Polymer-polymer complexation in dilute aqueous solutions: poly(acrylic acid)-poly(ethylene oxide) and poly(acrylic acid)-poly(vinylpyrrolidone)

Pradip,; Maltesh, C.; Somasundaran, P.; Kulkarni, R. A.; Gundiah, S.

doi:10.1021/la00058a024

Cited by 74 publications

(34 citation statements)

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“…Pradip and Somasundaran 3 stated that PAA interacts with poly(ethylene oxide) (PEO) and PVP in aqueous solutions through hydrogen bonding and that the interactions between PAA and PVP were stronger than those between PAA and PEO because of the stronger hydrogen‐bonding capability of the pyrrollidone group in the PAA–PVP system.…”

Section: Resultsmentioning

confidence: 99%

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Infrared spectra of γ‐irradiated poly(acrylic acid)–polyacrylamide complex

Moharram

Rabie²,

El-Gendy

2002

J of Applied Polymer Sci

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Samples of polyacrylamide (PAAm), poly(acrylic acid) (PAA), and their complex were ␥-irradiated at different doses, namely 48, 96, and 144 KGy. The examination of the infrared spectra of these samples showed that there are no significant observable changes in their spectral features apart from slight changes in the intensities of the absorption bands. The analysis of the absorbances ratios (A 1700 cm Ϫ1 /A 1450 cm Ϫ1 ) and (A 1650 cm Ϫ1 /A 1450 cm Ϫ1 ), denoted as R 1 and R 2 , respectively, showed that these ratios depend on ␥-doses. It was found that in the case of PAA, R 1 assumed linear increase with increasing the dose to 96 KGy and then showed marked decrease. For the complex, R 1 increased slightly by increasing the dose to 96 KGy and then decreased. For PAAm, although irradiation with 48 KGy increases the values of R 2 , irradiation with 96 and 144 KGy decreases its value. On the other hand, for the complex, R 2 suggested slight decrease on irradiation with 48 KGy followed by continued increases with increasing the dose up to 144 KGy. The increase in R 1 and R 2 may be due to crosslinking as a result of the formation of free radicals. The decrease in these ratios after irradiation with 96 KGy may be due to degradation. It was concluded that ␥-irradiation has a lower effect on the complex (i.e., the complex has a structure which is different from those of PAA and PAAm).

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Section: Resultsmentioning

confidence: 99%

“…The pH of these mixtures was then adjusted by adding drops of 10% HCl until precipitation or phase separation takes place. 3 The dried precipitates were filtrated and washed with distilled water. The samples were then ground in an agate mortar, followed by sieving to a particle size of 100–120 μm, suitable for IR measurements.…”

Section: Methodsmentioning

confidence: 99%

Infrared spectra of γ‐irradiated poly(acrylic acid)–polyacrylamide complex

Moharram

Rabie²,

El-Gendy

2002

J of Applied Polymer Sci

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“…The unshared electron pairs of the ether oxygens, which give the polymer strong hydrogen bonding affinity, can also take part in association reactions with a variety of monomeric and polymeric electron acceptors (42,43). These include poly(acrylic acid), poly(methacrylic acid), copolymers of maleic and acrylic acids, tannic acid, naphtholic and phenolic compounds, as well as urea and thiourea (44)(45)(46)(47)(48)(49). When equal amounts of solutions of poly(ethylene oxide) and poly(acrylic acid) are mixed, a precipitate, which appears to be an association product of the two polymers, forms immediately.…”

Section: Chemical Propertiesmentioning

confidence: 99%

Ethylene Oxide Polymers

Back

Schmitt

2004

Kirk-Othmer Encyclopedia of Chemical Technology

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Ethylene oxide polymers are high molecular weight (>100,000) water‐soluble thermoplastic polymers. This article reviews the effect of shear, pH, salt, and temperature on the physical and chemical properties of poly(ethylene oxide) solutions and melts. Industrial uses of the unique properties of poly(ethylene oxide) in fields such as flocculation, pharmaceutical excipients, adhesives, coatings, and personal care are summarized.

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“…Miscible blends of polymer and drug are of great interest as reduction in the drug domain size to molecular scale decreases the likelihood that the drug will recrystallize from the formulations and revert to its more stable crystalline form . A greater likelihood of producing stable homogenous amorphous systems results from strong H‐bonding, dipole–dipole interactions, hydrophobic, acid–base ionic interactions, or a combination of interactions between the components . We hypothesize that by identifying miscible combinations of somewhat hydrophobic polymers with somewhat hydrophilic polymers, the resulting pairwise blends may better address these complex, at times conflicting requirements for an effective ASD system.…”

Section: Introductionmentioning

confidence: 99%

“…13 A greater likelihood of producing stable homogenous amorphous systems results from strong H-bonding, dipole-dipole interactions, hydrophobic, acid-base ionic interactions, or a combination of interactions between the components. 20,29 We hypothesize that by identifying miscible combinations of somewhat hydrophobic polymers with somewhat hydrophilic polymers, the resulting pairwise blends may better address these complex, at times conflicting requirements for an effective ASD system. The hypothesis is supported by findings that demonstrate more effective crystal growth inhibition by hydrophobic/hydrophilic polymer combinations.…”

Section: Introductionmentioning

confidence: 99%

Pairwise Polymer Blends for Oral Drug Delivery

Marks

Wegiel

Taylor

et al. 2014

Journal of Pharmaceutical Sciences

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Blends of polymers with complementary properties hold promise for addressing the diverse, demanding polymer performance requirements in amorphous solid dispersions (ASDs), but we lack comprehensive property understanding for blends of important ASD polymers. Herein, we prepare pairwise blends of commercially available polymers polyvinylpyrrolidone (PVP), the cationic acrylate copolymer Eudragit 100 (E100), hydroxypropyl methylcellulose acetate succinate (HPMCAS), carboxymethyl cellulose acetate butyrate (CMCAB), hydroxypropyl methylcellulose (HPMC), and the new derivative cellulose acetate adipate propionate (CAAdP). This study identifies miscible binary blends that may find use, for example, in ASDs for solubility and bioavailability enhancement of poorly water-soluble drugs. Differential scanning calorimetry, FTIR spectroscopy, and film clarity were used to determine blend miscibility. Several polymer combinations including HPMCAS/PVP, HPMC/CMCAB, and PVP/HPMC appear to be miscible in all proportions. In contrast, blends of E100/PVP and E100/HPMC showed a miscibility gap. Combinations of water-soluble and hydrophobic polymers like these may permit effective balancing of ASD performance criteria such as release rate and polymer-drug interaction to prevent nucleation and crystal growth of poorly soluble drugs. Miscible polymer combinations described herein will enable further study of their drug delivery capabilities, and provide a potentially valuable set of ASD formulation tools.

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Polymer-polymer complexation in dilute aqueous solutions: poly(acrylic acid)-poly(ethylene oxide) and poly(acrylic acid)-poly(vinylpyrrolidone)

Cited by 74 publications

References 0 publications

Infrared spectra of γ‐irradiated poly(acrylic acid)–polyacrylamide complex

Infrared spectra of γ‐irradiated poly(acrylic acid)–polyacrylamide complex

Ethylene Oxide Polymers

Pairwise Polymer Blends for Oral Drug Delivery

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