Polymer nanotherapeutics: A promising approach toward microglial inhibition in neurodegenerative diseases
Sanaz Keshavarz Shahbaz,
Khadije Koushki,
Samaneh Keshavarz Hedayati
et al.
Abstract:Nanoparticles (NPs) that target multiple transport mechanisms facilitate targeted delivery of active therapeutic agents to the central nervous system (CNS) and improve therapeutic transport and efficacy across the blood‐brain barrier (BBB). CNS nanotherapeutics mostly target neurons and endothelial cells, however, microglial immune cells are the first line of defense against neuronal damage and brain infections. Through triggering release of inflammatory cytokines, chemokines and proteases, microglia can howev… Show more
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