Polymer nanoliter well arrays for liquid storage and rapid on-demand electrochemical release

Vastesson, Alexander; Guo, Maoxiang; Haraldsson, Tommy; Wijngaart, Wouter van der

doi:10.1016/j.snb.2018.04.013

Cited by 2 publications

(1 citation statement)

References 31 publications

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“…As of today, OSTE polymers are widely used in applied research. In addition to common microfluidic systems, OSTE polymers are used for various applications: nanoliter well arrays for liquid storage [ 16 ], optical tweezers [ 17 ], synthetic paper used in immunoassays [ 18 ], devices for plasma separation [ 19 ], the chips capable of sample desalting, concentration and separation [ 20 ], or enzymatic digestion prior to mass spectrometry [ 21 ], substrates for flexible electrodes [ 22 ], and gate dielectric for use in organic thin-film transistors (OTFTs) [ 23 ]. Composite materials have also been developed based on OSTE polymers.…”

Section: Introductionmentioning

confidence: 99%

Off-Stoichiometry Thiol–Enes Polymers Containing Silane Groups for Advanced Packaging Technologies

et al. 2022

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New modified off-stoichiometry thiol–enes polymers, called OSTE-MS polymers, were developed by introducing mercaptosilane into the polymer mixture. This modification made it possible to introduce silane groups into the polymer frame, due to which the polymer gained the ability to bond with silicon wafers without modification of the wafer surface by any adhesive. The optimal composition for creating 3D polymer structures on a chip was selected, which consists of a volume ratio of 6:6:1 of allyl monomer, mercapto monomer, and mercaptosilane, respectively. The hardness, shift force, tensile strength, Young’s modulus, optical transparency, glass transition temperature, thermal stability, and chemical resistance of the OSTE-MS polymer, and the viscosity for the prepolymer mixture were studied. On the basis of the OSTE-MS polymer, 3D polymer structures of the well type and microfluidic system on the silicon chips were obtained.

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Section: Introductionmentioning

confidence: 99%

Off-Stoichiometry Thiol–Enes Polymers Containing Silane Groups for Advanced Packaging Technologies

et al. 2022

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Nanoliter Liquid Packaging in a Bioresorbable Microsystem by Additive Manufacturing and its Application as a Controlled Drug Delivery Device

Park

Bertsch

Martin‐Olmos

et al. 2023

Adv Funct Materials

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Precise packaging of nanoliter amounts of liquid in a microsystem is important for many biomedical applications. However, existing liquid encapsulation technologies have limitations in terms of liquid waste, evaporation, trapped bubbles, and liquid degradation. In this study, multiple additive manufacturing techniques for nanoliter liquid packaging in bioresorbable microsystems is used. Two‐photon photolithography is used for bioresorbable reservoir fabrication, while inkjet printing (IJP) is used for precise nanoliter liquid packaging. Dual IJP allows for micro‐reservoirs to be filled with precise amounts of drug solution and subsequently and rapidly sealed with a layer of lipids mixed with Fe3O4 nanoparticles. Combining these two printing techniques can overcome the previous limitations of liquid encapsulation technologies. To demonstrate the relevance of this technique, a wirelessly activated, bioresorbable multi‐reservoir microcapsule that can be used for controlled drug delivery is presented. The microcapsules and their content are shown to be stable during fabrication, storage, and operation. Multiple cargo release events are triggered independently by the local melting of the sealing layer, resulting from magnetically induced Fe3O4 nanoparticle heating. The operation of the capsule is demonstrated in tissue phantoms and in vitro cell cultures.

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Polymer nanoliter well arrays for liquid storage and rapid on-demand electrochemical release

Cited by 2 publications

References 31 publications

Off-Stoichiometry Thiol–Enes Polymers Containing Silane Groups for Advanced Packaging Technologies

Off-Stoichiometry Thiol–Enes Polymers Containing Silane Groups for Advanced Packaging Technologies

Nanoliter Liquid Packaging in a Bioresorbable Microsystem by Additive Manufacturing and its Application as a Controlled Drug Delivery Device

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