2005
DOI: 10.1021/bm050232w
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Polymer Terminal Group Effects on Properties of Thermoresponsive Polymeric Micelles with Controlled Outer-Shell Chain Lengths

Abstract: Well-defined amphiphilic diblock copolymers comprising thermoresponsive polymer segments of poly(N-isopropylacrylamide-co-N,N-dimethylacrylamide) (PID) and hydrophobic polymer segments, poly(benzyl methacrylate) (PBzMA), were synthesized by controlled living radical polymerization. Terminal derivatization of PID segments to either hydroxyl or phenyl groups was achieved through reactions of coupling agents with thiol groups exposed by cleavage of terminal dithiobenzoate groups. Diblock copolymers formed core-sh… Show more

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Cited by 165 publications
(156 citation statements)
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“…With this new approach, a cell adhesion/de-adhesion surface can be prepared easily by varying polymerization time. Moreover, a "living" reactive group has been reserved in the terminal of polymer chain, which can produce various block copolymers via multistep RAFT polymerization [62,63]. Utilizing this unique property, a micropatterned temperature-responsive polymer brush surface has been fabricated to obtain a cell sheet with a well-controlled orientational structure [64].…”
Section: Micropatterned Temperature-responsive Polymer Brush Surfacesmentioning
confidence: 99%
“…With this new approach, a cell adhesion/de-adhesion surface can be prepared easily by varying polymerization time. Moreover, a "living" reactive group has been reserved in the terminal of polymer chain, which can produce various block copolymers via multistep RAFT polymerization [62,63]. Utilizing this unique property, a micropatterned temperature-responsive polymer brush surface has been fabricated to obtain a cell sheet with a well-controlled orientational structure [64].…”
Section: Micropatterned Temperature-responsive Polymer Brush Surfacesmentioning
confidence: 99%
“…2 To date, the fundamental composition in nearly all the thermoresponsive materials was the linear polymers with LCST property. [3][4][5] In other words, even though the thermoresponsive materials had some specific topology, such as hydrogel, 6 star or grafted polymer, [7][8][9] and polymeric micelles, 10,11 their LCST properties were only contributed by their fundamental composition of the thermoresponsive linear polymer, and were independent on their specific topology. Only very recently, perfectly branched and welldefined dendrimers exhibiting the LCST in aqueous media were addressed, and the LCSTs were significantly dependent on the spheroid-like geometry of dendrimers.…”
Section: Introductionmentioning
confidence: 99%
“…A reversible addition-fragmentation chain transfer (RAFT) agent, 2-(N-[2-hydroxyethyl]carbamoyl) prop-2-yl dithiobenzoate (HECPD), was prepared according to previous publications. 28,[31][32][33] The water used was purified by a Milli-Q water purification system (EMD Millipore, Billerica, MA, USA). The dialysis membrane was provided by Spectrum Medical Industries (Los Angeles, CA, USA).…”
mentioning
confidence: 99%