P(NAGA-co-NAS) copolymer via reversible addition–fragmentation chain transfer polymerization
of NAGA and N-acryloxysuccinimide (NAS) monomers.
The UCST behaviors and the bio-interfacial adhesion toward the proteins
and cells along with the potential application of the copolymer nanoparticles
were investigated in detail. Taking advantage of the enhanced H-bonding
and reactivity, the copolymer exhibited a tunable UCST in a broad
temperature range, showing thermo-reversible transition between nanoparticles
(PNPs) and soluble chains; the PNPs efficiently bonded proteins into
nano-biohybrids while keeping the secondary structure of the protein,
and more importantly, they also exhibited good adhesion ability to
the cell membrane and significantly inhibited cell-specific propagation.
These features suggest broad prospects for the P(NAGA-co-NAS) nanoparticles in the fields of biosensors, protein delivery,
cell surface decoration, and cell-specific function regulation.
“…Compared with microgels, amphiphilic block copolymers as functional blend modifiers have gained increasing attention. 16–21 Herein, amphiphilic block copolymer polystyrene- b -poly( N -isopropylacrylamide- co -2-(acrylamido) phenylboronic acid) (PSNB) and poly(ether sulfone) (PES) were blended to prepare glucose-sensitive membrane. During the non-solvent induced phase separation (NIPS) process, amphiphilic polymers can be enriched at the interface between water and the membrane matrix.…”
Glucose-sensitive membrane has promising application in insulin release. Phenyboronic acid (PBA) is an important glucose reporter. Most of PBA-based glucose-sensitive materials are expansion-type, which cannot act as chemical valves in...
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