Polymer Nanocomposites for Biomedical Applications

Lee²,

Surface & Interface Analysis

et al. 2008

There are several considerations when choosing a barrier membrane for use with guided tissue regeneration (GTR) to treat periodontal diseases: biocompatibility, cell-occlusiveness, space-maintaining ability, tissue integration, and clinical manageability can all affect success. Our laboratory developed drug-releasing and space-maintaining membranes for use with GTR to provide effective periodontal therapy. Tetracycline is used in periodontal therapy because of its antibacterial activity and because it enhances tissue regeneration by increasing osteoblast and anticollagenolytic activity. Here, tetracycline-containing solutions of the polymers poly(L-lactide), poly(L-lactide-co-glycolide), and poly(glycolide-co-caprolactone) were used to coat collagen sponges using a spray-coating technique. The surface structure and morphology of the prepared membranes were characterized and the drug release, antibacterial effect, and mechanical properties were evaluated. All membranes comprised double layers: a dense coated layer and a collagen layer. The collagen layer had a porous surface and interconnected pores. In contrast, the coated layer was a thin film without pores and had a low concentration of polymer. This biodegradable, polymercoated collagen membrane retained its drug release properties as well as antibacterial effect and had better mechanical integrity than uncoated collagen sponge. Taken together, these results suggest that tetracycline-loaded membranes might enhance GTR efficacy.

Section: Mechanical Characterizationsupporting

confidence: 77%

“…[4,5] Preventing infection during GTR is critical for success. Recently, several studies reported that some periodontal pathogens could colonize and adhere to the GTR membrane.…”

Section: Introductionmentioning

confidence: 99%

Surface modification of a guided tissue regeneration membrane using tetracycline‐containing biodegradable polymers

Lee²,

Surface & Interface Analysis

et al. 2008

Janaki Med. Coll. J. Med. Sci.

“…Many efforts have been made in the last decades using novel nanotechnology and nanoscience knowledge in order to obtain nanocomposities with determined biomedical use [1], [2]. The Metal-polymer nanocomposites are a typical example of using nano-particles (nanostructured metal) as additives in polymer matrix.…”

Section: Inroductionmentioning

confidence: 99%

Current view on biomedical applications of synthetic metal-polymer nanocomposites

Kaushik¹,

Sharma²

2014

Recent advances in the field of nanotechnology led several groups to recognize the promise of recruiting nanocomposities to the ongoing battle against pathogenic gram-positive and gramnegative bacteria and metal-polymer nanocomposites are a typical example. On the basis of recent literature, the nanocomposities are synthesized mainly by two techniques i.e. in-situ and ex-situ technique and these nanocomposities have great biomedical applications in terms of their antibacterial activity. A large battery of newly developed and discovered nanocomposities has been accumulating during the last decade.

Computer Methods in Biomechanics and Biomedical Engineering

“…The improved understanding of the hierarchical design laws might further enable the development and application of new organic and organic-inorganic multi-featured composites (such as assemblies of carbon nanotubes and proteins or polymer-protein composites [Cui et al 2007;Hule and Pochan 2007;Winey and Vaia 2007)], which will mainly consist of chemical elements that appear in our environment in an almost unlimited amount (C, H, N, O and S). These materials might consequently help to solve human's energy and resource problems (e.g.…”

Section: Q1mentioning

confidence: 99%

Nanomechanical strength mechanisms of hierarchical biological materials and tissues

Buehler

Ackbarow

2008

Biological protein materials (BPMs), intriguing hierarchical structures formed by assembly of chemical building blocks, are crucial for critical functions of life. The structural details of BPMs are fascinating: They represent a combination of universally found motifs such as a-helices or b-sheets with highly adapted protein structures such as cytoskeletal networks or spider silk nanocomposites. BPMs combine properties like strength and robustness, self-healing ability, adaptability, changeability, evolvability and others into multi-functional materials at a level unmatched in synthetic materials. The ability to achieve these properties depends critically on the particular traits of these materials, first and foremost their hierarchical architecture and seamless integration of material and structure, from nano to macro. Here, we provide a brief review of this field and outline new research directions, along with a review of recent research results in the development of structureproperty relationships of biological protein materials exemplified in a study of vimentin intermediate filaments.