Polymer translocation under a pulling force: Scaling arguments and threshold forces

Menais, Timothée

doi:10.1103/physreve.97.022501

Cited by 19 publications

(15 citation statements)

References 58 publications

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“…Simulation results show that increasing the polymer-pore interaction energy slows down the translocation. Moreover, increasing the pore diameter makes the translocation faster which is in complete accordance with previous results [43,44].…”

Section: Discussionsupporting

confidence: 92%

Translocation through a narrow pore under a pulling force

Hamidabad

Abdolvahab

2019

Sci Rep

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We employ a three-dimensional molecular dynamics to simulate a driven polymer translocation through a nanopore by applying an external force, for four pore diameters and two external forces. To see the polymer and pore interaction effects on translocation time, we studied nine interaction energies. Moreover, to better understand the simulation results, we investigate polymer center of mass, shape factor and the monomer spatial distribution through the translocation process. Our results reveal that increasing the polymer-pore interaction energy is accompanied by an increase in the translocation time and decrease in the process rate. Furthermore, for pores with greater diameter, the translocation becomes faster. The shape analysis of the polymer indicates that the polymer shape is highly sensitive to the interaction energy. In great interactions, the monomers come close to the pore from both sides. As a result, the translocation becomes fast at first and slows down at last. Overall, it can be concluded that the external force does not play a major role in the shape and distribution of translocated monomers. However, the interaction energy between monomer and nanopore has a major effect especially on the distribution of translocated monomers on the trans side.

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Section: Discussionsupporting

confidence: 92%

Translocation through a narrow pore under a pulling force

Hamidabad

Abdolvahab

2019

Sci Rep

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“…A similar variational behavior of false〈τfalse〉 against the force f had been reported in the previous study of translocation using neutral polymers pulled from the head end [103,104]; the systems were found to be driven from a unbiased condition, in which false〈τfalse〉 was constant, to a biased one, in which false〈τfalse〉 decreased with increasing the pulling force. The asymptotic UB scaling line in the log-log plot of false〈τfalse〉 vs. N had been seen in the study using neutral chains as well [34].…”

Section: Resultssupporting

confidence: 80%

Translocation of Charged Polymers through a Nanopore in Monovalent and Divalent Salt Solutions: A Scaling Study Exploring over the Entire Driving Force Regimes

Hsiao

2018

Polymers

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Langevin dynamics simulations are performed to study polyelectrolytes driven through a nanopore in monovalent and divalent salt solutions. The driving electric field E is applied inside the pore, and the strength is varied to cover the four characteristic force regimes depicted by a rederived scaling theory, namely the unbiased (UB) regime, the weakly-driven (WD) regime, the strongly-driven trumpet (SD(T)) regime and the strongly-driven isoflux (SD(I)) regime. By changing the chain length N, the mean translocation time is studied under the scaling form ⟨ τ ⟩ ∼ N α E − δ . The exponents α and δ are calculated in each force regime for the two studied salt cases. Both of them are found to vary with E and N and, hence, are not universal in the parameter’s space. We further investigate the diffusion behavior of translocation. The subdiffusion exponent γ p is extracted. The three essential exponents ν s , q, z p are then obtained from the simulations. Together with γ p , the validness of the scaling theory is verified. Through a comparison with experiments, the location of a usual experimental condition on the scaling plot is pinpointed.

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“…This weak dependence with the polymer length N has been also confirmed by the stall force evaluation presented below in this paper. The presence of a threshold force that allows the translocation has been also observed in previous calculations [25,53].…”

Section: Resultssupporting

confidence: 76%

Force spectroscopy analysis in polymer translocation

Fiasconaro

Falo

2018

Phys. Rev. E

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This paper reports the force spectroscopy analysis of a polymer that translocates from one side of a membrane to the other side through an extended pore, pulled by a cantilever that moves with constant velocity against the damping and the potential barrier generated by the reaction of the membrane walls. The polymer is modeled as a beads-springs chain with both excluded volume and bending contributions, and moves in a stochastic three dimensional environment described by a Langevin dynamics at fixed temperature. The force trajectories recorded at different velocities reveal two exponential regimes: the force increases when the first part of the chain enters the pore, and then decreases when the first monomer reaches the trans region. The spectroscopy analysis of the force values permit the estimation of the limit force to allow the translocation, related to the free energy barrier. The stall force to maintain the polymer fixed has been also calculated independently, and its value confirms the force spectroscopy outcomes.

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Polymer translocation under a pulling force: Scaling arguments and threshold forces

Cited by 19 publications

References 58 publications

Translocation through a narrow pore under a pulling force

Translocation through a narrow pore under a pulling force

Translocation of Charged Polymers through a Nanopore in Monovalent and Divalent Salt Solutions: A Scaling Study Exploring over the Entire Driving Force Regimes

Force spectroscopy analysis in polymer translocation

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